ABSTRACT
In general, the origins of the double transverse red cross (Croix à double traverse), such as that of Lorraine, is less evident than that of the "Double Red Cross" ("Double Croix-Rouge"), as exemplified by the international emblem of the battle against tuberculosis. The importance of the proportions of the latter is emphasised.
Subject(s)
Emblems and Insignia/history , Emergency Medical Services/history , Rescue Work/history , Symbolism , Tuberculosis/history , History, Early Modern 1451-1600 , History, Medieval , History, Modern 1601- , Humans , Red Cross/historyABSTRACT
The use of multivariate confidence regions is proposed for the classification of clinical laboratory profiles into diagnostic classes. For this purpose, a multivariate confidence region is developed for each diagnostic class. Three methods (UNEQ, EQ, and SIMCA) are evaluated and compared with classical linear discriminant analysis. As an example, a small data set concerning the differentiation of the thyroid functional states on the basis of five laboratory tests is used. It is shown that related procedures can produce results of very different quality and that the multivariate region approach is attractive for the clinician's daily practice since the methods are easily implemented on a microcomputer.
Subject(s)
Computers , Diagnosis, Computer-Assisted , Microcomputers , Humans , Hyperthyroidism/diagnosis , Hypothyroidism/diagnosis , Statistics as Topic , Thyroid Function TestsABSTRACT
The intrathyroidal stable iodine (ITI) determined in 776 patients chosen at random. Ninety % of these patients presented with nontoxic goiter. Curve-filtering analysis techniques showed a seasonal variation in ITI: an acrophase was found in April/May, a nadir in September/October. The possible relationship of this seasonal variation with the intake of iodine or alimentary antithyroid substances are discussed, as well as possible relationship with variation in chronic TSH stimulation related to ambient temperature.
Subject(s)
Goiter/metabolism , Iodine/analysis , Seasons , Thyroid Gland/analysis , Fluorescence , Humans , X-RaysABSTRACT
Cardiac patients treated with the iodine-containing drug 'amiodarone' undergo a significant iodine overload which can last for months after the drug has been withdrawn. Some patients develop hyperthyroidism and others hypothyroidism. In the hyper- or hypothyroid patients, the indices of thyroid function are modified as usually observed in these situations. In the patients remaining euthyroid while taking amiodarone or after its withdrawal, but still under its influence as shown by the iodine overload, a 'low-T3 syndrome' is observed, this state being characterized by a high total T4, a low free T4, a normal T3 resin uptake, a low total T3, a normal free T3, a high r-T3 and a relative TSH-unresponsiveness to TRH.
Subject(s)
Amiodarone/adverse effects , Benzofurans/adverse effects , Triiodothyronine/deficiency , Humans , Iodine/adverse effects , Iodine/metabolism , Thyroid Diseases/chemically induced , Thyroxine/metabolismABSTRACT
Amiodarone is a drug which is frequently used in cardiology, and which can lead to the appearance of hyper- of hypo-thyroidism in certain cases. A study of the various parameters of thyroid function has shown that these are abnormal in every case treated by this drug, without the biochemical abnormalities necessarily being reflected clinically. The authors outline a method which will allow a distinction to be drawn between patients with a true thyroid malfunction and those whose biochemical results do not appear at first sight to be of any consequence. Regular assays of the T3RIA level are suggested as a means of early detection of thyroid malfunction in patients undergoing treatment with amiodarone.
