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1.
Rehabilitación (Madr., Ed. impr.) ; 56(4): 279-283, Oct-Dic. 2022. tab
Article in Spanish | IBECS | ID: ibc-210839

ABSTRACT

Introducción y objetivos: El déficit de marcha y las caídas en pacientes con esclerosis lateral amiotrófica (ELA) restringen la movilidad. El objetivo de este estudio es examinar el uso apropiado de dispositivos de ayuda para la marcha y silla de ruedas para deambular basados en el riesgo de caídas y la velocidad de marcha de pacientes con ELA. Métodos: Se incluyeron datos retrospectivos de pacientes de la clínica ELA. Se registraron edad, género, tiempo de evolución, uso de silla de ruedas, dispositivo de ayuda para la marcha, velocidad de marcha y escala de Berg. Se relacionaron las variables categóricas con la prueba de chi cuadrado y test exacto de Fisher. Resultados: Cincuenta y ocho pacientes cumplieron con los criterios de inclusión. Veintisiete (46,55%) tuvieron uso adecuado de silla de ruedas basado en la velocidad de marcha (p=0,50). Esta asociación disminuye al 6% en pacientes que caminaron a velocidad menor a 0,88m/s. Cuarenta y dos (70,69%) tuvieron uso adecuado de dispositivo de ayuda para la marcha basado en el riesgo de caídas (P=0,001). Del subgrupo con puntaje de Berg ≤ 45, el 38% no empleó el dispositivo apropiado (p=0,06). Conclusiones: Los pacientes con severo déficit de equilibrio y de marcha tuvieron un uso inapropiado de dispositivos para caminar y/o silla de ruedas. Los hallazgos del presente estudio pueden significar un aporte que podría ser considerado en las evaluaciones clínicas de pacientes con ELA para minimizar los riesgos y mejorar la participación de este colectivo de personas.


Introduction and objectives: Gait deficits and falls in patients with amyotrophic lateral sclerosis (ALS) restrict mobility. The aim of this study is to examine the appropriate use of walking aids and wheelchairs, based on the risk of falling and walking speed of patients with ALS. Methods: Retrospective data from patients from the ALS clinic were included. Age, gender, evolution time, wheelchair use, walking aids, gait speed and the Berg Balance Scale were registered. Categorical variables were related to the Chi Square test and Fisher's exact test. Results: Fifty eight patients met the inclusion criteria. Twenty-seven (46.55%) had adequate use of a wheelchair based on walking speed (p=.50). This association decreases to 6% in patients who walked at a speed lower than 0.88m/s. Forty-two (70.69%) had adequate use of an assistive device based on the risk of falls (p=.001). Of the subgroup with Berg Balance score ≤ 45, 38% did not use the appropriate device (p=.06). Conclusion: Patients with severe gait and balance deficits had inappropriate use of walking aids and/or wheelchairs. The findings of this study may mean a contribution that could be considered in the clinical evaluations of patients with ALS to minimize risks and improve the participation of this group of people.(AU)


Subject(s)
Humans , Male , Female , Amyotrophic Lateral Sclerosis , Physical Functional Performance , Patients , Wheelchairs , Walking Speed , Accidental Falls , Rehabilitation , Retrospective Studies , Argentina , Data Interpretation, Statistical
2.
Rehabilitacion (Madr) ; 56(4): 279-283, 2022.
Article in Spanish | MEDLINE | ID: mdl-35637028

ABSTRACT

INTRODUCTION AND OBJECTIVES: Gait deficits and falls in patients with amyotrophic lateral sclerosis (ALS) restrict mobility. The aim of this study is to examine the appropriate use of walking aids and wheelchairs, based on the risk of falling and walking speed of patients with ALS. METHODS: Retrospective data from patients from the ALS clinic were included. Age, gender, evolution time, wheelchair use, walking aids, gait speed and the Berg Balance Scale were registered. Categorical variables were related to the Chi Square test and Fisher's exact test. RESULTS: Fifty eight patients met the inclusion criteria. Twenty-seven (46.55%) had adequate use of a wheelchair based on walking speed (p=.50). This association decreases to 6% in patients who walked at a speed lower than 0.88m/s. Forty-two (70.69%) had adequate use of an assistive device based on the risk of falls (p=.001). Of the subgroup with Berg Balance score ≤ 45, 38% did not use the appropriate device (p=.06). CONCLUSION: Patients with severe gait and balance deficits had inappropriate use of walking aids and/or wheelchairs. The findings of this study may mean a contribution that could be considered in the clinical evaluations of patients with ALS to minimize risks and improve the participation of this group of people.


Subject(s)
Amyotrophic Lateral Sclerosis , Wheelchairs , Amyotrophic Lateral Sclerosis/complications , Humans , Physical Functional Performance , Postural Balance , Retrospective Studies , Walking
3.
Support Care Cancer ; 25(7): 2137-2145, 2017 07.
Article in English | MEDLINE | ID: mdl-28204993

ABSTRACT

PURPOSE: The aims of this study are to identify neuro-oncological patients' and their caregivers' needs during hospitalization (T0) and at 4 months after discharge (T1); to analyze the longitudinal changes in patients' and caregivers' needs and burden; to identify correlations between patients' needs and caregivers' burden and needs. METHODS: A pilot observational longitudinal study was conducted on 94 neuro-oncological patients and their caregivers using NEQ to evaluate patients' needs, CNA, and FSQ for caregivers' needs and burden at T0 and T1. Descriptive statistics were performed to illustrate the distribution of questionnaires' scores. The longitudinal change of NEQ, FSQ, and CNA scores were investigated using Wilcoxon test. Spearman's correlation was used to measure the relation between NEQ and FSQ and CNA scores. RESULTS: The most frequent patients and caregivers' needs were material and informative. Needs tend to decrease over time; in particular FSQ factor "need for knowledge about the disease", CNA factor "Information/communication needs" and CNA total score significantly decreased (p < 0.001). NEQ total score significantly correlated with FSQ factors "emotional burden" and "need for knowledge about the disease" and CNA total and factors scores at T0 and T1. At T0, NEQ correlated significantly with FSQ factor "thoughts about death", while at T1, it correlated with FSQ factor "problems in social involvement". CONCLUSIONS: It is crucial to plan an assessment of patients' and caregivers' needs from the very beginning, in order to identify those individuals potentially at risk of developing high level of distress and to provide information and support following the illness trajectory of the brain tumor.


Subject(s)
Adaptation, Psychological/physiology , Caregivers/psychology , Adult , Aged , Aged, 80 and over , Communication , Female , Hospitalization , Humans , Longitudinal Studies , Male , Middle Aged , Patient Discharge , Pilot Projects , Surveys and Questionnaires , Young Adult
4.
Clin Neurol Neurosurg ; 146: 123-9, 2016 Jul.
Article in English | MEDLINE | ID: mdl-27208872

ABSTRACT

OBJECTIVE: The objective of this study is to assess the feasibility of simultaneous Sodium Fluorescein (SF) and Indocyanine Green (ICG) injection during neurosurgical procedures. PATIENTS AND METHODS: Three patients harboring a high-grade glioma (HGG) were retrospectively identified in the surgical database of the Neurosurgical Unit 2 at the Foundation IRCCS Istituto Neurologico C. Besta in Milan, by having received intraoperatively both SF for tumor resection and ICG for vasculature angiographic studies in the same surgical procedure. We identified 2 males and 1 female (age range 25-60). Lesions were located in the left temporo-polar area and hippocampus (1 case), right superior frontal gyrus (1 case), left supplementary motor area (1 case). All the three lesions showed Magnetic Resonance Imaging (MRI) characteristics of HGG and, for this reason, in all patients a fluorescein-guided tumor removal was proposed. In the same surgical procedure ICG videoangiography was considered necessary in order to study arterial and venous vasculature, given by the strict relation of the tumor with an unexpected Posterior Communicating Artery (PComA) aneurysm in one case and with cortical drainage veins complexes in the other two cases. In all cases a microscope equipped with both YELLOW560 and IR800 integrated filters (Pentero 900, Carl Zeiss, Oberkorchen, Germany) was used. Fluorescein was i.v. injected at a dose of 5mg/kg immediately after patient intubation. ICG was i.v. injected in bolus on demand of the operating surgeon at a dose of 12.5mg. RESULTS: No side-effects related to simultaneous injection of SF and ICG were identified. In all three cases, the use of SF allowed to better visualize the tumor areas during surgical removal, thus leading to a radical resection until no macroscopic appearance of residual tumor mass and no fluorescence was visible in the surgical cavity. ICG videoangiography confirmed the patency of branches of internal carotid artery after clipping of an unexpected small PComA aneurysm found intraoperatively during tumor removal in one case, while in patient 2 and 3 it allowed to evaluate patency and study flow pattern in cortical drainage veins that were intimately related to the tumors and the way of the surgical approach. Postoperative MRI showed a Gross Total Resection of the tumors in all cases. CONCLUSIONS: This study showed for the first time the feasibility of intravenous SF injection and ICG videoangiography in the same surgical procedure. The presence of different fluorescence filters on the same surgical microscope allows the surgeon to recognize and safely resect the tumor and simultaneously evaluate local brain vascularization.


Subject(s)
Coloring Agents/administration & dosage , Fluorescein/administration & dosage , Indocyanine Green/administration & dosage , Neurosurgical Procedures/methods , Adult , Coloring Agents/adverse effects , Feasibility Studies , Female , Fluorescein/adverse effects , Humans , Indocyanine Green/adverse effects , Male , Middle Aged , Young Adult
5.
Acta Neurochir Suppl ; 109: 251-7, 2011.
Article in English | MEDLINE | ID: mdl-20960352

ABSTRACT

PURPOSE: To investigate the application of indocyanine green (ICG) videoangiography during microsurgery for central nervous system (CNS) tumors. METHODS: One hundred patients with CNS tumors who underwent microsurgical resection from December 2006 to December 2008 were retrospectively analyzed. The diagnosis was high grade glioma in 54 cases, low grade in 17 cases, meningioma in 14 cases, metastasis in 12 cases and hemangioblastoma in 3 cases. Overall, ICG was injected intraoperatively 194 times. The standard dose of 25mg of dye was injected intravenously and intravascular fluorescence from within the blood vessels was imaged through an ad hoc microscope with dedicated software (Pentero, Carl Zeiss Co., Oberkochen, Germany). Pre-resection and post-resection arterial, capillary and venous ICG videoangiographic phases were intraoperatively observed and recorded. RESULTS: ICG videangiography allowed for a good evaluation of blood flow in the tumoral and peritumoral exposed vessels in all cases. No side effects due to ICG were observed. CONCLUSIONS: ICG video-angiography is a significant method for monitoring blood flow in the exposed vessels during microsurgical removal of CNS tumors. Pre-resection videoangiography provides useful information on the tumoral circulation and the pathology-induced alteration in surrounding brain circulation. Post-resection examination allows for an immediate check of patency of those vessels that are closely related to the tumor mass and that the surgeon does not want to damage.


Subject(s)
Central Nervous System Neoplasms/diagnostic imaging , Central Nervous System Neoplasms/surgery , Coloring Agents , Fluorescein Angiography/methods , Indocyanine Green , Monitoring, Intraoperative/methods , Humans , Radiography , Retrospective Studies , Videodisc Recording/methods
6.
Article in Spanish | IBECS | ID: ibc-81844

ABSTRACT

La conquista de la dignidad es lo que merece toda persona humana por el mero hecho de serlo, con todas y cada una de las particularidades y de las diferencias y esto es aplicable también a las personas con discapacidad. Además, el respeto dignifi ca a quien lo siente y lo practica. La bioética pone a nuestro alcance un análisis crítico y razonado sobre nuestro comportamiento, para conocer los valores en los que basamos nuestras actuaciones. La ética que la sustenta no es ningún moralismo, sino una refl exión racional sobre lo que hacemos y por qué lo hacemos. Se trata, de ir adquiriendo una mayor conciencia para poder progresar y ayudar a hacerlo. Progreso y salud son conceptos muy vinculados a la idea de emancipación personal. Para considerar esta autoconstrucción es preciso saber verla como un esfuerzo, siempre admirable, para aprovechar la oportunidad de vivir. Este esfuerzo merece disfrutar de los derechos a la protección general: a la no discriminación, la privacidad y la confi dencialidad, la expresión de autonomía con la forma y la limitación que se tenga. La solidaridad y la ayuda personalizada es un acompañamiento sensible a las necesidades personales y cambiantes. Acompañar no es caminar en el lugar del otro, sino saber estar y caminar a su lado, “estar a su lado”. Si nos tomamos en serio los derechos humanos, de todos las personas, sea cual sea su característica, veremos que las preguntas que nos tenemos que plantear tienen que ser numerosas, cotidianas y valientes (AU)


The conquering of dignity is the consideration which all human beings deserve simply for what we are in each and every one of the particularities and differences which defi ne us; applicable to persons with disabilities as much as the rest. In addition, respect dignifi es those who feel and show it. Bioethics would like to put within our reach a habit of critical thinking and reasoned analysis of our behaviour, to identify the values on which we base our actions. The ethics sustaining it by no means correspond to moralism, rather a rational consideration of what and why we do something. It is a question of acquiring greater awareness in order to be able to progress and help with this. Progress and health as concepts are closely linked to the idea of personal emancipation. To consider this self-construction, it is a question of seeing it as an effort, always admirable, to take advantage of the opportunity to live. This effort deserves to enjoy entitlement to general protection, i.e., lack of-discrimination, privacy and confi dentiality: an expression of autonomy taking the form it takes and having limitations. The help which everyone needs must be a companion sensitive to personal and changing needs. Accompanying does not mean walking in somebody else’s place, nor overtaking them, but knowing how to be with someone and walk “by their side”. If we take seriously human rights of all humans whatever their characteristics, then we will see that the questions we should ask ourselves are numerous, daily and requiring courage (AU)


Subject(s)
Humans , Male , Female , Child , Bioethics/education , Bioethics/trends , Bioethical Issues/standards , Human Rights/education , Human Rights/psychology , Human Rights/statistics & numerical data , Human Rights/standards , Human Rights/trends , Disability Evaluation , Ethics
7.
J Neurosurg Sci ; 54(2): 55-63, 2010 Jun.
Article in English | MEDLINE | ID: mdl-21313956

ABSTRACT

AIM: The aim of this study was to evaluate the feasibility of microscopic endoscopic assisted suprameatal tubercle drilling with a retrosigmoid approach and it focuses on the anatomic structures identified with the endoscope. The advantages of the 30 degrees optic view are also described. METHODS: Fifty dry temporal bones were studied in order to estimate the variability of the prominence of the suprameatal tubercle. Eight fresh cadaveric specimens were prepared for a retrosigmoid approach to allow for microscopic endoscopic assisted suprameatal tubercle drilling. The increase in trigeminal exposure and neurovascular structures visualization with the endoscope, using 0 degrees and 30 degrees optics were then evaluated. RESULTS: Three major types of the suprameatal tubercle were found: 1) a large size tubercle (> 6 mm, 9/50 cases); 2) a medium size tubercle (3-6 mm, 37/50 cases); and 3) an almost absent suprameatal tubercle (< 3 mm, 4/50 cases). Microscopic endoscopic assisted suprameatal tubercle drilling with opening of the Meckel's Cave was found to be technically feasible in all cases. The increase in trigeminal nerve exposition was of 9 mm on average. Endoscopic exploration with 0 degrees and 30 degrees optics made possible the identification of all neurovascular structures in the area. CONCLUSION: Microscopic endoscopic assisted suprameatal tubercle drilling is a feasible procedure that allows the identification of all neurovascular structures in the cerebellopontine angle and petrous apex region. The opening of Meckel's Cave may be particularly useful for lesions located in the cerebellopontine angle having a minor component that extends anteriorly and laterally in the middle cranial fossa.


Subject(s)
Endoscopy/methods , Microsurgery/methods , Neurosurgical Procedures/methods , Petrous Bone/anatomy & histology , Petrous Bone/surgery , Cadaver , Cerebellopontine Angle/anatomy & histology , Cerebellopontine Angle/surgery , Cranial Fossa, Middle/anatomy & histology , Cranial Fossa, Middle/surgery , Humans
8.
Transplant Proc ; 37(6): 2651-3, 2005.
Article in English | MEDLINE | ID: mdl-16182775

ABSTRACT

We examined surgical complications among a group of diabetic type 1 patients (IDDM) with end-stage renal disease (ESRD) who had undergone pancreas-kidney transplantations (PK). Between October 1993 and August 2004, 70 SPK were performed using bladder (n = 14) or enteric (n = 56) drainage. Donors were selected according to standard criteria (mean age, 27.6 years; range, 17-49). All patients received cyclosporine-based immunosuppression. All pancreata functioned immediately, whereas 2 patients needed postoperative dialysis. Four patients (5.7%) lost their pancreatic graft due to vascular thrombosis; both patients underwent urgent allograft pancreaectomy and pancreas retransplantation (re-PT). One of them (1.4%) experienced a venous thrombosis and died due to a pulmonary embolism at 12 hours after re-PT. The other 3 patients had uneventful postoperative courses and were discharged with good pancreatic and renal function. Three patients in the bladder group (21.4%) had an anastomotic leak, which resolved with a bladder catheter. Four patients in the enteric group (7.1%) who experienced an anastomotic leak needed a second surgical procedure but in 3 of them allograft pancreatectomy was necessary. Relaparotomy was required in the other 3 patients due to hemorrhage (1 patient) or occlusion (2 patients). Acute rejection episodes, which occurred in 16 patients (22.8%), were treated with steroid boluses. With a mean follow-up of 72 months (range, 3-129), 2 patients have died at 8 and at 36 months, respectively, after SPK due to acute myocardial infarction (2.9%). Chronic rejection was the leading cause of pancreatic failure in 5 patients (7.1%) and of renal failure in 2 patients (2.8%). Patient, kidney, and pancreas survival rates were 95.8%, 92.9%, and 81.5%, respectively. Surgical complications were the leading cause of pancreatic allograft loss in IDDM and ESRD patients submitted to SPK.


Subject(s)
Diabetes Mellitus, Type 1/surgery , Diabetic Nephropathies/surgery , Intraoperative Complications/epidemiology , Kidney Failure, Chronic/surgery , Kidney Transplantation , Pancreas Transplantation/physiology , Adult , Drainage/methods , Female , Graft Survival , Humans , Kidney Transplantation/adverse effects , Kidney Transplantation/mortality , Kidney Transplantation/physiology , Male , Middle Aged , Pancreas Transplantation/adverse effects , Pancreas Transplantation/mortality , Patient Selection , Retrospective Studies , Survival Analysis , Tissue Donors , Treatment Failure , Urinary Bladder/surgery
9.
J Invest Surg ; 18(1): 13-8, 2005.
Article in English | MEDLINE | ID: mdl-15804947

ABSTRACT

Pancreatic islet transplantation has been proposed as an attractive option for the treatment of type I diabetes. Transplantation into different sites has been investigated, among them those that are immuno-logically privileged (e.g., thymus, uterus, brain, anterior eye chamber, and testicle). Because of their characteristics, seminal vesicles could be considered as immunologically privileged organs, but there is no worldwide experience that can confirm it. The purpose of the present study is to assess the viability and functionality of islet transplantation into seminal vesicles of diabetic rats. One hundred ninety inbred adult male syngeneic Lewis rats were used as donors (n = 72), receptors (n = 36), and controls(n = 11). Diabetes was chemically induced through a single intraperitoneal injection of streptozotocin. Groups of 1200 purified islets were introduced in the right seminal vesicle of diabetic rats. Diabetic control rats were sham transplanted. Body weight and glycemia were monitored every 2 d. Of transplanted rats, 16.7% achieved a good function due to islet engraftment, while 30.6% achieved a partially good response, and 52.7% were considered as nonresponding. This is the first report about islet transplantation into seminal vesicles of diabetic animals. Our results indicate that islet transplantation into rat seminal vesicles is technically possible, and that islets can function normally after engraftment into the wall of the seminal vesicle.


Subject(s)
Diabetes Mellitus, Experimental/surgery , Graft Survival , Islets of Langerhans Transplantation/methods , Seminal Vesicles/surgery , Animals , Blood Glucose , Body Weight , Diabetes Mellitus, Experimental/blood , Hyperglycemia/blood , Hyperglycemia/surgery , Male , Rats , Rats, Inbred Lew
12.
Ann Oncol ; 11(6): 701-5, 2000 Jun.
Article in English | MEDLINE | ID: mdl-10942059

ABSTRACT

BACKGROUND: Sentinel node biopsy (SNB) has been proposed as an alternative to axillary lymph-node dissection (ALND) in breast cancer. Before implementing SNB in our practice, we wished to test its validity by comparing it to the standard ALND, both in our hands and with other reported series. PATIENTS AND METHODS: One hundred thirty-two patients were included prospectively. SNB and immediate ALND were performed. For SNB, a technetium-colloid was used to produce preoperative lymphoscintigraphy and intraoperative gamma-probe search for the SN. Serial sectioning and immunostains were used on the SN. A comprehensive review of the literature was done in order to run a meta-analysis of diagnostic tests using a summary receiver operating characteristic curve (SROC) to calculate the pooled parameters of sensitivity and associated 95% confidence interval (95% CI), including our own data. RESULTS: Our technical success rate was 96%. Local sensitivity was 96%, with a 95% CI from 85%-99%. Seven patients were upstaged by the SNB. A literature search identified 18 studies published from 1996-1999. Estimates of sensitivity ranged from 83%-100%. The pooled data meta-analysis gave a global sensitivity of 91%, with a 95% CI from 89%-93%. The area under the global SROC curve was 0.9967. CONCLUSIONS: The minimally invasive SNB was shown to be a practical alternative to ALND. We propose to use local as well as global sensitivity and associated 95% CI to test the validity of SNB in the clinical setting. Due to limitations of ALND as the golden standard, SNB can in fact be considered a more accurate method for nodal staging.


Subject(s)
Breast Neoplasms/pathology , Lymph Node Excision , Sentinel Lymph Node Biopsy , Adult , Aged , Aged, 80 and over , Axilla , Female , Humans , Middle Aged , Prospective Studies , ROC Curve , Sensitivity and Specificity , Technetium
13.
Breast ; 9(1): 58-9, 2000 Feb.
Article in English | MEDLINE | ID: mdl-14731587
14.
Thromb Haemost ; 79(5): 916-8, 1998 May.
Article in English | MEDLINE | ID: mdl-9609220

ABSTRACT

In a previous report we found an inverse correlation between pre-operative platelet count (PlC) levels and the risk of post-operative pulmonary embolism in patients undergoing hip surgery. In the present study, we prospectively evaluated the prognostic significance of pre-operative PlC levels on survival in 180 consecutive patients undergoing surgery for colorectal cancer. Other major clinicopathological parameters studied were age, gender, Dukes' stage, duration of surgery, pre-operative haemoglobin levels and transfusion requirements. There were no significant differences in mean pre-operative PlC levels according to tumor stage. Thirty-three patients (18%) died during follow-up (3-23 months, median: 13 months). Univariate analysis (Kaplan-Meier estimates) showed that advanced tumor stage (p < 0.001), duration of surgery (p < 0.05) and a high pre-operative PlC level (p < 0.001) were significantly associated to a poor survival. The multivariate Cox analysis revealed that tumor stage (RR:5.734; 95%C.I.: 2.644-12.44), a high pre-operative PlC level (RR: 2.467; 95%C.I.: 1.117-5.452), and to a lesser extent the patients' age remained independent prognostic variables for mortality. The findings of this preliminary study may be of interest from the point of view of pathogenesis, but also clinically, since they might be used in the decision as to which patients or groups of patients should receive more aggressive therapeutic intervention.


Subject(s)
Colorectal Neoplasms/blood , Hemorrhage/blood , Platelet Count , Postoperative Complications , Pulmonary Embolism/blood , Aged , Colorectal Neoplasms/mortality , Colorectal Neoplasms/surgery , Female , Hemorrhage/etiology , Humans , Male , Middle Aged , Predictive Value of Tests , Prognosis , Pulmonary Embolism/etiology
16.
J Nephrol ; 11(2): 87-93, 1998.
Article in English | MEDLINE | ID: mdl-9589380

ABSTRACT

Highly concentrated marine polyunsaturated fatty acids (n-3 PUFA), affecting the lipids and lipophilic drugs metabolism, can interfere with cyclosporine (CyA) pharmacokinetics. This prospective, randomized and placebo-controlled, double-blind study involved 42 kidney graft recipients. From day +1, 21 pts (E) received 6 g n-3 PUFA (85% EPA + DHA, Esapent, Pharmacia) and 21 pts (P) received placebo (olive oil), both reduced to 3 g from day +30 on. A quadruple immunosuppressive regimen was employed. Plasma creatinine, lipids and CyA pharmacokinetics were investigated 1, 3, 6, 9 and 12 months after graft. The two groups were comparable for age, weight, M/F ratio, hypertension prevalence and baseline lipids. Active treatment did not affect total and HDL-cholesterol, but significantly lowered triglycerides (E:120 +/- 12 vs P:166 +/- 21 mg/dl, p < 0.0001). At one year, E pts had lower creatinine than P (1.26 +/- 0.06 vs. 1.88 +/- 0.2 mg/dl, p < 0.05), comparable CyA dosage, and a larger CyA area under the curve (AUC) (n.s.), with a higher blood peak level (Cmax) (p < 0.04) and less variance in time to peak (n.s.). The larger AUC in the E group at all intervals and the better pattern of plasma creatinine, with no rise in blood pressure, provided evidence of better CyA absorption and metabolism in n-3 PUFA supplemented kidney graft recipients.


Subject(s)
Cyclosporine/pharmacokinetics , Fatty Acids, Omega-3/administration & dosage , Immunosuppressive Agents/pharmacokinetics , Kidney Transplantation/physiology , Adult , Area Under Curve , Creatinine/blood , Cyclosporine/administration & dosage , Double-Blind Method , Drug Interactions , Female , Follow-Up Studies , Graft Survival/drug effects , Humans , Immunosuppressive Agents/administration & dosage , Male , Middle Aged , Prospective Studies , Treatment Outcome , Triglycerides/blood
17.
Arch Surg ; 133(2): 189-93, 1998 Feb.
Article in English | MEDLINE | ID: mdl-9484733

ABSTRACT

OBJECTIVES: To study the incidence of band erosion in patients who have undergone vertical banded gastroplasty and to describe the reparative techniques used. DESIGN: A retrospective review case series. SETTING: A university hospital-based tertiary referral center. PATIENTS: Two hundred fifty consecutive morbidly obese patients who underwent vertical banded gastroplasty between 1987 and 1995. MAIN OUTCOME MEASURES: The development of band erosion into the stomach, reparative surgical techniques, and long-term weight loss control. RESULTS: Band erosion developed in 7 (2.8%) of the patients. Two patients had symptoms 1 month after undergoing forced endoscopy. Six patients required reoperation. The operative findings included 2 cases of "external" band erosion through the lesser curvature into the stomach and 4 cases of "internal" band erosion through the circular staple line. The surgical techniques used for repair depended on the radiological and endoscopic data and on the operative findings; the techniques included conversion into a gastric bypass, band replacement after the creation of a new stoma, and gastroplasty plus distal gastric bypass. There were no complications, and adequate long-term weight loss was achieved in all but 1 of the patients who underwent reoperation. CONCLUSION: Band erosion may be corrected using appropriate surgical techniques to allow for adequate long-term weight loss in patients who have undergone vertical banded gastroplasty.


Subject(s)
Gastroplasty/methods , Adult , Female , Humans , Incidence , Male , Middle Aged , Obesity, Morbid/surgery , Reoperation , Retrospective Studies , Treatment Outcome
18.
Eur J Pediatr Surg ; 6 Suppl 1: 21-4, 1996 Dec.
Article in English | MEDLINE | ID: mdl-9008814

ABSTRACT

In adults the development of modern equipment for ambulatory monitoring permits long-term evaluation of the lower urinary tract which is more accurate than standard urodynamics (SUD). In children continuous urodynamic monitoring (CUM) has been used infrequently and therefore standardisation of the method has not been previously achieved, nor have the techniques and difficulties of performing 24-hour monitoring been solved. The aim of this study was to identify a technical method of CUM in children which was feasible and to verify its usefulness. For this purpose, we reviewed our preliminary experiences of CUM in children with neuropathic bladder. From March to November 1995 we made an outpatient study of the neuropathic bladders of 11 myelodysplastic children aged 1 to 18 years (average age 10.2 years). 7 of them were males and 4 females. All underwent SUD. With the children resting in bed, a 6-hour CUM (Lectromed MPR-2) was performed using a 4 Fr. microtip intravesical catheter (suprapubic in 3 infants and transurethral in 8 children) and an intrarectal catheter. The parents and/or a nurse monitored the fluid intake and micturition events and recorded the data in a diary. Based on the CUM experience in infants with non-neurogenic bladder dysfunction, the 3 suprapubic studies were done after 12 hours of urethral drainage in order to prevent leakage of urine. In all of the patients we were able to study 2 to 4 bladder fillings during a period of 6 to 8 hours (average 6.5 hours) observation. In 9 of the 11 children the CUM pattern was comparable to the SUD one but in the 2 remaining patients CUM showed uninhibited contractions. Higher uninhibited voiding contraction pressures were recorded in hyper-reflexic bladders. Our preliminary results show that it is feasible to perform CUM in children and that it has advantages over standard cystometry in the investigation of children with neuropathic bladder even if it is carried out for short term (6 hours).


Subject(s)
Monitoring, Physiologic/instrumentation , Myelodysplastic Syndromes/physiopathology , Urinary Bladder, Neurogenic/physiopathology , Urodynamics/physiology , Adolescent , Adult , Ambulatory Care , Child , Child, Preschool , Equipment Design , Feasibility Studies , Female , Humans , Infant , Male , Myelodysplastic Syndromes/diagnosis , Reference Values , Signal Processing, Computer-Assisted/instrumentation , Urinary Bladder, Neurogenic/diagnosis , Urinary Catheterization/instrumentation , Vesico-Ureteral Reflux/physiopathology
20.
Nutr Hosp ; 10(6): 307-20, 1995.
Article in Spanish | MEDLINE | ID: mdl-8599615

ABSTRACT

UNLABELLED: Obesity as a condition, and morbid obesity as a disease, have at present reached epidemic proportions. Bariatric surgery is the most effective treatment in those patients in whom medical, dietary, and/or behavioral treatments have failed. What is more, it is the initial treatment of choice in morbid superobese patients (> 50 kg/m2). The present study summarizes and criticizes the main surgical techniques used at present, and purposes an action protocol for anesthesia, as well as some norms and advice on control, action, and pulmonary and dietary rehabilitation, in the peri- and post operative period, based on more than 7 years' experience with a series of more than 150 operated and controlled patients. CONCLUSION: A restrictive bariatric technique is a model which allows the multidisciplinary obesity treatment team to achieve a definite and permanent modification of the eating habits of all patients who meet the criteria for inclusion in a surgical protocol.


Subject(s)
Intraoperative Care , Obesity, Morbid/surgery , Anesthesia/methods , Body Mass Index , Clinical Protocols , Diet, Reducing , Female , Humans , Intraoperative Care/methods , Male , Obesity, Morbid/diagnosis , Postoperative Care/methods
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