ABSTRACT
A regression of tumor growth is observed when alkoxyglycerols are administered prior to radiation treatment of patients suffering from cancer of the uterine cervix. This regression is remarkably higher for patients below the age of 60 years than for those over 60. The regression has been demonstrated by a change in the quotient between the incidence of early and advanced stages.
Subject(s)
Glycerol/analogs & derivatives , Uterine Cervical Neoplasms/drug therapy , Adult , Age Factors , Clinical Trials as Topic , Combined Modality Therapy , Female , Glycerol/therapeutic use , Humans , Middle Aged , Uterine Cervical Neoplasms/mortality , Uterine Cervical Neoplasms/pathologyABSTRACT
The incidence of injuries following radiation therapy for carcinoma of the uterine cervix is markedly decreased by the administration of alkoxyglycerols. This is the case for less harmful injuries as well as for the more severe ones, i.e. the fistulas. Recto-vaginal and vesico-vaginal fistulas are reduced with 47 per cent when alkoxyglycerols are administered prior to radiation treatment.
Subject(s)
Glycerol/analogs & derivatives , Radiation Injuries/prevention & control , Radiotherapy/adverse effects , Rectovaginal Fistula/prevention & control , Uterine Cervical Neoplasms/radiotherapy , Vesicovaginal Fistula/prevention & control , Female , Glycerol/therapeutic use , Humans , Rectovaginal Fistula/etiology , Vesicovaginal Fistula/etiologyABSTRACT
A regression of tumour growth is observed when alkoxyglycerols are administered prior to radiation treatment of patient suffering from cancer of the uterine cervix. This regression has been demonstrated by a change in the quotient between the incidence of early and advanced stages.
Subject(s)
Ethers/therapeutic use , Glycerol/analogs & derivatives , Uterine Neoplasms/drug therapy , Capsules , Ethers/administration & dosage , Female , Glycerol/administration & dosage , Glycerol/therapeutic use , Humans , Premedication , Remission, Spontaneous , Uterine Neoplasms/radiotherapyABSTRACT
The incidence of injuries following intracavitary and external radiation therapy is markedly decreased in all stages of the disease by the administration of alkoxyglycerols. Complex injuries (due to radiation injury and tumour growth in combination) were reduced to about 1/3 in a group receiving alkoxyglycerols prophylactically, i.e. before, during and after radiation treatment, when compared with a control group. Using non-prophylactic administration of alkoxyglycerols, i.e. during and after radiation treatment, no effect was observed on complex injuries, while--as for the prophylactic group--the injuries due to radiation only, were significantly decreased. The use of so called "increased amount" of radium in the intracavitary irradiator was followed by an unexpectedly high incidence of radiation injuries, which was considerably reduced, however, by alkoxyglycerols, especially when administered prophylactically.
