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1.
Oral Oncol ; 94: 41-46, 2019 07.
Article in English | MEDLINE | ID: mdl-31178211

ABSTRACT

OBJECTIVES: Cross sectional imaging is mandatory for oral cavity and oropharynx head and neck squamous cell carcinoma's (ooSCC) local extension and TNM staging. However a complex anatomy and frequent dental metallic artifacts make it difficult. This study assesses the clinical benefit of "Mouth Open with Tongue Extended" dynamic maneuver at CT (CTmote) as compared to the conventional CT (CTconv) and MRI. MATERIAL: Retrospectively, 58 patients with histologically proven ooSCC (oral cavity: 34; oropharynx: 24) were included in the study. All had endoscopy with biopsies, MRI, CTconv and an CTmote acquisitions. Data were splitted in 3 datasets and 2 independent radiologists performed readings blindly. Gold standard was pTNM in 31% of cases; otherwise cTNM obtained at multidisciplinary team meeting with endoscopy and mapping biopsies were used. RESULTS: CTmote was feasible for all patients including those already treated by surgery or radiotherapy. Exact TNM staging was obtained in 68%, 83%, 83% for CTconv, CTmote and MRI respectively. The best exam ratings at paired wise comparisons were 3%, 47%, 50% for CTconv, CTmote and MRI respectively. CTmote and MRI observer agreements, image quality and confidence ratings, were comparable and higher compared to CTconv (p < 0.001). CONCLUSIONS: CTmote improves oral cavity and oropharynx tumour stage assessment compared to CTconv with performances close to those of MRI examination. In clinical practice, combining both CT with MOTE maneuver and MRI seems to be the optimal imaging strategy for local staging.


Subject(s)
Magnetic Resonance Imaging/methods , Mouth Neoplasms/diagnostic imaging , Neoplasm Staging/methods , Oropharyngeal Neoplasms/diagnostic imaging , Squamous Cell Carcinoma of Head and Neck/diagnostic imaging , Tomography, X-Ray Computed/methods , Female , Humans , Male , Middle Aged , Mouth Neoplasms/pathology , Oropharyngeal Neoplasms/pathology , Retrospective Studies , Squamous Cell Carcinoma of Head and Neck/pathology
3.
Microbiology (Reading) ; 149(Pt 9): 2645-2652, 2003 Sep.
Article in English | MEDLINE | ID: mdl-12949188

ABSTRACT

The phosphoenolpyruvate : sugar phosphotransferase system (PTS) catalyses translocation with concomitant phosphorylation of sugars and hexitols and it regulates metabolism in response to the availability of carbohydrates. The PTS forms an interface between energy and signal transduction and its inhibition is likely to have pleiotropic effects. It is present in about one-third of bacteria with fully sequenced genomes, including many common pathogens, but does not occur in eukaryotes. Enzyme I (ptsI) is the first component of the divergent protein phosphorylation cascade. ptsI deletions were constructed in Salmonella typhimurium, Staphylococcus aureus and Haemophilus influenzae and virulence of the mutants was characterized in an intraperitoneal mouse model. The log(attenuation) values were 2.3, 1.4 and 0.9 for the Sal. typhimurium, Sta. aureus and H. influenzae ptsI mutants, respectively. The degree of attenuation is correlated with the complexity of the respective PTS, which comprises approximately 40 components in Sal. typhimurium, but only 5 in H. influenzae.


Subject(s)
Phosphoenolpyruvate Sugar Phosphotransferase System/metabolism , Phosphotransferases (Nitrogenous Group Acceptor)/metabolism , Salmonella typhimurium/enzymology , Animals , Biological Transport , Mice , Mice, Inbred BALB C , Models, Animal , Phosphoenolpyruvate Sugar Phosphotransferase System/genetics , Phosphotransferases/metabolism , Salmonella typhimurium/metabolism
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