1.
J Med Chem
; 19(10): 1180-6, 1976 Oct.
Article
in English
| MEDLINE
| ID: mdl-994147
ABSTRACT
A series of esters of adenosine-5'-carboxylic acid has been prepared. Most of the compounds were nontoxic, causing prolonged increases in coronary sinus PO2 when administered to anesthetized dogs; the ethyl ester was most active. Nitrosation and oxidation of the ethyl ester 12 gave respectively inactive inosine ethyl ester 30 and the fairly active N1-oxide ethyl ester 29.
Subject(s)
Adenosine/analogs & derivatives , Adenosine/chemical synthesis , Adenosine/pharmacology , Alkylation , Animals , Coronary Vessels/drug effects , Dogs , Esterification , Oxygen/blood , Structure-Activity Relationship
2.
Toxicol Appl Pharmacol
; 18(1): 60-8, 1971 Jan.
Article
in English
| MEDLINE
| ID: mdl-5542834