ABSTRACT
10 patients with chronic adult periodontitis who had greater than 1 tooth with infra-bony pockets were treated at the test defects by periodontal flap procedures with implantation of hydroxylapatite particles; the control defects were treated by the same surgical procedures but without the implant. A total of 58 test defects and 59 control defects were treated. Each defect had measurements carried out at given sites on the involved tooth surfaces, the sites being considered for subsequent tabulation purposes under the category of shallow (less than 3 mm) moderate (3-6 mm) and deep (greater than 6 mm) initial pocket depths. There were 146 and 152 shallow sites, 216 and 241 moderate sites and 140 and 133 deep sites, at test and control sites, respectively. Measurements of recession, probing pocket depths and probing attachment levels were made at 6 months and 1, 2, 3 and 4 years. At all sites over the period of the study, for the moderate and deep initial pockets there was a significant reduction in probing depths and an increase in the probing attachment levels. At the 4th year of assessment for the initially deep pockets, the reduction in probing depths was significantly greater for the sites treated with the implant material. In view of the difficult clinical problem posed by the treatment of teeth with deeper periodontal bone defects, further research using either this type of implant material or similar material should be considered.
Subject(s)
Alveolar Bone Loss/surgery , Ceramics , Dental Implants , Hydroxyapatites , Periodontal Pocket/surgery , Adult , Alveolar Bone Loss/pathology , Ceramics/chemistry , Dental Plaque/prevention & control , Dental Scaling , Durapatite , Female , Follow-Up Studies , Gingival Recession/pathology , Humans , Hydroxyapatites/chemistry , Male , Middle Aged , Periodontal Pocket/pathology , Periodontitis/surgery , Root Planing , Subgingival Curettage , Wound HealingABSTRACT
514 patients with benign breast disease provided records from multicentre studies in the U.S.A. Results showed that a high proportion responded with either decrease or elimination of symptoms, response usually being apparent 15 to 45 days after commencing treatment. Dosage schedules varied between 50 and 400 mg danazol daily and length of treatment between 15 and 196 days. There was a tendency for patients with more severe symptoms to respond better to the higher dosages, and for the elimination rate for all grades of severity to improve with time. Side effects were not severe, and of the expected type including weight gain, oiliness of skin and hair, and acne.
Subject(s)
Breast Diseases/drug therapy , Danazol/therapeutic use , Pregnadienes/therapeutic use , Clinical Trials as Topic , Danazol/administration & dosage , Dose-Response Relationship, Drug , Double-Blind Method , Drug Administration Schedule , Female , Humans , Menstruation/drug effectsABSTRACT
The authors have correlated the findings of thermography and radiology in some inflammatory lesions. The two investigations are complementary. Thermography demonstrates changes of vascularity in the acute phase of a lesion whereas radiology is of value in showing structural changes.
