ABSTRACT
A 60-year-old man was hospitalised with persistent fever, arm pain, dry cough and cholestasis. Diagnostic workup was remarkable for elevated inflammatory markers. Infectious diseases and autoimmune screening were negative. Imaging modalities excluded a neoplastic aetiology. Liver biopsy was negative for granulomatous or lymphomatous infiltrations. Giant cell arteritis (GCA) was suspected, but temporal artery Doppler ultrasound and biopsy were non-diagnostic. A positron emission tomography scan showed intense metabolic uptake in large vessels suggesting the diagnosis of GCA. Prednisolone was initiated with clinical and analytical improvement. At 1-year follow-up, there were no relapses and the patient remains symptom free.
Subject(s)
Aspirin/therapeutic use , Giant Cell Arteritis/diagnostic imaging , Giant Cell Arteritis/drug therapy , Prednisolone/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal , Cholestasis , Cough , Diagnosis, Differential , Drug Therapy, Combination , Fever of Unknown Origin , Glucocorticoids/therapeutic use , Humans , Male , Middle Aged , Positron-Emission TomographyABSTRACT
A 73-year-old man was transferred to the neurosurgery ward, with a presumptive diagnosis of cerebral abscess. The case was also discussed with the internists as internal medicine consultants. The neurosurgeons pointed out a right temporal lobe abscedated lesion on CT, but we noticed that the hypodense attenuation that usually surrounds the abscess wall (vasogenic oedema) extended to a broader, well-delimitated area, suggesting medium cerebral artery territory. The patient had left-sided hemiplegia with a confusional state and low-grade fever. Considering possible haematogenous dissemination, an echocardiography was performed, confirming mitral endocarditis. Blood cultures and aspirated pus isolated Escherichia coli. Investigating the patient's medical history, we learned he had been submitted to bladder catheterisation 7 weeks before for acute urinary retention due to benign prostatic hyperplasia, and empirically medicated for urinary tract infection. E. coli had also been isolated in a urine specimen at the time. The clinical history of the patient cancelled the pathogenesis of cerebral abscess.
Subject(s)
Brain Abscess/diagnosis , Endocarditis, Bacterial/diagnosis , Escherichia coli Infections/diagnosis , Mitral Valve/microbiology , Urinary Tract Infections/diagnosis , Aged , Anti-Bacterial Agents/therapeutic use , Brain Abscess/drug therapy , Brain Abscess/microbiology , Diagnosis, Differential , Endocarditis, Bacterial/drug therapy , Endocarditis, Bacterial/microbiology , Escherichia coli Infections/drug therapy , Humans , Male , Urinary Tract Infections/drug therapy , Urinary Tract Infections/microbiologyABSTRACT
Cardiogenic flash pulmonary oedema is a common and potentially fatal cause of acute respiratory distress. Although it often results from acute decompensated heart failure, abrupt-onset aortic regurgitation can sharply rise cardiac filling pressure and, consequently, pulmonary venous pressure, leading to rapid fluid accumulation in the interstitial and alveolar spaces. We report a case of a 64-year-old woman admitted to the emergency department with a flash pulmonary oedema; a careful clinical investigation subsequently revealed a rare aetiology for this 'common' presentation. After a detailed auscultation that unmasked a diastolic cardiac murmur, an acute severe aortic insufficiency was further confirmed by echocardiography, showing inflammation and thickening of the entire aorta wall. The patient was submitted to valve replacement surgery, and histological examination, to our surprise, showed features of aortitis, remarkable for the presence of giant cells. A diagnosis of idiopathic aortitis versus inaugural giant cell arteritis was proposed and treatment started with corticosteroids.
Subject(s)
Aortic Valve Insufficiency/diagnostic imaging , Aortitis/pathology , Giant Cell Arteritis/pathology , Pulmonary Edema/diagnosis , Adrenal Cortex Hormones/therapeutic use , Aortic Valve Insufficiency/surgery , Aortitis/complications , Aortitis/drug therapy , Echocardiography , Emergency Service, Hospital , Female , Giant Cell Arteritis/complications , Giant Cell Arteritis/drug therapy , Heart Valve Prosthesis Implantation , Humans , Middle Aged , Pulmonary Edema/etiologyABSTRACT
PURPOSE: To describe a clinical case and literature review of Whipple disease. METHODS: A 65-year-old male with bilateral decreased visual acuity for 3 weeks as well as bilateral hypoacusia, vertigo, disequilibrium, headache and decreased strength in the right upper limb for 4 months. The clinical work-up revealed a bilateral panuveitis and an ischemic cerebellar stroke. RESULT: The diagnosis of Whipple disease was confirmed by histopathological analysis of adenopathy. The patient was treated with cortico-antibiotic therapy with significant clinical improvement. CONCLUSION: Although rare, Whipple disease is potentially fatal if left untreated, it must be always be taken into consideration before any panuveitis of an unknown cause, even in the absence of gastrointestinal symptoms.
ABSTRACT
We present a rare case of Stewart-Treves syndrome characterized by a diffuse angiosarcoma of the leg in a 22-year-old man with a history of chronic lymphedema due to Klippel-Trénaunay-Weber syndrome. He underwent limb disarticulation and medical treatment with cycles of doxorubicin, oral thalidomide and sunitinib with a very good response after 12 months of follow-up.
