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Angew Chem Int Ed Engl
; 48(14): 2518-21, 2009.
Article
in English
| MEDLINE
| ID: mdl-19235824
ABSTRACT
Finding the few: Cell-surface proteins are useful disease biomarkers, but current high-throughput methods are limited to detecting cells expressing more than several hundred proteins. Enzymatic amplification in microfluidic droplets (see picture) is a high-throughput method for detection and analysis of cell-surface biomarkers expressed at very low levels on individual human cells. Droplet optical labels allow concurrent analysis of several samples.