ABSTRACT
Two hundred and seven patients with active symptoms of allergic conjunctivitis were studied in a four-week multicentre double blind, double dummy, clinical trial comparing efficacy and safety of nedocromil sodium eye drops with oral astemizole, placebo, and the combined active treatments. Clinical signs were evaluated by clinicians after 1, 2 and 4 weeks, while symptoms were recorded by patients on daily diary cards. Overall opinions were recorded at the end of treatment. Nedocromil sodium eye drops and astemizole, alone or combined, significantly reduced ocular symptoms when compared to placebo (diary card total symptom score and patients' opinion). In the clinicians' opinion nedocromil sodium alone or combined (but not astemizole alone) significantly decreased ocular symptoms when compared to placebo. All treatments were safe and well tolerated, drowsiness being the most frequent side effect observed in patients treated with astemizole. These results indicate the effectiveness of nedocromil sodium eye drops in the treatment of seasonal allergic conjunctivitis.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Astemizole/therapeutic use , Conjunctivitis, Allergic/drug therapy , Quinolones/therapeutic use , Adolescent , Adult , Aged , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Astemizole/adverse effects , Child , Double-Blind Method , Drug Therapy, Combination , Female , Humans , Male , Middle Aged , Nedocromil , Quinolones/adverse effectsABSTRACT
Two groups of monocular strabismic patients were followed-up by means of both PL and orthoptic examinations. The first group underwent a full-day occlusion except 1 to 4 hours; the second was occluded less than 4 hours per day. The first treatment regimen proved to be faster in getting pseudo-isoacuity and alternating fixation, but was followed by relative occlusion amblyopia and/or shifting of the dominant eye in three patients. PL techniques proved to be particularly useful in strictly monitoring these patients.
Subject(s)
Amblyopia/physiopathology , Strabismus/physiopathology , Visual Acuity/physiology , Amblyopia/therapy , Follow-Up Studies , Humans , Infant , Orthoptics , Sensory Deprivation , Strabismus/therapy , Vision TestsABSTRACT
The visual evoked potentials (VEP pattern) were studied in a group of 18 type I diabetic subjects. Age of patients, duration of disease, glicosilated hemoglobin, blood sugar were correlated with the modifications in latency and amplitude of visual evoked responses.
Subject(s)
Diabetic Neuropathies/physiopathology , Evoked Potentials, Visual , Optic Nerve/physiopathology , Adult , Humans , Middle AgedABSTRACT
The clinical and anatomopathological features of angioma of the iris are described and the relevant literature is briefly reviewed. A personal case in a 47-year-old woman is presented. Reference is made to the fact that, unlike many of the cases in the literature, histological confirmation of the diagnosis was obtained. Mention is also made of the importance of fluorescein angiography in the differential diagnosis of other forms, particularly melanoma. Fluorescein angiography, for the first time applied to angioma of the iris in the present case, enabled a satisfactory result (follow-up of 8 months) to be obtained by conservative iridectomy, in line with the recent approach to the management of this form.
