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1.
Ann Plast Surg ; 78(6): 629-632, 2017 Jun.
Article in English | MEDLINE | ID: mdl-27922894

ABSTRACT

BACKGROUND: Breast augmentation is one of the most commonly performed aesthetic surgery procedures worldwide. Bacterial contamination is of paramount concern due to its role in biofilm formation and capsular contracture. Plastic surgeons have adopted a variety of perioperative interventions in efforts to reduce implant contamination, however definitive evidence supporting these practices is lacking. OBJECTIVE: The goal of this study was to assess current practice patterns aimed at reducing implant-related infections in breast augmentation and comparing them to current evidence-based medicine recommendations. METHODS: A 20-question survey assessing practices aimed at preventing breast implant associated infections was generated and distributed via SurveyMonkey to members of the American Society of Plastic Surgery whose electronic mail addresses were listed on the American Society of Plastic Surgery member website in April 2015. RESULTS: A total of 253 responses were received from the survey. Of the respondents, 81% were in private practice. Respondents averaged 21 ± 9 years in practice, and 69 ± 111 breast augmentations performed per year. A majority of surgeons used Chlorhexidine to prepare the surgical site (45%) and triple antibiotic solution both as a soak for the implant before placement (40%) as well as for implant pocket irrigation (47%). A no-touch technique using the Keller Funnel was adopted by 42% of surgeons. Regarding antibiotic use in the postoperative period, first-generation cephalosporins were used by the majority of respondents (79%), and the most common duration was for 4 to 6 days (45%). CONCLUSIONS: Although there is heterogeneity in specific aspects of antimicrobial prophylaxis during breast augmentation, there is a clear trend toward practice modification geared towards preventing bacterial contamination in breast augmentation. Surgeons may benefit from high-level studies designed to create standardized evidence-based practice guidelines.


Subject(s)
Anti-Infective Agents/administration & dosage , Antibiotic Prophylaxis , Breast Implants/microbiology , Infection Control/methods , Mammaplasty/methods , Practice Patterns, Physicians'/statistics & numerical data , Prosthesis-Related Infections/prevention & control , Surgical Wound Infection/prevention & control , Female , Humans , Surveys and Questionnaires , Treatment Outcome , United States
2.
Ann Plast Surg ; 78(2): 153-156, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27464530

ABSTRACT

BACKGROUND: Implant-based breast reconstruction is commonly performed by plastic surgeons worldwide. Bacterial contamination is of paramount concern because of its role in biofilm formation and capsular contracture. Plastic surgeons have adopted a variety of perioperative interventions in efforts to reduce implant contamination; however, definitive evidence supporting these practices is lacking. OBJECTIVE: The goal of this study was to assess current practice patterns aimed at reducing implant-related infections. METHODS: A 20-question survey assessing practices aimed at preventing breast implant-associated infections was generated and distributed via SurveyMonkey to members of the American Society of Plastic Surgery whose e-mail addresses were listed on the American Society of Plastic Surgery member Web site in April 2015. RESULTS: A total of 1979 invitations to participate in the survey were sent, and 253 responses were received during the 4-month study period. Of respondents, 81% were in private practice. Respondents averaged 21 ± 9 years in practice, and 34 ± 50 implant-based breast reconstructions were performed per year. A majority of surgeons used chlorhexidine to prepare the surgical site (52%), a triple antibiotic soak for the implant prior to placement (50%) and povidone-iodine for implant pocket irrigation (44%). A no-touch technique utilizing the Keller funnel was adopted by 69% of surgeons. Regarding antibiotic use in the postoperative period, first-generation cephalosporins (eg, cephalexin, cefadroxil) were used by a majority of surgeons (84%), and the most common duration was until drain removal (45%). CONCLUSIONS: There is considerable heterogeneity in surgical practices aimed at preventing bacterial contamination in implant-based breast reconstruction. Surgeons may benefit from high-level studies designed to create standardized evidence-based practice guidelines.


Subject(s)
Breast Implantation/instrumentation , Breast Implants/microbiology , Infection Control/methods , Perioperative Care/methods , Practice Patterns, Physicians'/statistics & numerical data , Prosthesis-Related Infections/prevention & control , Breast Implantation/methods , Female , Health Care Surveys , Humans , Infection Control/statistics & numerical data , Perioperative Care/statistics & numerical data , United States
3.
J Craniofac Surg ; 25(6): 1953-8, 2014 Nov.
Article in English | MEDLINE | ID: mdl-25329851

ABSTRACT

OBJECTIVE: Vascularized bone flaps are currently indicated for reconstructing mandibular defects 6 cm or larger. This technique can result in donor-site morbidity and requires microsurgery. To explore alternative methods of mandibular reconstruction, we sought to compare bone graft obtained with the reamer-irrigator-aspirator (RIA) device with the free fibula (FF) flap for the reconstruction of a critical-sized mandibular defect. METHODS: Sixteen 3-month-old Yorkshire pigs underwent 6-cm full-thickness resection of the left mandible. For the FF group (n = 8), an osseous FF flap was raised from the left leg and placed into the defect. For the RIA group (n = 8), a RIA Instrument Set was used on the ipsilateral femur to ream the femoral canal and harvest RIA putty. This putty containing medullary bone marrow contents and cortical bone was packed into the defect. At the study end point, volumetric, biomechanical, and histologic analyses were performed. RESULTS: Operative times were significantly shorter in the RIA group (RIA,126 [30] min; FF, 346 [50] min; P < 0.05). Biomechanical testing of reconstructed sites showed no significant difference in maximum fracture loads between both groups (RIA, 468 [97] N; FF, 689 [262] N; P = 0.11). Mean (SD) volume ratio of bone growth at the reconstructed sites was comparable between both groups (RIA, 71% [4.5%]; FF, 72% [3.3%]; P = 0.60). Equal bone quality was confirmed histologically. CONCLUSIONS: The RIA technique significantly reduces operative time and provides bone of equal strength and histologic quality to FF flap reconstruction in a large animal model. The RIA method may represent an efficient technique for the reconstruction of craniomaxillofacial defects.


Subject(s)
Bone Transplantation/methods , Fibula/transplantation , Free Tissue Flaps/transplantation , Mandibular Diseases/surgery , Plastic Surgery Procedures/methods , Animals , Biomechanical Phenomena , Bone Marrow Transplantation/instrumentation , Bone Marrow Transplantation/methods , Bone Transplantation/instrumentation , Femur/surgery , Free Tissue Flaps/pathology , Mandibular Diseases/pathology , Mandibular Fractures/etiology , Mandibular Reconstruction/methods , Models, Animal , Operative Time , Osteogenesis/physiology , Swine , Time Factors , Tissue and Organ Harvesting/instrumentation , Transplant Donor Site/surgery , Wound Healing/physiology
4.
J Reconstr Microsurg ; 30(4): 241-8, 2014 May.
Article in English | MEDLINE | ID: mdl-24590323

ABSTRACT

Vascularized bone flaps are the well-known standards of care for reconstruction of segmental mandibular defects ≥ 6 cm. We developed a large animal critical-sized mandibular defect model in which osseous free fibula flaps were used for reconstruction.In this study a total of eight 3-month-old Yorkshire pigs underwent 6 cm full-thickness resection of the left hemimandible. An osseous free fibula flap from the left leg was harvested and contoured to the mandibular defect. Bone placement and plate position was confirmed with fluoroscopy. Animals were followed with serial radiographs and clinical evaluations.Free fibulas were transferred successfully in all eight animals. The average operative time was 346 minutes, and the average flap ischemia time was 86 minutes. The average volume ratio of reconstructed hemimandibles to nonoperated control hemimandibles was 0.72 ± 0.33. The average maximum fracture load was 689 ± 262 N, and the average ratio of biomechanical fracture load for these samples compared with contralateral control hemimandibles was 0.88 ± 0.25.It is concluded that the porcine osseous free fibula flaps can be reliably harvested and viably transferred to critical-sized posterior mandibular defects with acceptable long-term results. The described microsurgical large animal model is acceptable for use in craniomaxillofacial experimentation.


Subject(s)
Fibula/transplantation , Free Tissue Flaps/blood supply , Mandible/surgery , Plastic Surgery Procedures/methods , Animals , Bone Plates , Bone Transplantation , Female , Fibula/pathology , Graft Survival , Image Processing, Computer-Assisted , Male , Mandible/pathology , Mandibular Reconstruction/methods , Models, Animal , Operative Time , Swine , Treatment Outcome
5.
J Oral Maxillofac Surg ; 72(9): 1788-800, 2014 Sep.
Article in English | MEDLINE | ID: mdl-24656428

ABSTRACT

PURPOSE: Full facial osteomyocutaneous transplantation requires correct 3-dimensional (3D) alignment of donor osseous structures to a new cranial base with minimal reference points and 6 degrees of potential movement. We investigated whether computer-assisted design and manufacturing (CAD/CAM) could enable accurate placement of the facial skeleton. MATERIALS AND METHODS: A prospective single-cohort study of Le Fort III-based maxillary-mandibular segment allotransplantation was performed in 5 cadaver pairs and 1 clinical pair. The osteotomies were modeled using computed tomography (CT) data and 3D modeling software and then translated to the donor-recipient pairs using surgical navigation and osteotomy cutting guides. The predicted values were calculated about all rotational axes (pitch, yaw, and roll) and along all translational axes (vertical, horizontal, and anteroposterior) and used as the independent variable. The primary outcome variable of the actual postoperative CT values was compared for fidelity to the prediction using the intraclass correlation coefficient (ICC). The similarity to the donor versus recipient values was calculated as a secondary independent variable, and both predicted and actual measurements were compared with it as a percentage. RESULTS: The postoperative fidelity to the plan was adequate to excellent (ICC 0.520 to 0.975) with the exception of lateral translation (2.94 ± 1.31 mm predicted left vs 3.92 ± 2.17 mm right actual displacement; ICC 0.243). The predicted and actual values were not consistently skewed toward the donor or recipient values. CONCLUSIONS: We have demonstrated a novel application of CAD/CAM that enables orthognathic alignment of a maxillary-mandibular segment to a new cranial base. Quantification of the alignment in all 6 degrees of freedom delivers precise control compared with the planned changes and allows postoperative quality control.


Subject(s)
Allografts/transplantation , Computer-Aided Design , Face/surgery , Facial Transplantation/methods , Orthognathic Surgical Procedures/methods , Surgery, Computer-Assisted , Bone Transplantation/methods , Cadaver , Cephalometry/methods , Cohort Studies , Forecasting , Humans , Imaging, Three-Dimensional/methods , Mandible/transplantation , Maxilla/transplantation , Nasal Bone/transplantation , Osteotomy, Le Fort/methods , Osteotomy, Sagittal Split Ramus/methods , Patient Care Planning , Prospective Studies , Rotation , Software , Tomography, X-Ray Computed/methods , User-Computer Interface , Zygoma/transplantation
6.
J Reconstr Microsurg ; 30(2): 115-20, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24163222

ABSTRACT

Use of the ulnar forearm flap (UFF) is limited by concerns for ulnar nerve injury and impaired perfusion in the donor extremity. Twenty UFFs were performed over a 6-year period. All patients underwent postoperative bilateral upper extremity arterial duplex studies. A subset of postoperative patients (n = 10) also had bilateral upper extremity sensory and motor evaluations, and functional evaluation via the Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH). Motor function was tested by digital and key grip dynamometry. Ulnar nerve sensation was tested by evaluation of one- and two-point perceived pressure thresholds and two-point discrimination using the Pressure-Specified Sensory Device (Sensory Management Services, LLC, Baltimore, MD). All UFFs were viable postoperatively. Mean follow-up was 28.8 months for vascular studies and 45.3 months for motor, sensory, and QuickDASH evaluations. Although mid and distal radial artery flow velocities were significantly higher in donor versus control extremities evaluated at less than 1 year postoperatively, there was no significant difference in extremities evaluated at later time points. Digital pressures, grip strength, key pinch strength, and ulnar sensation were equivalent between donor and control extremities. The mean QuickDASH score was 17.4 ± 23.8. The UFF can be harvested reliably and long-term follow-up shows no evidence of impaired vascular, motor, or sensory function in the donor extremity.


Subject(s)
Forearm/blood supply , Head and Neck Neoplasms/surgery , Tissue and Organ Harvesting/methods , Transplant Donor Site/physiopathology , Blood Flow Velocity , Disability Evaluation , Female , Forearm/innervation , Forearm/surgery , Free Tissue Flaps/blood supply , Graft Survival , Hand Strength , Humans , Male , Radial Artery/physiopathology , Plastic Surgery Procedures/methods , Recovery of Function , Sensory Thresholds , Surveys and Questionnaires , Time Factors , Ulnar Nerve/physiopathology
7.
Ann Plast Surg ; 72(4): 467-8, 2014 Apr.
Article in English | MEDLINE | ID: mdl-23759967

ABSTRACT

In preparation for the donor and recipient facial vascularized composite allotransplant (VCA), the marginal mandibular nerve branch should be identified and co-apted to the recipient's nerve to allow for re-innervation. We describe a method to identify the marginal mandibular branch of the facial nerve in facial VCA donors and recipients. Through cadaver dissections, the posterior facial vein was traced posteriorly to identify the marginal mandibular branch of the facial nerve. In cases where we were unable to use this relationship, we found the posterior facial venous system to be diminutive. This technique is useful for finding the marginal mandibular branch when dissecting anterograde to the parotid gland.


Subject(s)
Face/blood supply , Facial Nerve/anatomy & histology , Mandibular Nerve/anatomy & histology , Face/innervation , Facial Nerve/surgery , Facial Transplantation , Humans , Mandibular Nerve/surgery , Veins/anatomy & histology
8.
Cells Tissues Organs ; 198(2): 87-98, 2013.
Article in English | MEDLINE | ID: mdl-24021248

ABSTRACT

The translation of tissue engineering approaches to the clinic has been hampered by the inability to find suitable multipotent cell sources requiring minimal in vitro expansion. Enhanced bone marrow (eBM), which is obtained by reaming long bone medullary canals and isolating the solid marrow putty, has large quantities of stem cells and demonstrates significant potential to regenerate bone tissues. eBM, however, cannot impart immediate load-bearing mechanical integrity or maintain the gross anatomical structure to guide bone healing. Yet, its putty-like consistency creates a challenge for obtaining the uniform seeding necessary to effectively combine it with porous scaffolds. In this study, we examined the potential for combining eBM with mechanically strong, osteoinductive trabecular bone scaffolds for bone regeneration by creating channels into scaffolds for seeding the eBM. eBM was extracted from the femurs of adult Yorkshire pigs using a Synthes reamer-irrigator-aspirator device, analyzed histologically, and digested to extract cells and characterize their differentiation potential. To evaluate bone tissue formation, eBM was seeded into the channels in collagen-coated or noncoated scaffolds, cultured in osteogenic conditions for 4 weeks, harvested and assessed for tissue distribution and bone formation. Our data demonstrates that eBM is a heterogenous tissue containing multipotent cell populations. Furthermore, coating scaffolds with a collagen hydrogel significantly enhanced cellular migration, promoted uniform tissue development and increased bone mineral deposition. These findings suggest the potential for generating customized autologous bone grafts for treating critical-sized bone defects by combining a readily available eBM cell source with decellularized trabecular bone scaffolds.


Subject(s)
Bone Marrow/physiology , Bone Transplantation , Tissue Engineering/methods , Tissue Scaffolds/chemistry , Animals , Bone Marrow/surgery , Bone and Bones/cytology , Bone and Bones/diagnostic imaging , Cattle , Cell Differentiation , Cell Lineage , Cell Movement , Cell Survival , Osteogenesis , Rats , Sus scrofa , X-Ray Microtomography
9.
Transplantation ; 96(3): 267-73, 2013 Aug 15.
Article in English | MEDLINE | ID: mdl-23839001

ABSTRACT

BACKGROUND: T regulatory cells (Tregs) have been associated with prolonged allograft survival and tolerance across a wide variety of species and organ types. We used our nonhuman primate model of facial vascularized composite allotransplantation (VCA) to study the association of Tregs with graft outcomes. METHODS: We quantified Tregs in peripheral blood and allograft biopsies from nonhuman primates after heterotopic partial facial segment allotransplantation from major histocompatibility complex class I-mismatched donors using flow cytometry and immunohistochemistry. Immunosuppression consisted of tacrolimus and mycophenolate mofetil without induction or depletional therapies. Circulating and graft skin Treg values were compared with graft outcomes and with histologic grade from concurrent biopsies. RESULTS: Treg proportion in peripheral blood ranged from 0.156% to 9.00% with a mean of 3.34%±0.22%. FoxP3 staining was observed in 3 of 29 graft biopsies. Median circulating Treg value did not predict time to Banff grade II rejection (hazard ratio, 0.9; confidence interval, 0.4-2.2) or graft loss (hazard ratio, 0.5; confidence interval, 0.01-5.3). Animals that experienced rejection did not have significantly different peripheral blood or graft skin Treg values from those that did not. Biopsy specimens with grade I or II rejection were more likely to contain Tregs (25% vs. 0%; P=0.044) despite no difference in concurrent circulating Tregs (3.56% vs. 3.36%; P=0.704). CONCLUSIONS: These findings in a clinically relevant model suggest that Tregs may have limited prognostic value with standard immunosuppressive protocols used in VCA. Further studies are necessary to determine the specific role of Tregs in VCA and any role of Treg monitoring in clinical practice.


Subject(s)
Graft Rejection/immunology , T-Lymphocytes, Regulatory/immunology , Vascularized Composite Allotransplantation/adverse effects , Animals , Graft Rejection/pathology , Immunosuppressive Agents/therapeutic use , Macaca fascicularis
10.
Plast Reconstr Surg ; 131(2): 253-257, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23357986

ABSTRACT

BACKGROUND: The anatomy of the facial nerve and its branches has been well documented. The course of the extratemporal facial nerve, its anatomical planes, and the surface landmarks of the temporal division and marginal mandibular division are well known. However, the surface landmark of the middle division of the facial nerve has not been studied to date. METHODS: Eighteen hemifacial dissections in 10 fresh human cadavers were performed through a preauricular face-lift incision. An 18-gauge needle with brilliant green dye was used to mark the nerve through the skin before dissection. The exact location of the middle division branches of the facial nerve was documented in relation to the transcutaneous marking. RESULTS: The middle division branches of the facial nerve were found to lie at a mean of 2.3 mm from the tattooed point, with a range of 0 to 6 mm. A nerve branch was found directly tattooed by the needle seven of 18 times, inferior to the tattoo five of 18 times, and superior to the tattoo six of 18 times. CONCLUSIONS: The zygomatic/buccal motor branch that innervates the zygomaticus major muscle can be reliably found at the midway point on a line drawn from the root of the helix and the lateral commissure of the mouth. This study will help guide surgeons to the middle division of the facial nerve as it applies to facial surgery.


Subject(s)
Facial Nerve/anatomy & histology , Cadaver , Humans
11.
Plast Reconstr Surg ; 131(2): 241-251, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23076416

ABSTRACT

BACKGROUND: The central face high-energy avulsive injury has been frequently encountered and predictably managed at the R Adams Cowley Shock Trauma Center. However, despite significant surgical advances and multiple surgical procedures, the ultimate outcome continues to reveal an inanimate, insensate, and suboptimal aesthetic result. METHODS: To effectively address this challenging deformity, a comprehensive multidisciplinary approach was devised. The strategy involved the foundation of a basic science laboratory, the cultivation of a supportive institutional clinical environment, the innovative application of technologies, cadaveric simulations, a real-time clinical rehearsal, and an informed and willing recipient who had the characteristic deformity. RESULTS: After institutional review board and organ procurement organization approval, a total face, double jaw, and tongue transplantation was performed on a 37-year-old man with a central face high-energy avulsive ballistic injury. CONCLUSIONS: This facial transplant represents the most comprehensive transplant performed to date. Through a systematic approach and clinical adherence to fundamental principles of aesthetic surgery, craniofacial surgery, and microsurgery and the innovative application of technologies, restoration of human appearance and function for individuals with a devastating composite disfigurement is now a reality. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V.


Subject(s)
Facial Injuries/surgery , Facial Transplantation , Jaw/transplantation , Multiple Trauma/surgery , Plastic Surgery Procedures/methods , Tongue/transplantation , Wounds, Gunshot/surgery , Adult , Humans , Male
12.
Plast Reconstr Surg ; 130(4): 815-823, 2012 Oct.
Article in English | MEDLINE | ID: mdl-22691839

ABSTRACT

BACKGROUND: With the transplantation of more extensive facial vascularized composite allografts, fundamental craniofacial and aesthetic principles become increasingly important. In addition, computer-assisted planning and intraoperative navigation may improve precision and efficiency in these complex procedures. METHODS: Ten mock face transplants were performed in 20 cadavers. The vascularized composite allograft consisted of all facial skin, mimetic muscles, the tongue, the midface by means of a Le Fort III osteotomy, and the mandible by means of sagittal split osteotomies. Craniofacial computed tomographic scans were obtained before and after the mock transplants. Surgical planning software was used to virtually plan the osteotomies, and a surgical navigation system guided the osteotomies intraoperatively. Cephalometric analyses were compared between the virtually planned transplants and the actual postoperative results. RESULTS: The combination of preoperative computerized planning and intraoperative guidance consistently produced a vascularized composite allograft that could be easily fixated to the prepared recipient, with only minimal burring of osteotomy sites necessary. Satisfactory occlusion was maintained, and postoperative computed tomography confirmed accurate skeletal fixation. Insignificant differences with regard to cephalometric analyses were noted when predicted and actual postoperative data were compared. CONCLUSIONS: The authors' experience treating severe craniofacial injury allowed consistent transfer of facial vascularized composite allografts, maintaining proper occlusion. Preoperative computer planning and intraoperative navigation ensured precise osteotomies and a good donor-recipient skeletal match, which greatly reduced the need for intraoperative adjustments and manipulation. This total facial vascularized composite allograft represents one of the most extensive described and is intended to represent a typical central facial demolition pattern.


Subject(s)
Facial Transplantation/methods , Orthognathic Surgical Procedures , Surgery, Computer-Assisted/methods , Tongue/surgery , User-Computer Interface , Cadaver , Cephalometry/methods , Fasciotomy , Humans , Imaging, Three-Dimensional , Osteotomy/methods , Plastic Surgery Procedures/methods , Sensitivity and Specificity , Skin Transplantation/methods , Transplantation, Homologous
13.
Plast Reconstr Surg ; 130(4): 824-834, 2012 Oct.
Article in English | MEDLINE | ID: mdl-22691842

ABSTRACT

BACKGROUND: Transplantation of a facial vascularized composite allograft is a highly complex procedure that requires meticulous planning and affords little room for error. Although cadaveric dissections are an essential preparatory exercise, they cannot simulate the true clinical experience of facial vascularized composite allograft recovery. METHODS: After obtaining institutional review board approval to perform a facial vascularized composite allograft research procurement, a 66-year-old, brain-dead donor was identified. The family graciously consented to donation of a total face, double jaw, and tongue allograft and multiple solid organs. RESULTS: A craniofacial computed tomographic angiogram was obtained preoperatively to define the vascular anatomy and facilitate virtual computerized surgical planning. The allograft was procured in 10 hours, with an additional 2 hours required for an open tracheostomy and silicone facial impression. The donor was coagulopathic throughout the recovery, resulting in an estimated blood loss of 1500 ml. Fluorescence angiography confirmed adequate perfusion of the entire allograft based on lingual and facial arterial and external jugular and thyrolinguofacial venous pedicles. The solid organ transplant team initiated abdominal organ isolation while the facial allograft procurement was in progress. After completion of allograft recovery, the kidneys and liver were recovered without complication. CONCLUSIONS: Before conducting a clinical face transplant, adequate preparation is critical to maximize vascularized composite allotransplantation outcomes and preserve solid organ allograft function. As more centers begin to perform facial transplantation, research procurement of a facial vascularized composite allograft offers a unique educational opportunity for the surgical and anesthesia teams, the organ procurement organization, and the institution.


Subject(s)
Face/surgery , Facial Transplantation/methods , Orthognathic Surgical Procedures , Tissue and Organ Procurement , Tongue/surgery , Aged , Anatomic Landmarks , Brain Death , Face/blood supply , Facial Expression , Fluorescein Angiography/methods , Humans , Models, Educational , Preoperative Care/methods , Time Factors , Tissue Donors , Transplantation, Homologous
14.
Eplasty ; 11: e43, 2011.
Article in English | MEDLINE | ID: mdl-22096615

ABSTRACT

OBJECTIVE: The senior author previously reported a case of rupture of the flexor policis longus tendon after volar plating of a distal radius fracture. We hypothesized that restoration of the pronator quadratus to its native position after plating might prevent this problem. METHODS: The authors report a new case of irritation of the flexor policis longus 2.5 years after volar plating of a distal radius fracture. The plate was in good contact with the bone, and the pronator quadratus had been restored to its native position. Despite this, there was a partial-thickness laceration of the tendon over the plate and a defect in the pronator quadratus muscle which had been between the plate and the tendon. RESULTS: The patient was treated with removal of the plate and repair of the tendon. She never lost function of the flexor policis longus tendon and has full function of her hand. CONCLUSIONS: The authors believe that restoration of the pronator quadratus to its native position after volar plating of a distal radius fracture does protect the overlying flexor tendons. Even with this step, tendon irritation can still occur. The authors advise their patients at the time of discharge from initial treatment of their distal radius fracture to be vigilant for any evidence of flexor tendon irritation and to return for evaluation if they have any suspicion of this.

15.
Atherosclerosis ; 205(2): 466-71, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19264305

ABSTRACT

BACKGROUND: The radial artery's (RA) tendency to spasm when used as a bypass graft may relate to features of the RA itself. We imaged RA conduits before and after CABG in order to characterize intimal abnormalities that might relate to the risk of spasm. METHODS: RA conduits from thirty-two CABG patients were imaged intraoperatively using catheter-based optical coherence tomography (OCT) and again on day 5 using 64-channel MDCT angiography. The change in luminal diameter between timepoints was measured in the proximal, mid and distal RA. "Spasm" was defined as focal or diffuse luminal narrowing to a diameter less than the target coronary. Lipid content in the RA was quantified by the degree of light attenuation on the OCT image. RESULTS: Postoperative spasm was diagnosed in 18 of 32 (56%) RA grafts with the distal RA showing the most severe change versus the mid and proximal portions (-24.1+/-43.2% vs. -15.3+/-40.7%, -9.0+/-42.5% change in diameter respectively, p<0.01). The degree of attenuation of the OCT signal produced by the RA was strongly correlated with % diameter change (R=0.64, p=0.0005) and was significantly more pronounced in grafts with spasm versus no spasm (-1.97+/-0.61mm(-1) vs. -0.81+/-0.57mm(-1), p<0.0001). Histology confirmed lipid deposits in areas of RA with strong attenuation. CONCLUSIONS: RA conduits otherwise considered acceptable for bypass grafting were often found by OCT imaging to have a substantial amount of lipid, which in turn strongly relates to the risk of postoperative spasm. Screening conduits based on characteristics of intimal quality may improve results following RA grafting.


Subject(s)
Radial Artery/pathology , Radial Artery/transplantation , Spasm/metabolism , Spasm/prevention & control , Tunica Intima/pathology , Aged , Angiography/methods , Biopsy , Coronary Angiography/methods , Female , Humans , Intraoperative Period , Lipids/chemistry , Male , Middle Aged , Postoperative Complications , Postoperative Period , Risk
16.
J Thorac Cardiovasc Surg ; 136(5): 1302-8, 2008 Nov.
Article in English | MEDLINE | ID: mdl-19026820

ABSTRACT

OBJECTIVE: Vasospasm is the primary obstacle to widespread adoption of the radial artery as a conduit in coronary artery bypass grafting. We used optical coherence tomography, a catheter-based intravascular imaging modality, to measure the degree of radial artery spasm induced by means of harvest with electrocautery or a harmonic scalpel in patients undergoing coronary artery bypass grafting. METHODS: Radial arteries were harvested from 44 consecutive patients with a harmonic scalpel (n = 15) or electrocautery (n = 29). Vessels were imaged before harvesting and after removal from the arm, with saphenous vein tracts serving as internal controls. Optical coherence tomographic findings for the degree of harvesting-induced injury were validated against histologic measures. RESULTS: Optical coherence tomographic measures of endovascular dimensions and injury correlated strongly with histologic findings. Mean luminal volume, a measure of vasospasm, decreased significantly less after harvesting with a harmonic scalpel (9% +/- 7%) than with electrocautery (35% +/- 6%, P = .015). Completely intact intima was present in 11 (73%) of 15 radial arteries harvested with a harmonic scalpel (73%) compared with 9 of 29 arteries harvested by means of electrocautery (31%, P = .011). Intraoperative flow measurements and patency rates at 5 days postoperatively were not significantly different among groups. CONCLUSIONS: Optical coherence tomography provides a level of speed and accuracy for quantifying endothelial injury and vasospasm that has not been described for any other modality, suggesting potential as an intraoperative quality assurance tool. Our optical coherence tomographic findings suggest that the harmonic scalpel induces less spasm and intimal injury compared with electrocautery.


Subject(s)
Coronary Artery Bypass/methods , Electrocoagulation , Radial Artery/transplantation , Spasm/prevention & control , Tissue and Organ Harvesting/methods , Tomography, Optical Coherence , Aged , Electrocoagulation/methods , Female , Humans , Intraoperative Complications/prevention & control , Male , Radial Artery/anatomy & histology , Tunica Intima/anatomy & histology , Vascular Patency
17.
Ann Thorac Surg ; 85(4): 1271-7, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18355508

ABSTRACT

BACKGROUND: Concerns about intimal disruption and spasm have limited enthusiasm for endoscopic radial artery harvest (ERAH), although the risk of these problems after this procedure remains uncertain. Radial artery conduits were screened intraoperatively before and after ERAH vs open harvest using catheter-based high-resolution optical coherence tomography (OCT) imaging. METHODS: Twenty-four cadavers and 60 coronary artery bypass graft (CABG) patients scheduled to receive a RA graft underwent OCT imaging before (in situ) and after (ex vivo) open harvest or ERAH. Spasm was quantified by the percentage change in luminal volume between images. Intimal disruption was classified as minor or severe depending on whether the defect was confined to branch ostia or involved the luminal surface. Histology was used to confirm OCT findings. RESULTS: Luminal volume significantly declined after harvest in all RAs from CABG patients, but there was no difference between groups: -43% +/- 29% vs -35% +/- 38% change after ERAH (n = 21) vs open harvest (n = 39; p = 0.342). Significantly more intimal injury was noted after ERAH vs open harvest (34/41 vs 9/43, intimal tears/total evaluated RAs, p < 0.0001). Most intimal injury was minor: only 2 tears involved the luminal surface of the RA (both after ERAH). Serial imaging in cadavers revealed that 86% of ostial tears occur in ERAH during the initial blunt dissection step using the endoscope. CONCLUSIONS: Although branch injury is a pitfall of ERAH, OCT imaging documented that the quality of RA procured is acceptable and comparable with open harvest. Catheter-based OCT provides an important quality assurance tool for RA harvest.


Subject(s)
Coronary Artery Bypass/methods , Coronary Disease/surgery , Radial Artery/transplantation , Tissue and Organ Harvesting/methods , Tomography, Optical Coherence/methods , Aged , Cadaver , Cohort Studies , Coronary Disease/diagnostic imaging , Coronary Disease/mortality , Endoscopy/methods , Evaluation Studies as Topic , Female , Humans , Male , Middle Aged , Observer Variation , Probability , Quality Control , Radial Artery/pathology , Radiography , Reproducibility of Results , Risk Assessment , Sensitivity and Specificity , Survival Analysis , Vascular Patency
18.
J Thorac Cardiovasc Surg ; 135(2): 367-75, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18242270

ABSTRACT

OBJECTIVES: Less-invasive options are available for surgical treatment of multivessel coronary artery disease. We hypothesized that stenting combined with grafting of the left anterior descending artery with the left internal thoracic artery through a minithoracotomy (hybrid procedure) would provide the best outcome. METHODS: Patients with equivalent numbers of coronary lesions (2.8 +/- 0.4) underwent either hybrid (n = 15) or off-pump coronary artery bypass through a sternotomy (n = 30). Early and 1-year outcomes were compared. Blood drawn from the aorta and coronary sinus immediately postoperatively was analyzed for activation of coagulation (prothrombin fragment 1.2 and activated Factor XII), myocardial injury (myoglobin), and inflammation (interleukin 8) by using an enzyme-linked immunosorbent assay. Target-vessel patency was determined by means of computed tomographic angiographic analysis. RESULTS: The hybrid procedure was associated with significantly shorter lengths of intubation and stays in the intensive care unit and hospital and perioperative morbidity (P < .05). Intraoperative costs were increased but postoperative costs were reduced for the hybrid procedure compared with off-pump coronary artery bypass through a sternotomy. As a result, overall total costs were not significantly different between the groups. After adjusting for potential confounders, assignment to the hybrid group was an independent predictor of shortened time to return to work (t = -2.12, P = .04). Patient satisfaction after the hybrid procedure, as judged on a 6-point scale, was greater versus that after off-pump coronary artery bypass through a sternotomy. Finally, the hybrid procedure showed significantly reduced transcardiac gradients of markers of coagulation, myocardial injury, and inflammation and a trend toward significant improvement in target-vessel patency. CONCLUSIONS: Perhaps because of reduced myocardial injury, inflammation, and activation of coagulation, patients undergoing the hybrid procedure had better perioperative outcomes and satisfaction, with excellent patency at 1 year's follow-up. These promising preliminary findings warrant further investigation of this procedure.


Subject(s)
Coronary Artery Bypass, Off-Pump/methods , Coronary Stenosis/mortality , Coronary Stenosis/surgery , Internal Mammary-Coronary Artery Anastomosis/methods , Aged , Analysis of Variance , Case-Control Studies , Cohort Studies , Coronary Angiography , Coronary Artery Bypass, Off-Pump/mortality , Coronary Stenosis/diagnostic imaging , Female , Follow-Up Studies , Humans , Internal Mammary-Coronary Artery Anastomosis/mortality , Length of Stay/trends , Logistic Models , Male , Middle Aged , Pain, Postoperative/physiopathology , Pilot Projects , Postoperative Complications/mortality , Probability , Risk Assessment , Sensitivity and Specificity , Severity of Illness Index , Time Factors , Tomography, X-Ray Computed , Treatment Outcome , Vascular Patency
19.
Eur J Cardiothorac Surg ; 33(2): 215-21, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18068996

ABSTRACT

OBJECTIVE: Accumulating evidence suggests that a hypercoagulable state influences early graft failure after off-pump coronary artery bypass (OPCAB). We hypothesized that regional myocardial ischemia caused by obligatory periods of coronary occlusion during OPCAB is an important trigger for this prothrombotic state. METHODS: Using a series of biomarkers, 60 consecutive patients undergoing OPCAB were monitored for myocardial injury (myoglobin), inflammation (TNF-alpha, IL-8) and thrombosis (thrombin generation-F1.2, contact activation pathway-FXII-a, platelet derived microparticles-via flow cytometry). The transcardiac gradients of these markers were determined by assaying both arterial and coronary sinus blood just after protamine administration. Intramyocardial pH was monitored continuously during coronary occlusion in a subset (N=30 grafts, 11 patients). The influence of management strategies affecting hemostasis (e.g. antiplatelet therapy, anti-fibrinolytics, peak activated clotting time (ACT) during heparinization) was analyzed. RESULTS: Ischemic injury, depicted by the transcardiac myoglobin gradient, significantly correlated with intramyocardial acidosis during coronary occlusion (R=0.96, p<0.0001) and predicted the transcardiac gradients of TNF-alpha (R=0.83, p<0.001) and F1.2 (R=0.72, p<0.0001). Transcardiac F1.2 strongly correlated with TNF-alpha (R=0.73, p=0.01) and IL-8 (R=0.51, p=0.02). Patients receiving aprotinin (N=20) showed significantly lower transcardiac gradients for myoglobin (4.1+/-7.5% vs 72.9+/-108.8% change, p=0.002), F1.2 (31+/-37% vs 89+/-149%, p=0.03), FXII-a (2.6+/-4.1% vs 19.2+/-34%, p=0.04) and microparticles (7+/-3.9% vs 12.9+/-8%, p=0.01). CONCLUSIONS: Strong correlations between myocardial ischemia and the transcardiac gradients of markers for inflammation and thrombosis suggest that even brief episodes of coronary occlusion in the beating heart may have pathophysiologic consequences. Aprotinin, but not other factors that influence the coagulation system, appears to mitigate this process during OPCAB.


Subject(s)
Coronary Artery Bypass, Off-Pump/methods , Graft Occlusion, Vascular/etiology , Myocarditis/etiology , Thrombophilia/etiology , Warm Ischemia/adverse effects , Acidosis/complications , Acidosis/epidemiology , Aged , Aprotinin/pharmacology , Aprotinin/therapeutic use , Female , Graft Occlusion, Vascular/blood , Humans , Intraoperative Care/methods , Male , Middle Aged , Myoglobin/blood , Myoglobin/drug effects , Platelet Activation/drug effects , Prospective Studies , Serine Proteinase Inhibitors/pharmacology , Serine Proteinase Inhibitors/therapeutic use , Thrombophilia/blood , Thrombophilia/prevention & control , Thrombosis/blood , Tumor Necrosis Factor-alpha/blood
20.
J Thorac Cardiovasc Surg ; 134(5): 1259-65, 2007 Nov.
Article in English | MEDLINE | ID: mdl-17976458

ABSTRACT

OBJECTIVE: Residual clot strands within the excised saphenous vein are an increasingly recognized sequela of endoscopic vein harvest. We hypothesized that endoscopic visualization facilitated by sealed carbon dioxide insufflation causes stagnation of blood within the saphenous vein. In the absence of prior heparin administration, this stasis provokes clot formation. METHODS: Forty consecutive patients having coronary artery bypass grafting underwent endoscopic vein harvest using sealed (Guidant VasoView, n = 30; Guidant Corp, Minneapolis, Minn) or open (Datascope ClearGlide, n = 10; Datascope Corp, Montvale, NJ) carbon dioxide insufflation followed by ex vivo assessment of intraluminal saphenous vein clot via optical coherence tomography. In the sealed carbon dioxide insufflation groups, clot formation was compared with (preheparinized, n = 20) and without (control, n = 10) heparin administration before endoscopic vein harvest, either at a fixed dose or titrated to an activated clotting time greater than 300 seconds. Risk factors for clot formation were assessed. RESULTS: Residual saphenous vein clot was a universal finding in control veins (sealed carbon dioxide insufflation endoscopic vein harvest without preheparinization). At either dose used, heparin given before endoscopic vein harvest significantly decreased saphenous vein clot burden. A similar reduction in clot was observed when using open carbon dioxide insufflation endoscopic vein harvest without preheparinization. Intraoperative blood loss and blood product requirements were similar in all groups. Patient age and preoperative maximum amplitude of the thrombelastography tracing showed a linear correlation with saphenous vein clot volume. CONCLUSION: By enabling the quantification of this issue as never before possible, optical coherence tomography screening revealed that intraluminal saphenous vein clot is frequently found after endoscopic vein harvest. Systemic heparinization before harvest or an open carbon dioxide endoscopic vein harvest system are benign changes in practice that can significantly lessen this complication.


Subject(s)
Anticoagulants/therapeutic use , Heparin/therapeutic use , Saphenous Vein/transplantation , Tissue and Organ Harvesting/adverse effects , Venous Thrombosis/prevention & control , Aged , Coronary Artery Bypass , Endoscopy/adverse effects , Female , Humans , Male , Middle Aged , Tissue and Organ Harvesting/instrumentation , Tomography, Optical Coherence , Venous Thrombosis/diagnosis , Venous Thrombosis/etiology
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