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1.
The value of phenformin and ethyloestrenol in the prevention of deep venous thrombosis in patients undergoing surgery.
Atkins, P; Brown, I K; Downie, R J; Haggart, B G; Littler, J; Robb, P M; Santer, G J; Jones, I.
Thromb Haemost ; 39(1): 89-96, 1978 Feb 28.
Article in English | MEDLINE | ID: mdl-580509

ABSTRACT

The effect of phenformin and ethyloestrenol on the incidence of post-operative deep venous thrombosis was studied in 314 surgical patients in a double-blind randomised trial. Although the laboratory tests suggested that the regime produced an increase in activators of the fibrinolytic system, the drugs used did not lower the incidence of post-operative deep venous thrombosis. Possible explanations of this paradox are advanced.


Subject(s)
Ethylestrenol/therapeutic use , Phenformin/therapeutic use , Thrombophlebitis/prevention & control , Thrombophlebitis/surgery , Fibrinolysis , Humans , Plasminogen/analysis , Postoperative Complications
2.
Letter: Diagnostic criteria in the 125i-fibrinogen test.
Atkins, P; Brown, I K; Santer, G J; Robb, P M.
Br Med J ; 4(5989): 163-4, 1975 Oct 18.
Article in English | MEDLINE | ID: mdl-1191980

Subject(s)
Fibrinogen , Humans , Thrombophlebitis/diagnosis
3.
Letter: Fibrinolytic activity and D.V.T.
Robb, P M; Santer, G J; Brown, I K.
Lancet ; 1(7855): 455, 1974 Mar 16.
Article in English | MEDLINE | ID: mdl-4131455

Subject(s)
Fibrinolysis/drug effects , Postoperative Complications/prevention & control , Thrombophlebitis/prevention & control , Ethylestrenol/pharmacology , Humans , Phenformin/pharmacology , Postoperative Care , Preoperative Care
4.
Regional lung function in scoliosis.
Littler, W A; Brown, I K; Roaf, R.
Thorax ; 27(4): 420-8, 1972 Jul.
Article in English | MEDLINE | ID: mdl-5075612

Subject(s)
Respiration , Scoliosis/physiopathology , Adolescent , Adult , Female , Humans , Lung/blood supply , Male , Posture , Radionuclide Imaging , Regional Blood Flow , Thoracic Vertebrae , Ventilation-Perfusion Ratio , Xenon
5.
[Effects of a combined therapy with ethylestrenol and phenformin on fibrinolysis of selected patients before, during and after surgery]. / Wirkung einer kombinierten Therapie mit Athylöstrenol und Phenformin auf die Fibrinolyse von ausgewählten Patienten vor, während und nach der Operation.
Brown, I K; Santer, G J.
Z Ernahrungswiss Suppl ; 12: Suppl 12:52-7, 1972.
Article in German | MEDLINE | ID: mdl-4505206

Subject(s)
Ethylestrenol/pharmacology , Fibrinolysis/drug effects , Phenformin/pharmacology , Postoperative Complications/prevention & control , Fibrinogen/analysis , Humans , Postoperative Care , Preoperative Care , Surgical Procedures, Operative , Time Factors
6.
Pharmacological stimulation of fibrinolytic activity in the surgical patient.
Brown, I K; Haggart, B; Murray, G H; Downie, R J; Littler, J; Robb, P M; Santer, G J.
Lancet ; 1(7703): 774-6, 1971 Apr 17.
Article in English | MEDLINE | ID: mdl-4101274

Subject(s)
Ethylestrenol/pharmacology , Fibrinolysis/drug effects , Phenformin/pharmacology , Surgical Procedures, Operative , Blood Coagulation Tests , Blood Glucose/analysis , Clinical Trials as Topic , Ethylestrenol/therapeutic use , Female , Fibrinogen/analysis , Fibrinolytic Agents/therapeutic use , Humans , Male , Phenformin/therapeutic use , Postoperative Care , Postoperative Complications/prevention & control , Preoperative Care , Stimulation, Chemical , Thrombophlebitis/prevention & control
7.
Lung scanning using xenon.
Brown, I K; Seaton, A; Gaziano, D.
Thorax ; 24(3): 381, 1969 May.
Article in English | MEDLINE | ID: mdl-5810391

Subject(s)
Radionuclide Imaging , Respiratory Tract Diseases/diagnosis , Xenon , Humans , Mitral Valve Insufficiency/diagnosis
8.
Electrocardiography amd vectorcardiography in right ventricular hypertrophy from chronic bronchitis.
Brown, I K.
Br Heart J ; 30(4): 470-4, 1968 Jul.
Article in English | MEDLINE | ID: mdl-4232289

Subject(s)
Bronchitis/physiopathology , Cardiomegaly/physiopathology , Bronchitis/complications , Cardiomegaly/etiology , Chronic Disease , Electrocardiography , Heart Block/pathology , Heart Ventricles/pathology , Heart Ventricles/physiopathology , Humans , Male , Middle Aged , Vectorcardiography
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