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1.
Dalton Trans ; 46(42): 14612-14630, 2017 Oct 31.
Article in English | MEDLINE | ID: mdl-28703233

ABSTRACT

Copper(ii) bis(thiosemicarbazone) derivatives have been used extensively in positron emission tomography (PET) to image hypoxia and blood flow and to radiolabel cells for cell tracking. These applications depend on control of redox potentials and lipophilicity of the bis(thiosemicarbazone) complexes, which can be adjusted by altering peripheral ligand substituents. This paper reports the synthesis of a library of new dissymmetrically substituted bis(thiosemicarbazone) ligands by controlling the condensation reactions between dicarbonyl compounds and 4-substituted-3-thiosemicarbazides or using acetal protection. Copper complexes of the new ligands have been prepared by reaction with copper acetate or via transmetallation of the corresponding zinc complexes, which are convenient precursors for the rapid synthesis of radio-copper complexes. Well-defined structure-activity relationships linking ligand alkylation patterns with redox potential and lipophilicity of the complexes are reported.


Subject(s)
Coordination Complexes/chemistry , Copper/chemistry , Hydrophobic and Hydrophilic Interactions , Positron-Emission Tomography/methods , Radiopharmaceuticals/chemistry , Thiosemicarbazones/chemistry , Alkylation , Coordination Complexes/chemical synthesis , Electrochemistry , Ketones/chemistry , Ligands , Oxidation-Reduction , Radiopharmaceuticals/chemical synthesis
2.
Acta Crystallogr E Crystallogr Commun ; 71(Pt 11): 1349-51, 2015 Nov 01.
Article in English | MEDLINE | ID: mdl-26594508

ABSTRACT

In the structure of the title complex, [Zn(C8H14N6S2)(C5H5N)], the Zn(II) ion has a pseudo-square-pyramidal coordination environment and is displaced by 0.490 Šfrom the plane of best fit defined by the bis-(thio-semicarbazonate) N2S2 donor atoms. Chains sustained by intermolecular N-H⋯N and N-H⋯S hydrogen-bonding interactions extend parallel to [10-1].

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