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1.
Eplasty ; 102010 Sep 01.
Article in English | MEDLINE | ID: mdl-20827301

ABSTRACT

In the aftermath of a mass disaster, standard care methods for treatment of burn injury will often not be available for all victims. A method of fluid resuscitation for burns that has largely been forgotten by contemporary burn experts is enteral resuscitation. We identified 12 studies with over 700 patients treated with enteral resuscitation, defined as drinking or gastric infusion of salt solutions, from the literature. These studies suggest that enteral resuscitation can be an effective treatment for burn shock under conditions in which the standard IV therapy is unavailable or delayed, such as in mass disasters and combat casualties. Enteral resuscitation of burn shock was effective in patients with moderate (10-40% TBSA) and in some patients with more severe injuries. The data suggests that some hypovolemic burn and trauma patients can be treated exclusively with enteral resuscitation, and others might benefit from enteral resuscitation as an initial alternative and a supplement to IV therapy. A complication of enteral resuscitation was vomiting, which occurred less in children and much less when therapy was initiated within the first postburn hour. Enteral resuscitation is contra-indicated when the patient is in "peripheral circulatory collapse". The optimal enteral solution and regimen has not yet been defined, nor has its efficacy been tested against modern IV resuscitation. The oldest studies used glucose-free solutions of buffered isotonic and hypotonic saline. Studies that are more recent show benefit of adding glucose to electrolyte solutions similar to those used in the treatment of cholera. If IV therapy for mass casualty care is delayed due to logistical constraints, enteral resuscitation should be considered.

2.
J Immunol ; 176(10): 5730-4, 2006 May 15.
Article in English | MEDLINE | ID: mdl-16670277

ABSTRACT

Recent data from murine models have confirmed that Langerhans cells are not the only population of APCs in the skin involved in initiating immune responses. In healthy human skin, we identify CD1a(+) dermal APCs located close to the lymphatic vessels in the upper layers of the dermis that are unequivocally distinct from migrating Langerhans cells but exhibit both potent allostimulatory capacity and a chemotactic response to CCR7 ligands. In contrast, CD14(+) dermal APCs are distributed throughout the dermis and lack a chemotactic response to CCR7 ligands. CD1a(+) dermal APCs therefore represent an APC population distinct from Langerhans cells that are capable of migrating to lymph nodes and stimulating naive T cells. In humans, CD1a(+) dermal APCs may fulfill some of the roles previously ascribed to Langerhans cells.


Subject(s)
Antigen-Presenting Cells/metabolism , Antigens, CD1/biosynthesis , Dermis/cytology , Dermis/immunology , Receptors, Chemokine/physiology , Antigen Presentation , Antigen-Presenting Cells/immunology , Cells, Cultured , Dermis/metabolism , Flow Cytometry , Humans , Ligands , Receptors, CCR7 , Receptors, Chemokine/metabolism
3.
Burns ; 31(6): 692-5, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16129223

ABSTRACT

This study was designed to examine functional and psychological outcome of severely burned patients adults. Adult patients (n=38) admitted to the Royal Brisbane hospital with burns >40% TBSA were assessed two years post injury using the Abbreviated BSHS and a supplemental questionnaire relating to specific physiotherapy and occupational health issues. An average return to driving occurred at 36 weeks and return to work at 51 weeks. Involvement of the hands and face significantly altered the physical domain of the questionnaire and the sub-domain examining role. Genital burns altered the sexual sub-domain, but this was not gender dependant. Mobility and self care were significantly altered when a burn was >20% TBSA full thickness. The study demonstrates that these patients can develop functional independence and good quality of life. The long term outlook for patients with large burns is generally positive. Consequently, burn care professionals can be reassured that the effort is worthwhile.


Subject(s)
Burns/rehabilitation , Quality of Life , Adolescent , Adult , Aged , Automobile Driving , Body Image , Burns/psychology , Employment , Female , Health Status Indicators , Humans , Interpersonal Relations , Male , Middle Aged , Recovery of Function
4.
Burns ; 31(4): 439-44, 2005 Jun.
Article in English | MEDLINE | ID: mdl-15896505

ABSTRACT

High voltage electrical injuries in children are rare. They produce severe internal damage to limbs resulting in a high incidence of amputation. Early, aggressive serial debridement ensures adequate removal of dead tissue. Flap coverage to defects is necessary. Secondary surgery is common, and delayed sequelae such as tendon rupture should be expected.


Subject(s)
Burns, Electric/surgery , Forearm Injuries/surgery , Hand Injuries/surgery , Leg Injuries/surgery , Tendon Injuries/surgery , Abdomen , Adolescent , Amputation, Surgical , Child , Debridement , Female , Humans , Male , Reoperation , Skin Transplantation/methods , Thigh , Transplantation, Autologous , Transplantation, Homologous
5.
Mil Med ; 170(11): 919-20, 2005 Nov.
Article in English | MEDLINE | ID: mdl-16450817

ABSTRACT

Special Forces are at risk of serious burn injury. We have suggested standard operating procedures for burn injury management in a constrained environment, with novel uses of operational kit components for trauma care. In addition, we propose instruction in basic skills of escharotomy for forward troops.


Subject(s)
Brain Injuries/therapy , Military Personnel , Warfare , Humans , Military Medicine , United States
8.
Burns ; 30(6): 577-80, 2004 Sep.
Article in English | MEDLINE | ID: mdl-15302425

ABSTRACT

There is a world shortage of burn surgeons. A questionnaire survey of all plastic surgical trainees in Australasia was conducted at a recent training event. 10/48 trainees would consider burns as a major subspecialty interest. A good experience of burn care whilst training seems to be important in influencing trainees consider it as a career choice. The perception of a career as a burn surgeon is poor, and requires some urgent attention.


Subject(s)
Burns/surgery , Surgery, Plastic/education , Attitude of Health Personnel , Australasia , Career Choice , Education, Medical, Graduate , Humans , Motivation , Surveys and Questionnaires , Workforce
9.
Br J Plast Surg ; 57(5): 446-9, 2004 Jul.
Article in English | MEDLINE | ID: mdl-15191826

ABSTRACT

Day surgery is an increasing element of surgical practice, particularly in plastic surgery. A large proportion of work is undertaken using local anaesthesia in the elderly who have associated co-morbidity. At present no national guidelines exist for the use of local anaesthesia in day surgery. This study aimed to examine the relationship between patient selection and complications, in order to identify those who should be excluded from local anaesthetic day surgery treatment. A retrospective analysis of patients undergoing local anaesthetic plastic surgical procedures over a 10-month period identified 328 operative episodes. There were 37 complications, two of which required admission 5 days post surgery for treatment of wound infection. The remaining complications were treated on an outpatient basis. An increased level of complication was seen in males with elevated systolic blood pressure and with the use of full thickness skin grafts in reconstruction. Age, smoking, ASA grade, and medication that altered coagulation (aspirin, warfarin and steroids) were not associated with increased complication levels. We conclude that local anaesthetic plastic surgical procedures are associated with a very low level of risk, and are suitable for those patients traditionally regarded as unsuitable for general anaesthetic day surgery.


Subject(s)
Ambulatory Surgical Procedures/statistics & numerical data , Anesthesia, Local/statistics & numerical data , Patient Selection , Adolescent , Adult , Aged , Aged, 80 and over , Ambulatory Surgical Procedures/adverse effects , Analysis of Variance , Anesthesia, Local/adverse effects , Female , Humans , Male , Middle Aged , Regression Analysis , Retrospective Studies
10.
Injury ; 35(7): 697-707, 2004 Jul.
Article in English | MEDLINE | ID: mdl-15203310

ABSTRACT

Burn injury differs from other types of trauma in the apparent lack of urgency for treatment. We argue that in order to limit physiological damage and the development of multi-organ failure, management of the burn wound must be immediate and aggressive. Supportive fluid treatment should be judicious in order to prevent excessive oedema causing wound extension. Some potential strategies utilising oral fluid resuscitation are discussed, and potential pharmacological interventions. When associated with other trauma, major burn injury has a detrimental effect on morbidity and mortality, and surgical management of both aspects of a patient's injuries are altered.


Subject(s)
Burns/therapy , Emergency Treatment/methods , Burns/prevention & control , Critical Care/methods , Humans , Multiple Organ Failure/prevention & control , Resuscitation , Shock, Traumatic/therapy
11.
Burns ; 30(4): 303, 2004 Jun.
Article in English | MEDLINE | ID: mdl-15145185
12.
Burns ; 30(3): 259-61, 2004 May.
Article in English | MEDLINE | ID: mdl-15082355

ABSTRACT

One of the problems with the dermal substitute Integra has been securing the material to the wound bed to prevent shearing and loss. Techniques to achieve stability include staples and elastic netting with an over layer of absorbent dressings that can be changed regularly. We report an effective technique using suction dressings to immobilise Integra. This technique led to firm application underlying tissue, and appeared to decrease fluid collection under the Integra. Earlier mobilisation and discharge from hospital were facilitated.


Subject(s)
Bandages , Biocompatible Materials , Burns/therapy , Child , Chondroitin Sulfates , Collagen , Humans , Length of Stay , Prospective Studies , Suction
16.
Burns ; 30(1): 82-5, 2004 Feb.
Article in English | MEDLINE | ID: mdl-14693091

ABSTRACT

CONTEXT: Concern engendered by a previous study that showed inadequate first aid for burn injuries was prevalent in the community led to a novel multi-media public health campaign ensued to address the issue. OBJECTIVE: To determine whether this public health campaign influenced behaviour by altering first aid treatment for burn injuries (BFAT). DESIGN, SETTING AND POPULATION: Prospective intervention study. Consecutive patients with acute burn injuries over two 4-month intervals, presenting to a regional burn service, Auckland, New Zealand. This research was ethically approved by the Local Research Ethics Committee. MAIN OUTCOME MEASURES: Demographics, burn size, adequacy of burn first aid, outpatient/inpatient wound care and operative intervention requirement. RESULTS: Adequacy of BFAT improved following the campaign (59% versus 40%, P=0.004). Fewer inpatient admissions (64.4% versus 35.8%, P<0.001) and surgical procedures (25.6% versus 11.4%, P<0.001) were undertaken following the campaign with a corresponding increase in outpatient care. Greatest decreases were observed in Maori and Pacific Islanders, and in children <10 years old. CONCLUSIONS: Adequacy of BFAT together with a reduction in the numbers of patients requiring inpatient surgical care was improved by a multi-media public awareness campaign.


Subject(s)
Burns/therapy , First Aid/standards , Health Promotion/methods , Hospitalization/statistics & numerical data , Adolescent , Adult , Aged , Burns/ethnology , Burns/psychology , Child , Child, Preschool , Communications Media , Female , Health Behavior , Health Knowledge, Attitudes, Practice , Humans , Infant , Male , Middle Aged , New Zealand/epidemiology , Program Evaluation , Prospective Studies
17.
Burns ; 29(8): 834-6, 2003 Dec.
Article in English | MEDLINE | ID: mdl-14636760

ABSTRACT

Inhibition of wound contraction by topical anti microbial agents has been described. The purpose of this study was to further investigate that phenomenon and to explore the effect that other agents such as Aloe vera might have on this process. Full-thickness excised wounds were created on the dorsum of Sprague-Dawley rats under anaesthesia. The wounds were treated with topical agents three times daily for fourteen days, then observed until healed. Groups were: saline control, placebo (aqueous cream) control, silver sulphadiazine (SSD) cream 1%, SSD 0.5%, SSD 1% with Aloe vera, SSD 1% with nystatin, nystatin. Wound surface areas were measured each three days. Time to 50% and 90% healing was compared using ANOVA. Wound half-life and healing times were shortest in the SSD/Aloe vera and nystatin groups (P<0.05) and longest in the 1% SSD and saline control groups. The placebo group (aqueous cream) healed in a significantly shorter time (P<0.05) than the control (saline) group. Wound contraction was delayed by saline and SSD. Nystatin and Aloe vera, when added to SSD, reversed that effect. These data suggest that a dry wound (saline) heals slowly. Infection control without delay of wound healing is most appealing and clinical trials are planned.


Subject(s)
Aloe , Anti-Bacterial Agents/therapeutic use , Burns/therapy , Phytotherapy , Silver Sulfadiazine/therapeutic use , Wound Healing , Administration, Topical , Animals , Antifungal Agents/therapeutic use , Combined Modality Therapy , Male , Models, Animal , Nystatin/therapeutic use , Ointments , Rats , Rats, Sprague-Dawley , Silver Sulfadiazine/adverse effects , Sodium Chloride/administration & dosage , Treatment Outcome , Wound Healing/drug effects
18.
Burns ; 29(3): 197-8, 2003 May.
Article in English | MEDLINE | ID: mdl-12706610
19.
Burns ; 29(2): 159-62, 2003 Mar.
Article in English | MEDLINE | ID: mdl-12615463

ABSTRACT

When faced with large numbers of burn patients and limited resources such as in war or disaster, oral fluids may be used as an alternative to intravenous resuscitation. Vomiting during the first 48 h can limit the usefulness of this method; yet its incidence has not been documented. This study aimed to identify those patients at risk of vomiting following burn injury and who therefore might be suitable for oral resuscitation. A retrospective review of case notes from burn patients between 1990 and 2001 was undertaken. Burns requiring intravenous resuscitation (>10% total body surface area (TBSA) in children, >15% TBSA in adults) were included (n=110). Documentation of vomiting during the first 48 h following burn injury to an extent that prevented commencement of feeding was regarded as significant. Patients that vomited were significantly older (28.3 years compared with 18.5 years, P=0.03), and had sustained significantly larger burns (29.8% compared with 22.9%, P=0.047). Administration of opiates and anti-emetics was similar in both groups and not significant. Although the number of patients in this study excludes a logistic regression analysis, it would seem reasonable to attempt oral resuscitation in patients under 25 years of age and with burns up to 25% TBSA given limited resources.


Subject(s)
Burns/complications , Fluid Therapy/methods , Vomiting/etiology , Adolescent , Adult , Aged , Aged, 80 and over , Body Surface Area , Burns/therapy , Child , Disasters , Drinking , Emergency Medicine/methods , Female , Humans , Male , Middle Aged , Retrospective Studies , Risk Factors , Vomiting/therapy
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