ABSTRACT
Elevating the temperature of cancerous cells is known to increase their susceptibility to subsequent radiation or chemotherapy treatments, and in the case in which a tumor exists as a well-defined region, higher intensity heat sources may be used to ablate the tissue. These facts are the basis for hyperthermia based cancer treatments. Of the many available modalities for delivering the heat source, the application of a laser heat source under the guidance of real-time treatment data has the potential to provide unprecedented control over the outcome of the treatment process [7, 18]. The goals of this work are to provide a precise mathematical framework for the real-time finite element solution of the problems of calibration, optimal heat source control, and goal-oriented error estimation applied to the equations of bioheat transfer and demonstrate that current finite element technology, parallel computer architecture, data transfer infrastructure, and thermal imaging modalities are capable of inducing a precise computer controlled temperature field within the biological domain.
ABSTRACT
PIP: A microsurgical technique for autograft transplantation of the rabbit oviduct with anastomosis of the tubal artery and vein is described. 4 virgin female New Zealand white rabbits were used. 1 rabbit delivered a live litter of 9, 33 days following mating. A 2nd rabbit is pregnant. A third rabbit died 36 hours postoperatively due to prolonged anesthesia. The graft proceeded uneventfully in the 4th rabbit, but the uterine cornu became infarcted because the uterine artery was ligated too far from its anastomosis with the tubal artery. An advantage of a microsurgical technique for tubal and vascular anastomosis is that only the tube needs to be grafted, with minimal disturbance of the surrounding tissues. In that healthy human fallopian tubes are readily available, it appears that this technique could be developed for homograft transplantation in patients with extensive oviduct disease.^ieng
