1.
Dev Biol Stand
; 59: 51-62, 1985.
Article
in English
| MEDLINE
| ID: mdl-2408946
ABSTRACT
Single amino acid substitutions, introduced by genetic engineering, significantly modify the behavior of the B-subunits of the cholera/coli enterotoxin family in SDS-PAGE and also markedly affect the reactivity of the proteins with mouse hybridoma-derived monoclonal antibodies raised against H-LT. The results indicate that single amino acids play an important role in defining epitopes in these proteins.