Prophylactic ondansetron does not prevent shivering or decrease shivering severity during cesarean delivery under combined spinal epidural anesthesia: a randomized trial.

OBJECTIVES: Cesarean delivery is commonly performed under regional anesthesia, which is often associated with maternal shivering. This can cause distress and interfere with monitoring. The study objective was to evaluate the antishivering efficacy of ondansetron, which reduces the incidence and severity of shivering in nonobstetric patients. We hypothesized that there would be a significant decrease in the incidence and/or severity of shivering in women who are given intravenous ondansetron 8 mg before combined spinal epidural (CSE) anesthesia, when compared with placebo. METHODS: This was a randomized, double-blinded, parallel-group, placebo-controlled trial of 118 women scheduled for elective cesarean surgery. Women received either intravenous ondansetron 8 mg (n = 58) or saline (n = 60) before CSE anesthesia (intrathecal hyperbaric bupivacaine 0.5% 2.2-2.5 mL plus fentanyl 15 µg). The incidence and severity of shivering, measured on a validated 5-point scale, and other outcomes, such as nausea, pruritus, headache, or satisfaction, were assessed at 3 time points during the surgery and postoperative period. RESULTS: The incidence of shivering at any time point did not differ significantly between groups: ondansetron 41% versus placebo 47% (P = 0.54). The incidence of severe shivering at any time was not significantly different: ondansetron 32% versus placebo 33% (P = 0.79). There were no significant differences between the groups for any secondary outcomes. CONCLUSIONS: Intravenous ondansetron 8 mg before performing CSE anesthesia in women undergoing elective cesarean delivery does not decrease the incidence or severity of shivering.

Preoperative anaemia is common in patients undergoing major gynaecological surgery and is associated with a fivefold increased risk of transfusion.

AIMS: To ascertain the incidence of preoperative anaemia in a cohort of patients undergoing major gynaecological surgery in a tertiary Australian hospital over a two-year period and to investigate whether it is associated with an increased rate of transfusion or complications. METHODS: Using the Western Australian Patient Blood Management (PBM) Data System, we obtained data for 843 women undergoing major gynaecological surgery over a two-year period at King Edward Memorial Hospital, Subiaco, Western Australia. We used regression analysis to investigate the relationship between preoperative anaemia, red cell transfusion, length of hospital stay and complications. RESULTS: Preoperative anaemia was present in 18.1% of women and was associated with a significantly increased risk of receiving a red cell transfusion (OR = 5.74, P < 0.001). After adjusting for confounders, preoperative anaemia was not independently associated with increased complications or hospital length of stay, but receiving a red cell transfusion was (P < 0.001). CONCLUSION: This study demonstrates preoperative anaemia is common in women undergoing elective major gynaecological surgery and is associated with increased red cell transfusions. A system to detect and treat anaemia prior to surgery in these patients should be implemented, and interventions should be evaluated to ensure they are effective.

Effect of hyperhomocysteinemia induced by methionine administration on flow-mediated dilatation of the brachial artery in healthy subjects.

Homocysteine may contribute to systolic hypertension and cardiac events by decreasing conduit artery compliance and inducing endothelial dysfunction. The effects of the experimental induction of hyperhomocysteinemia on systemic arterial compliance and pulsewave velocity are unclear, with contradictory results from previous studies. The investigators tested whether oral methionine impairs brachial artery compliance in addition to endothelial function.