ABSTRACT
The Authors, starting with the hypothesis that could exist a correlation between the opiate withdrawal and the migraine crisis, used the naloxone, opiate pure antagonist, in order to induced the migraine crisis. 30 patients affected by migraine were studied; naloxone was administered acutely (2 mg e.v.) during the asintomatic period. The naloxone administration never caused the migraine crisis. The patients didn't complain variations regarding the psycho-physical status or the monitored clinical parameters.
Subject(s)
Migraine Disorders/chemically induced , Naloxone , Substance Withdrawal Syndrome , Adolescent , Adult , Female , Humans , Male , Middle Aged , Migraine Disorders/etiology , NarcoticsABSTRACT
The authors evaluated the efficacy of a DHE methanesulphonate for migraine attacks and its tolerability on liver, gallbladder and cardiovascular system functions. Twenty-eight patients affected by migraine were studied. They were withdrawn from preventive therapy for at least one month and treated for three months. The drug showed a good efficacy with a statistical significant reduction of severity and duration of attacks. No variation of the biochemical and morphological parameters of liver, gallbladder and cardiovascular function were found throughout the treatment.
Subject(s)
Dihydroergotamine/analogs & derivatives , Migraine Disorders/prevention & control , Adolescent , Adult , Delayed-Action Preparations , Dihydroergotamine/pharmacology , Dihydroergotamine/therapeutic use , Drug Tolerance , Female , Humans , Male , Middle Aged , Migraine Disorders/drug therapySubject(s)
Clonidine/therapeutic use , Migraine Disorders/drug therapy , Adolescent , Adult , Clinical Trials as Topic , Drug Evaluation , Female , Humans , Male , Middle AgedABSTRACT
Two cases of non-familial hemiplegic migraine are described. Naloxone reversed the neurological deficits accompanying attacks, whereas the pain was uninfluenced. The possibility that the opiate-antagonist naloxone facilitates regression of neurological symptoms associated with migraine attacks in general is voiced.