ABSTRACT
OBJECTIVE: To determine health and disabilities of preterm infants at age 10. DESIGN: Prospective follow-up study. SETTING: TNO Preventive en Gezondheid, sector Jeugd. Leiden, the Netherlands. METHOD: A questionnaire on medical consumption and physical disabilities was sent to the parents of a Dutch cohort of infants born alive in 1983 with a gestational age < 32 weeks and (or) a birth weight < 1500 g. The data were compared with outcomes at 5 years of age and with a peer group in mainstream education (data collected in a representative sample from the school health care system). RESULTS: Questionnaires on 75% of the eligible children were returned. Almost 40% of the preterm children had been admitted to hospital after the age of 5. Children in special education were significantly more often treated by a physiotherapist and (or) speech therapist. Overall 45% of the children suffered from a physical disability. This was six times as frequent as in a peer group from the school health survey. Although the assessment of physical disabilities was based on a paediatric examination at age 5 and on a parental questionnaire at age 10, differences were small. CONCLUSION: Mild developmental problems and learning disabilities are frequent in preterm infants. Research of preventive methods and timely interventions are needed and should be incorporated in the facilities for neonatal intensive care.
Subject(s)
Child Development , Disabled Children , Health Services/statistics & numerical data , Infant, Premature , Child , Child, Preschool , Cohort Studies , Developmental Disabilities/etiology , Humans , Infant, Low Birth Weight , Infant, Newborn , Learning Disabilities/etiology , Prospective StudiesABSTRACT
The authors adopt an interdependence analysis of social value orientation, proposing that prosocial, individualistic, and competitive orientations are (a) partially rooted in different patterns of social interaction as experienced during the periods spanning early childhood to young adulthood and (b) further shaped by different patterns of social interaction as experienced during early adulthood, middle adulthood, and old age. Congruent with this analysis, results revealed that relative to individualists and competitors, prosocial individuals exhibited greater levels of secure attachment (Studies 1 and 2) and reported having more siblings, especially sisters (Study 3). Finally, the prevalence of prosocials increased--and the prevalence of individualists and competitors decreased--from early adulthood to middle adulthood and old age (Study 4).
Subject(s)
Human Development , Interpersonal Relations , Object Attachment , Social Behavior , Social Values , Adolescent , Adult , Aged , Aged, 80 and over , Analysis of Variance , Competitive Behavior , Cooperative Behavior , Family Characteristics , Female , Humans , Male , Middle Aged , Multivariate Analysis , Netherlands , Psychological TheoryABSTRACT
Vinylogous hydroxamic acids (3-(N-hydroxy-N-alkylamino)-2-propen-1-ones, VHA) were prepared as antiinflammatory agents. The synthesis, chemical properties, and in vitro biological activities of these relatively unexplored compounds are described. The VHAs were prepared by condensation of the appropriate N-substituted hydroxylamine with any of the three reagents: a 1,3-dicarbonyl compound (method A); a vinylogous amide (method B); or an alkynone (method C). The VHAs exist as one or more tautomers in solution with the relative proportions of each being dependent upon the structure of the VHA, solvent, and pH. VHAs undergo some of the typical reactions of hydroxamic acids as well as those of vinylogous amides. VHAs are active as inhibitors of 5-lipoxygenase and of IL-1 biosynthesis in vitro, which do not inhibit other enzymes of the arachidonic acid cascade. They have been shown by ESR studies to bring about inhibition of soybean type 1 15-lipoxygenase by reduction of the active site iron.
Subject(s)
Hydroxamic Acids/chemical synthesis , Interleukin-1/biosynthesis , Lipoxygenase Inhibitors/chemical synthesis , Vinyl Compounds/chemical synthesis , Animals , Humans , Hydroxamic Acids/chemistry , Hydroxamic Acids/pharmacology , In Vitro Techniques , Lipoxygenase Inhibitors/chemistry , Lipoxygenase Inhibitors/pharmacology , Rats , Glycine max , Structure-Activity Relationship , Tumor Cells, Cultured , Vinyl Compounds/chemistry , Vinyl Compounds/pharmacologyABSTRACT
The possible utility of DuP 654, a potent 5-lipoxygenase inhibitor, for treating human inflammatory skin disease was investigated in murine skin treated with 1.0 mg arachidonic acid (AA). When DuP 654 was applied to murine skin treated with AA, it inhibited the resulting inflammation and influx of cells. High performance liquid chromatography and radioimmunoassay analysis of lipid extracts from AA-treated ears indicated that the influx of polymorphonuclear leukocytes (PMN) was temporally preceded by an appearance of significant amounts of 5-HETE (6.7 +/- 1.4 ng/ear) and Leukotriene B4 LTB4 0.92 +/- 0.2 ng/ear) when compared with extracts of untreated ears (5-HETE, 02 +/- 0.3 ng/ear; LTB4, less than 0.1 ng/ear). The levels of the 5-lipoxygenase products were reduced by treatment with 10 micrograms/ear DUP 654. Lipid extracts from AA-treated ears contain chemotactic activity for human PMN and this chemotactic activity in the AA-treated ears could be reduced but not eliminated by immunosorption with anti-LTB4 antibodies coupled to protein A-agarose. The appearance of the chemotactic activity was inhibited by DuP 654. Taken together, these data suggest that DuP 654 may have utility in human inflammatory skin disease.
