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Article in Es | IBECS | ID: ibc-63749

ABSTRACT

La nefritis intersticial aguda es una importante causa de fallo renal agudo reversible (1-3% de éstos). En la mayoría de las ocasiones está causada por fármacos, siendo los antiinflamatorios, las penicilinas y las sulfonamidas los más frecuentemente implicados en la actualidad. Las manifestaciones clínicas de la nefritis intersticial aguda han variado con el paso del tiempo y con el uso masivo de nuevos fármacos. El omeprazol es un inhibidor de la bomba de protones prescrito ampliamente para el tratamiento del reflujo gastroesofágico y de la úlcera péptica. Aunque el omeprazol es generalmente bien tolerado, puede producir efectos adversos importantes como fallo renal agudo por nefritis intersticial. A continuación presentamos el caso de un paciente que presenta nefritis intersticial aguda secundaria a la toma de omeprazol


Acute interstitial nephritis is an important cause of acute, reversible renal failure (1%-3% of these). Most of them are due to drugs, the most frequently involved at present being anti-inflammatory drugs penicillins and sulfonamides. The clinical manifestations of acute interstitial nephritis have varied over time and with the massive use of new drugs. Omeprazole is a proton pump inhibitor that has been widely described for the treatment of gastroesophageal reflux and peptic ulcer. Although omeprazole is generally well tolerated, it may produce serious side effects such as acute renal failure due to interstitial nephritis. In the following, we present the case of a patient who had acute interstitial nephritis secondary to taking omeprazole


Subject(s)
Humans , Male , Aged , Nephritis, Interstitial/chemically induced , Omeprazole/adverse effects , Acute Kidney Injury/etiology , Nephritis, Interstitial/complications
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