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1.
Acta Neurol Scand Suppl ; 188: 72-6, 2008.
Article in English | MEDLINE | ID: mdl-18439226

ABSTRACT

BACKGROUND: Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments in animal models for the disease, although MS is a disease only affecting humans. The cuprizone model is a model for toxic demyelination. In this model, young mice are fed with the copper chelator cuprizone, leading to oligodendrocyte death and a subsequent reversible demyelination. Spontaneous remyelination can be seen as early as 4 days after withdrawal of cuprizone. MATERIALS AND METHODS: This article reviews previous research on this model and discusses the potential of the model for future application in MS research. DISCUSSION: The cuprizone model correlates with newer histopathological data in MS and is a valuable tool for studies on de- and remyelination. The use of the C57BL/6 strain offers the potential for future studies on transgene and knockout mice.


Subject(s)
Chelating Agents , Cuprizone , Disease Models, Animal , Multiple Sclerosis/chemically induced , Multiple Sclerosis/pathology , Animals , Mice , Myelin Sheath/drug effects
2.
Scand J Gastroenterol ; 39(11): 1088-94, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15545167

ABSTRACT

BACKGROUND: Rheumatic joint pain is a common extra-intestinal complication of inflammatory bowel disease (IBD). Because the high ratio of n-6 to n-3 fatty acids (FAs) of the Western diet might promote rheumatic disorders, we sought to compare the effects of short-term duodenal administration of n-3-rich seal oil and n-6-rich soy oil on IBD-related joint pain. METHODS: Nineteen patients with IBD-related joint pain were included in the study; 9 had Crohn disease and 10 had ulcerative colitis. Ten millilitres seal oil (n = 10) or soy oil (n = 9) was self-administered through a nasoduodenal feeding tube 3 times daily for 10 days. RESULTS: Compared with soy oil treatment, seal oil significantly reduced the duration of morning stiffness (P = 0.024), number of tender joints (P = 0.035), intensity of pain (P = 0.025) and the doctor's scoring of rheumatic disease activity (P = 0.025) at the end of the 10-day treatment period. Analysis of the effects as area under the curve (area between the curve and baseline, zero) for the entire period from start of treatment until 6 months' post-treatment suggested a long-lasting beneficial effect of seal oil administration on joint pain, whereas soy oil tended (not significantly) to aggravate the condition. Consistently, the serum ratios of n-6 to n-3 FAs (P < 0.01) and arachidonic acid to eicosapentaenoic acid (P < 0.01) were reduced after treatment with seal oil. CONCLUSION: The results suggest distinctive, differential prolonged effects on IBD-related joint pain of short-term duodenal administration of n-3-rich seal oil (significant improvement) and n-6-rich soy oil (tendency to exacerbation).


Subject(s)
Arthralgia/therapy , Fatty Acids, Omega-3/administration & dosage , Inflammatory Bowel Diseases/complications , Soybean Oil/administration & dosage , Adolescent , Adult , Animals , Arthralgia/blood , Arthralgia/etiology , Duodenum , Fatty Acids/blood , Fatty Acids, Omega-6/administration & dosage , Female , Fur Seals , Humans , Inflammatory Bowel Diseases/blood , Intubation, Gastrointestinal , Male , Middle Aged
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