ABSTRACT
Point estimates can be generated by simple immunoassays when combined with a sequential statistical procedure. The method is called an extended simple immunoassay. A simple immunoassay for alpha-fetoprotein (counterimmunoelectrophoresis) was used to test the hypothesis that simple immunoassays are not restricted to qualitative "yet" or "no" results, but can provide quantitative results similar to radioimmunoassay. Potential benefits of this finding are discussed.
Subject(s)
Immunoassay/methods , Counterimmunoelectrophoresis/methods , Female , Humans , Radioimmunoassay/methods , Statistics as Topic , alpha-Fetoproteins/analysisABSTRACT
We have previously reported that myelin basic protein appears in CSF during acute attacks of multiple sclerosis. These studies have been extended to over 700 patients, 91 with multiple sclerosis. The data continues to indicate that myelin basic protein is released into cerebrospinal fluid during acute attacks of multiple sclerosis. We are currently characterizing the basic protein in the CSF.