Compromises of integration, specificity and emotional content of self-defining memories in patients with opioid-use disorder.

Autobiographical memory plays a major role in the construction of identity. A particular type of memory has been described as more relevant in pursuit of personal goals: self-defining memory (SDM). In patients with opioid-use disorder (OUD), SDM recall has not yet been investigated despite deficits in the retrieval of autobiographical memories. This study aims to characterise SDM recall in OUD patients. Patients (N = 25) and non-dependent individuals (N = 25) were told to recall five SDM and to rate the emotion (valence and arousal) triggered during the retrieval. Specificity, valence, theme, integration and distance in time of the SDM were analysed while controlling for anxiety and depression levels. The SDM construction of the OUD patients was characterised by a lower specificity, more neutral memories and a lower integration, while emotions triggered during retrieval did not differ between the two groups. This may reflect an unsuccessful attempt to disconnect from one's own emotions in the OUD patients. This emotional disconnection and the difficulty of addressing meaning of past events may be due to substance use history coupled with the use of emotional strategies of avoidance. The implications for substance abuse relapse are discussed.

Mind reading abilities in opiate-dependent patients: An exploratory study.

OBJECTIVES: Impairments in social cognition have been described as playing a major role in the maintenance of addictive behavior in substance abusers. This study aimed to investigate the Theory of Mind (ToM) ability of opiate-dependent (OD) patients and to explore whether TOM ability was correlated with length of substance abuse, age at onset of substance abuse and length of abstinence. METHODS: OD patients (N = 29) and non-dependent individuals (NDI) (N = 29) were submitted to the Theory of Mind Assessment Scale (Th.o.m.a.s.), a semi-structured interview, and to the Versailles-Lecture Intentionnelle en Situation (V-LIS), a movie paradigm in which participants have to infer the characters' intentions. RESULTS: The results confirmed a deficit in ToM ability in OD patients, with OD patients demonstrating poorer performance than NDI on both the V-LIS and the Th.o.m.a.s. The combination of perspective taking and reflecting on others' mental states was particularly difficult for OD patients. Furthermore, impairments in ToM abilities were not correlated with the age at onset of substance abuse or to the duration of substance abuse or abstinence. CONCLUSIONS: The results suggest OD patients may have impaired social cognition, demonstrating deficits in even basic social interaction skills, which may constitute a risk factor for addiction. These findings underline the importance of developing interventions to improve social cognition ability during the rehabilitation of OD patients.

Preference for buprenorphine/naloxone and buprenorphine among patients receiving buprenorphine maintenance therapy in France: a prospective, multicenter study.

Maintenance treatment with buprenorphine tablets (Subutex) has been associated with reductions in heroin use; however, concerns for intravenous misuse exist. A buprenorphine/naloxone formulation (Suboxone) was designed to reduce this misuse risk while retaining buprenorphine's efficacy and safety. This prospective, open-label, multicenter trial compared preferences for buprenorphine and buprenorphine/naloxone in 53 opioid-dependent patients stabilized on buprenorphine. Buprenorphine was first administered at the patient's current dose (Days 1-2), followed by a direct switch to buprenorphine/naloxone (Days 3-5). Global satisfaction rates were high and similar between buprenorphine and buprenorphine/naloxone; however, patients preferred the tablet taste, size, and sublingual dissolution time of buprenorphine/naloxone. At the end of the study, 54% of patients preferred buprenorphine/naloxone, 31% preferred buprenorphine, and 15% had no preference; most patients (71%) wished to continue treatment with buprenorphine/naloxone. This study did not identify any impediments to a direct buprenorphine-to-buprenorphine/naloxone switch and revealed some characteristics that may facilitate treatment with buprenorphine/naloxone.

[Analysis of drug consumption among ambulatory patients in a drug agency of Northern France (Lens)]. / Analyse de la consommation de drogues au sein de la population consultant le centre de soins spécialisés pour personnes toxicomanes de Lens.

The aim of this study was to describe and analyze the patterns of illicit psychoactive drug consumption, and the utilization of buprenorphine (BHD) in opiate-dependent patients interviewed in the drug agency of Lens. In our sample, multiple drug use was a massive phenomenon. Misuse of BHD was related to young age, multiple drug injection, gender (male) and risky injecting behavior. Multiple drug use was less frequent among patients with a BHD prescription. It is urgent that health professionals and decision-makers be aware of the heterogeneity of drug consumption habits and their impact on the utilization of drug maintenance treatment. Research is needed to understand the history and motivations for misuse and persistent injecting among some drug users. A national conference of consensus on how to implement and maintain treatments is a necessary step forward in caring for opiate drug addicts.