1.
Pharmazie
; 58(2): 140-2, 2003 Feb.
Article
in English
| MEDLINE
| ID: mdl-12641333
ABSTRACT
Tecostanine (1) was isolated from Tecoma stans leaves. Its sterochemistry was elucidated as well as its antihyperglycemic activity and its affinity to opioid and nicotinic receptors. The oxalate salt of 1 did not significantly affect blood glucose levels in normoglycaemic and hyperglycaemic rats. It did not appear to interact with opioid receptors (mu type) and showed only moderate affinity to the nicotinic receptor.
Subject(s)
Alkaloids/chemistry , Alkaloids/pharmacology , Bignoniaceae/chemistry , Hypoglycemic Agents/chemistry , Hypoglycemic Agents/pharmacology , Plants, Medicinal/chemistry , Terpenes/chemistry , Terpenes/pharmacology , Animals , Crystallography, X-Ray , Magnetic Resonance Spectroscopy , Male , Mexico , Models, Molecular , Molecular Conformation , Rats , Rats, Sprague-Dawley , Receptors, Nicotinic/drug effects , Receptors, Opioid/drug effects
2.
Boll Soc Ital Biol Sper
; 52(9): 595-601, 1976 May 15.
Article
in Italian
| MEDLINE
| ID: mdl-1084757