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1.
Acta Myol ; 34(2-3): 139-40, 2015 Dec.
Article in English | MEDLINE | ID: mdl-27199542

ABSTRACT

We report a 26-year-old woman admitted to our hospital for generalized tonic seizure. Laboratory investigations revealed severe hyponatremia possibly triggered by vomiting and diarrhea. 24 hours after correction of hyponatremia she developed diffuse myalgias and marked hyperCKemia. Syndrome of inappropriate antidiuresis (SIAD) was suspected as cause of hyponatremia. Abnormal vaginal bleeding prompts gynecological evaluation and a small-cell carcinoma of uterine cervix was detected.


Subject(s)
Hyponatremia/diagnosis , Inappropriate ADH Syndrome/diagnosis , Paraneoplastic Syndromes/diagnosis , Rhabdomyolysis/diagnosis , Uterine Cervical Neoplasms/diagnosis , Adult , Diagnosis, Differential , Female , Humans , Hyponatremia/therapy , Inappropriate ADH Syndrome/therapy , Rhabdomyolysis/therapy , Uterine Cervical Neoplasms/therapy
2.
Neurology ; 80(7): 655-61, 2013 Feb 12.
Article in English | MEDLINE | ID: mdl-23345634

ABSTRACT

OBJECTIVE: To assess the impact on stroke outcome of statin use in the acute phase after IV thrombolysis. METHODS: Multicenter study on prospectively collected data of 2,072 stroke patients treated with IV thrombolysis. Outcome measures of efficacy were neurologic improvement (NIH Stroke Scale [NIHSS] ≤ 4 points from baseline or NIHSS = 0) and major neurologic improvement (NIHSS ≤ 8 points from baseline or NIHSS = 0) at 7 days and favorable (modified Rankin Scale [mRS] ≤ 2) and excellent functional outcome (mRS ≤ 1) at 3 months. Outcome measures of safety were 7-day neurologic deterioration (NIHSS ≥ 4 points from baseline or death), symptomatic intracerebral hemorrhage type 2 with NIHSS ≥ 4 points from baseline or death within 36 hours, and 3-month death. RESULTS: Adjusted multivariate analysis showed that statin use in the acute phase was associated with neurologic improvement (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.26-2.25; p < 0.001), major neurologic improvement (OR 1.43, 95% CI 1.11-1.85; p = 0.006), favorable functional outcome (OR 1.63, 95% CI 1.18-2.26; p = 0.003), and a reduced risk of neurologic deterioration (OR: 0.31, 95% CI 0.19-0.53; p < 0.001) and death (OR 0.48, 95% CI 0.28-0.82; p = 0.007). CONCLUSION: Statin use in the acute phase of stroke after IV thrombolysis may positively influence short- and long-term outcome.


Subject(s)
Fibrinolytic Agents/therapeutic use , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Stroke/drug therapy , Tissue Plasminogen Activator/therapeutic use , Aged , Aged, 80 and over , Female , Humans , Logistic Models , Male , Middle Aged , Multivariate Analysis , Neurologic Examination , Outcome Assessment, Health Care , Prospective Studies , Retrospective Studies , Severity of Illness Index , Time Factors , Tomography Scanners, X-Ray Computed
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