ABSTRACT
Effect was studied of acetate haemodialysis with ultrafiltration (HD) on left ventricular (LV) systolic and diastolic function of 25 uraemic patients (age: 19-49 years, x = 33.6, SD = 8.9) treated by HD. M-Mode, 2D-, and Doppler-echocardiography was performed to determine LV filling pattern, LV end-systolic (LVIDS) and end-diastolic diameter (LVIDD) immediately before and after each hour of HD. Values of LV mass index (LVMI), fractional shortening (FS), ejection fraction (EF) and velocity of circumferential fiber shortening (Vcf) were also assessed. Simultaneously creatinine, magnesium, potassium, natrium and ionized calcium concentrations were measured, together with body weight and blood pressure. Left ventricular dimensions and LVMI were greatly increased in uremic patients as compared to 25 healthy subjects of similar age. HD resulted in a significant (p < 0.005) lowering of creatinine and potassium concentrations, a nonsignificant decrease of sodium and magnesium levels and in a significant (p = 0.05) increase a significant decrease of LVIDD, LVIDS, Ve,Ve/Va (p < 0.05) and a nonsignificant increase of FS, EF and Vcf. An effective volume depletion HD has no significant influence on left ventricular systolic function and a negative influence on its filling pattern.
