Features of exocrine pancreatic insufficiency in patients with non-alcoholic fatty liver disease in combination with type 2 diabetes and COVID-19.

OBJECTIVE: Aim: The aim of the research was to study the features of pancreatic exocrine insufficiency (EPI) in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM) at COVID-19. PATIENTS AND METHODS: Materials and Methods: 72 patients with NAFLD and COVID-19 were examined. The patients have been divided into two groups: group 1 included 42 patients with NAFLD and insulin resistance (IR); group 2 consisted of 30 patients with NAFLD in the combination with type 2 DM. EPI was detected by 13С-mixed triglyceride breath test (13С-MTBT) in all the patients. RESULTS: Results: The result of 13С-MTBT indicates EPI in the examined subjects of the 2 group. A significant decrease in the maximum concentration of 13СО2 between 150 and 210 min was also diagnosed in group 1 patients. research (up to 8.2 ± 0.9% - p < 0.05), however, the total concentration of 13СО2 at the end of 360 min. the study reached only 27.7 ± 1.1% (p < 0.05). CONCLUSION: Conclusions: Based on the results of laboratory-instrumental methods of research, patients with NAFLD and type 2 diabetes with COVID-19 were diagnosed with severe EPI. The results of 13С-MTBT in NAFLD and IR with COVID-19 indicate a decrease in the functional reserves of the pancreas and the formation of its EPI.

Dynamic indicators of acute respiratory diseases treatment in children after correction.

OBJECTIVE: Aim: To study the Respiratory pathology of the upper respiratory tract, markers of the inflammatory response of the organism, Oxidative stress, Metabolic adaptation and possibilities of correction. PATIENTS AND METHODS: Materials and Methods: The study group (n=111) included school-aged children (10-14 years old). The general group of inflammatory diseases of the respiratory tract (J000-J06) was considered, with a diagnosis of acute respiratory infection (ARI) of viral and bacterial origin and included local inflammationof the upper respiratory tract with presentation of acute pharyngitis (68.0%), acute bronchitis (22,0%), acute tonsillitis (10,0%). RESULTS: Results: Dynamic observation of groups of children who received optimized (group 1, n=60) and basic (group 2, n=51) treatment was carried out. The level of the erythrocyte pool correlated with IL-1 (r=-0,29, p=0,03), IL-4 (r=0,32, p=0,01), TNF-α (r=-0,35 , p=0,006). Creatinine value correlated with IL-10 (r=0,3, p=0,005), γ-IFN (r=0,42, p=0,001), TNF-α (r=0,25, p=0,05). Correlations of ferritin presented positive correlation values with the level of total protein (r=0,26, p=0,04) and TNF-α (r=0,41, p=0,001). CONCLUSION: Conclusions: After the optimized treatment, there was a significant decrease in the reliable levels of CRP and γ-IFN by 7 and 4,4 times (by groups) and 5,8 and 3,2 times (by groups), respectively. Correlation relationships of urea levels with IL-2,4 were detected. The level of the erythrocyte pool correlated with IL-1,4, TNF-α, Ferritin presented positive correlation values with the level of total protein,TNF-α .

EVALUATION RESULTS OF THE USE OF MODERN INTERNET SOURCES BY THE STUDENTS OF VOCATIONAL EDUCATION INSTITUTIONS FOR THE FORMATION OF HEALTH AWARENESS.

OBJECTIVE: The aim: Is toevaluate students' use of online tools to obtain information on health and healthy lifestyle. PATIENTS AND METHODS: Materials and methods: A sociological survey was conducted among 1,563 students of vocational education institutions in Transcarpathian region, using a specially designed questionnaire on the use of information and communication channels to inform about health and healthy lifestyle. RESULTS: Results: It was found that a large proportion of students of vocational education institutions (71.8 ± 2.2%) spend more than 2 hours a day browsing Internet resources, which makes it possible to use these information and communication channels to inform about health and healthy lifestyle. The most relevant sources of information about health for young people are social networks Facebook (58.3±2.4%) and Instagram (56.7±2.5%), webpages of famous doctors (34.9±2.4%) and official websites of health care institutions (32.4±2.3%). CONCLUSION: Conclusions: Effective use of modern information and communication channels for health promotion among students aged 15-18 is possible taking into account the preferences of the target group, their features, reliable information content.

Traumatism and some aspects of trauma care in transcarpathian region as a part of public health.

OBJECTIVE: The aim is to study and analyze the levels of general traumatism of the population, some aspects of trauma care in Transcarpathian region regarding administrative units. PATIENTS AND METHODS: Materials and methods: Medical-statistical, graphic and biblio-semantic methods were used. The data of sectoral statistical reporting in Transcarpathian region for 2014-2018 formed the base of the study. RESULTS: Results: It is determined that the highest rates of traumatism (over 470 per 10 thousand population) are characteristic for the eastern districts of the region; the average indicators (260-470 per 10 thousand population) - for the northern and southern ones, and the lowest (less than 260 per 10 thousand population) - for the central and western parts of the region. The inequality of distribution of traumatological beds in the region in relation to the levels of injury in the administrative territories was determined. CONCLUSION: Conclusions: With the established tendency to decrease of general traumatism in Transcarpathian region for the period 2014-2018, significant inequalities of the specified indicator and inconsistency of traumatological beds availability in the administrative territories were revealed.

Syndromal characteristics of the combined course of chronic pancreatitis and arterial hypertension.

OBJECTIVE: The aim:To study the clinical course of chronic pancreatitis (CP) in patients with concomitant hypertension. PATIENTS AND METHODS: Materials and methods: A thorough analysis of the results of subjective and clinical and laboratory examinations of 102 patients with CP, who were hospitalized in the therapeutic department of Khust district hospital during 2017-2018 was conducted. RESULTS: Results: Takingintoaccount that the initial examination of patients was carried out during the period of exacerbation of the disease, all patients presentedwith pain syndrome (100%).The overwhelming majority of patients identified pain as permanent aching discomfort in the abdominal cavity with periodic intensification (n = 41 (40,2%), 18 patients indicated burning pain (17,6%), 30 - cutting (29,4%) ), and 13 (12,7%) experienced pain of varying nature.due to the presence of hypertension (GC) 73 (71.6%) patients complained of a headache of a paroxysmal periodic pulsating character, which was most often localized in the occipital-frontal area and was accompanied by dizziness, "flickering of flies" before the eyes, noise in the ears. Also, 14 (13,7%) patients had shortness of breath at moderate physical exercise, lower extremity edema that appeared in the afternoon and disappeared by the morning.In addition, 33 (32,4%) surveyed patients indicated a periodic heartbeat.In 18 (17,7%) patients sporadic dizziness was observed. The level of blood pressure (BP), which was established in the studied patients, corresponded to arterial hypertension of grade 1-2 (154,15 ± 9,24 / 94,53 ± 9,05 mm Hg). In terms of heart rate (HR) in the examined patients, it was 80.26 ± 10.73 beats per minute. CONCLUSION: Conclusions: According to the study, the negative impact of concomitant hypertension on the clinical course of chronic pancreatitis was established, namely: hypertension in most cases causes intensification of pain syndrome; pain syndrome in comorbid patients with cronic pancreatitis and arterial hypertension is accompanied by more pronounced manifestations of asthenisation: general weakness, lethargy;dependence of the duration of pain syndrome from the height of blood pressure and the duration of arterial hypertension was found; dyspepsia syndrome is more pronounced, varied and prolonged in patients with high blood pressure; smoking (37,3%), alcohol (19,6%), psychoemotional overload (6,9%) are common etiologic factors in comorbid patients with chronic pancreatitis and arterial hypertension; BMI results indicate the dominance of excess body mass in most comorbid patients with chronic pancreatitis and arterial hypertension.