[Residues of chlorinated hydrocarbons in livers of newborns, infants and children]. / Pozostalosci chlorowanych weglowodorów w watrobach noworodków, niemowlat i dzieci.

In the liver of 4 newborns, 2 infants and 2 children the levels of residues of chlorinated hydrocarbons were determined. The highest levels of sigma HCH (817 mcg/kg of fat, 17.1 mcg/kg of tissue) were found in a 2-day-old newborn, the lowest ones (43 mcg/kg of fat, 1.8 mcg/kg of tissue) were in an infant aged 12 months. The content of sigma DDT was highest (3044 mcg/kg of fat, 93.8 mcg/kg of tissue) in the liver of an infant aged 13 days, the lowest values (322 mcg/kg of fat, 5.6 mcg/kg of tissue) in the liver of a child aged 12 years. The results are comparable to those obtained in this country in the liver of adults and in human placenta.

[Lead contents in liver and kidney of inhabitants of the city of Bialystok and vicinity]. / Zawartosc olowiu w watrobach i nerkach mieszkanców Bialegostoku i okolic.

The material comprised liver and kidney samples collected from inhabitants of the city of Bialystok and of its vicinity during anatomopathological examination at the Department of Pathological Anatomy, Medical Academy in Bialystok. In age groups: 2 days-8 years, 29-65 years, 66-84 years, the mean liver lead content was 0.220, 0.211 and 0.233 mg/kg, respectively. The mean kidney lead content amounted to 0.272, 0.038 and 0.125 mg/kg, respectively. When compared with the literature data for subjects not exposed to lead, the present results have to be regarded as low. The newborn displayed a higher kidney lead level than adults. In contrast to adults, in the newborn the content of lead in the kidney exceeded that in the liver. Adults showing a higher lead level in the liver than in the kidney exhibited a correlation between Pb level in the liver and kidney (r = 0.671).

[Atrophy of the bone marrow]. / Zanik szpiku kostnego.

The authors made a quantitative analysis of the active hematopoietic tissue of the bone marrow with particular consideration of its atrophy in the course of various diseases. The material consisted of 407 non-selected autopsy cases. For a morphometric analysis the bone marrow was sampled from the sternum, ala ossis illi and spine. In the quantitative analysis of the active hematopoietic tissue we took into account age groups as quantitative changes appear with age. Atrophy of the bone marrow was in 19.4% of the studied cases. The presence of bone marrow atrophy was found in the course of various diseases, most frequently neoplastic, particularly in patients aged from 50 to 59 years.

[Gelatinous transformation of the bone marrow]. / Zwyrodnienie galaretowate szpiku kostnego.

The incidence and histopathologic picture of gelatinous transformation of the bone marrow were analysed in non-selected autopsy material. It was found that gelatinous transformation of the bone marrow occurred in terminal stages of various diseases (malignant neoplasms, chronic inflammation). Histological studies showed that gelatinous transformation of the bone marrow led to atrophy of the hematopoietic and adipose tissues of the bone marrow and accumulation of acid mucopolysaccharides. The patients with gelatinous transformation of the bone marrow exhibit hematologic disorders, most frequently anemia and thrombocytopenia.

[Coexistence of polycystic kidney and other developmental defects. Analysis of autopsy specimens 1953-1985]. / Wspólistnienie wielotorbielowatego zwyrodnienia nerek (wzn) z innymi wadami rozwojowymi. Analiza materialu sekcyjnego w latach 1953-1985.

The cases of polycystic disease of kidney selected from 33 years postmortem data were presented. They were classified into 4 types (according to Osathanond, Potter and Heptinstall) and the results correlated with accompanying malformations. It has been established that type I of polycystic disease of kidney was mostly correlated with CNS, skull and spine abnormalities. Type II and III were coexisting with genitourinary and ++gastrointestinal system malformations. No type IV of the disease has been found.

[Neoplastic metastases in the bone marrow from cancers of the digestive system (stomach, pancreas, liver and gallbladder]. / Przerzuty nowotworowe do szpiku kostnego w niektorych rakach przewodu pokarmowego (zoladka, trzustki, watroby i pecherzyka zólciowego).

The authors analyse the incidence of metastases into the bone marrow in carcinomas of the stomach, pancreas, liver and gallbladder. Specimens from the bone marrow taken were by trephine biopsy from the sternum, ala ossis ilii and spine. Metastases into the bone marrow were found in carcinomas of the stomach, pancreas and gallbladder but not in hepatic carcinoma. Neoplastic metastases were most frequent in adenocarcinoma of the stomach.

[Necrosis of the bone marrow]. / Martwica szpiku kostnego.

The authors analyzed the incidence of necrosis of the bone marrow in nonselected autopsy material. The studies included 419 cases of various disease types. Necrosis of the bone marrow was found in 83 cases (19.8%). It was most frequently observed in patients with neoplastic disease of the hematopoietic and lymphatic systems (26.3%) and malignant neoplasms of different origin (21.9%). In 40% cases necrosis of the bone marrow were accompanied by neoplastic metastases into the hematopoietic tissue, and thrombotic changes in the blood vessels occurred in 22.9% of these cases. Our results point to a fairly frequent occurrence of necrosis of the bone marrow, especially in the course of neoplastic disease.

[Chlorinated hydrocarbon residues in the livers of the population of Bialystok and its environs]. / Pozostalosci chlorowanych weglowodoròw w watrobach mieszkanców Bialegostoku i okolic.

In the livers of 34 subjects living in Bialystok and environs the residues of chlorinated hydrocarbons were determined. The mean values of alpha-HCH, beta-HCH, gamma-HCH, DDE, DDD, DDT and sigma DDT were respectively 16, 60, 81, 1090, 94, 177 and 1361 mcg/kg of fat, and 0.5, 3.2, 3.3, 48, 5.0, 7.1 and 60 mcg/kg of tissue. The content of DDE and sigma DDT in liver fat was similar to that found previously in perirenal fat. In relation to perirenal fat the content of DDT in liver fat was lower and that of DDD was higher. This was due, probably, to metabolic changes taking place in the liver. The relationship between beta-HCH and gamma-HCH in the liver was different from that in fatty tissue in which the level of Indian was lower than that of the beta-isomer.

[Chlorinated hydrocarbon residues in the adipose tissue of the population of BiaLystok and its environs]. / Pozostalosci chlorowanych weglowodorów w tkance tluszczowej mieszkanców Bialegostoku i okolic.

In the perirenal fat tissue of 36 representatives of this population (20 men and 16 women aged 41 to 92 years) the levels were determined of the residues of alpha-, beta-, and gamma-HCH, DDE, DDD, DDT and sigma DDT. The obtained mean values were 0.012, 0.013, 0.007, 1.421, 0.035, 0.327 and 1.783 mg/kg of fat, respectively. The obtained results were severalfold lower than those found in Poland in the 1970s. The fat of the human fat tissue contained high amounts of beta-HCH as compared to other isomers of hexachlorocyclohexane, and high amount of DDE in sigma DDT. In the fat of men the residues of DDE and sigma DDT were present in greater amounts than in women. On the other hand, no effect of age was noted on the levels of the residues of chlorinated hydrocarbons in human fat.