ABSTRACT
Experiments on animals with experimental lipogenic pancreatitis showed that disturbances in lipid metabolism stimulate destructive processes in the pancreas, liver, and spleen. Acute experimental lipogenic pancreatitis is characterized by extensive destructive changes in the pancreatic parenchyma accompanied with fatty necrobiosis of hepatocytes, fatty transformation of the gallbladder wall, and pronounced reaction of the reticuloendothelial stroma in the spleen.
Subject(s)
Lipid Metabolism , Liver/pathology , Pancreas/pathology , Pancreatitis/metabolism , Pancreatitis/pathology , Acute Disease , Animals , Biliary Tract/pathology , Disease Models, Animal , Duodenum/pathology , Gallbladder/pathology , Rabbits , Spleen/pathologyABSTRACT
Dyslipoproteinemia was induced and corrected in 40 Chinchilla rabbits. Lipid metabolism disorders were corrected by Fishant vaseline-pectin emulsion and partial ileoshunting. Experimental dyslipoproteinemia initiated destructive dystrophic processes in the hepatopancreatobiliary organs manifesting by liver stenosis, gallbladder cholesterosis, and focal structural and functional disorders in pancreatic parenchyma. Correction of dyslipoproteinemia normalized the status of hepatopancreatobiliary organs, decreased the severity of destructive processes, and prevented their further development.
