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Bioorg Med Chem Lett
; 13(10): 1751-3, 2003 May 19.
Article
in English
| MEDLINE
| ID: mdl-12729657
ABSTRACT
A C-8 keto pleuromutilin derivative has been synthesized from the biotransformation product 8-hydroxy mutilin. A key step in the process was the selective oxidation at C-8 of 8-hydroxy mutilin using tetrapropylammonium perruthenate. The presence of the C-8 keto group precipitated interesting intramolecular chemistry to afford a compound (10) with a novel pleuromutilin-derived ring system.