[Clinical relevance of haptoglobin/IgG index and Boyer's score to the differential diagnosis of bacterial and viral meningitis]. / Relevancia clínica del índice haptoglobina/IgG y la escala de Boyer en el diagnóstico diferencial de las meningoencefalitis bacterianas y víricas.

INTRODUCTION: The meningitis is one of the most severe diseases in children due to its mortality or sequels. However, timely knowledge of whether the infection is bacterial or viral in origin and applied a specific therapeutic would be beneficial for the patients and clinician. The haptoglobin/IgG index and Boyer's score have been use in this purpose. PATIENTS AND METHODS: 39 pediatric patients, 14 suffering from viral meningoencephalitis and 25 from bacterial meningoencephalitis were study. Boyer's score and Hp/IgG index were applied in order to evaluate its diagnostic accuracy. The clinical relevance of haptoglobin/IgG index and Boyer's score were compared by the analysis of the receiver-operating characteristic (ROC) curves. RESULTS: There were no association between Boyer's score and the cause of the meningitis. The sensitivity and specificity of haptoglobin/IgG index were de 71.4 and 64%, respectively. The same parametric to Boyer's score were de 28 and 100%. Increased haptoglobin/IgG index presents bigger precision for the differential diagnostic of the bacterial and viral meningitis than the scale of Boyer according to the curves ROC. CONCLUSION: The index haptoglobin/IgG showed its diagnostic superiority with relationship to the scale of Boyer to establish the origin of the meningoencephalitis.

Relevancia clínica del índice haptoglobina/IgG y la escala de Boyer en el diagnóstico diferencialde las meningoencefalitis bacterianas y víricas / Clinical relevance of haptoglobin/IgG index and Boyer's score to the differential diagnosis of bacterial and viral meningitis

ntroducción. Las meningoencefalitis son una de las enfermedades más temidas en la infancia, tanto por su mortalidadcomo por sus posibles secuelas. Sin embargo, conocer tempranamente si su origen es bacteriano o vírico e instauraruna terapéutica adecuada resulta muy beneficioso para el paciente y el médico de asistencia. El índice haptoglobina/IgG y la escala de Boyer se han utilizado con estos fines. Pacientes y métodos. Se estudiaron 39 pacientes en edad pediátrica con eldiagnóstico de meningoencefalitis: 14 que sufrían meningoencefalitis bacterianas y 25 meningoencefalitis víricas. Se calculó el índice haptoglobina/IgG y se le aplicó la escala de Boyer para conocer su utilidad en el diagnóstico diferencial de las meningoencefalitis. La relevancia clínica del índice haptoglobina/IgG y la escala de Boyer se compararon a través de las curvas ROC. Resultados. La escala de Boyer no presentó asociación estadísticamente significativa con el origen de las meningoencefalitis.La sensibilidad y especificidad del índice haptoglobina/IgG fueron del 71,4 y el 64 por ciento, respectivamente, para iguales parámetros en la escala de Boyer del 28 y el 100 por ciento. El índice haptoglobina/IgG presentó mayor precisión para el diagnósticodiferencial de las meningitis bacterianas y víricas que la escala de Boyer a través del área bajo la curvas ROC. Conclusiones. El índice haptoglobina/IgG mostró su superioridad diagnóstica con relación a la escala de Boyer para establecer el origen de las meningoencefalitis(AU)

INTRODUCTION: The meningitis is one of the most severe diseases in children due to its mortality or sequels. However, timely knowledge of whether the infection is bacterial or viral in origin and applied a specific therapeutic would be beneficial for the patients and clinician. The haptoglobin/IgG index and Boyer's score have been use in this purpose. PATIENTS AND METHODS: 39 pediatric patients, 14 suffering from viral meningoencephalitis and 25 from bacterial meningoencephalitis were study. Boyer's score and Hp/IgG index were applied in order to evaluate its diagnostic accuracy. The clinical relevance of haptoglobin/IgG index and Boyer's score were compared by the analysis of the receiver-operating characteristic (ROC) curves. RESULTS: There were no association between Boyer's score and the cause of the meningitis. The sensitivity and specificity of haptoglobin/IgG index were de 71.4 and 64 percent, respectively. The same parametric to Boyer's score were de 28 and 100 percent. Increased haptoglobin/IgG index presents bigger precision for the differential diagnostic of the bacterial and viral meningitis than the scale of Boyer according to the curves ROC. CONCLUSION: The index haptoglobin/IgG showed its diagnostic superiority with relationship to the scale of Boyer to establish the origin of the meningoencephalitis(AU)

Relevancia clínica del índice haptoglobina/IgG y la escala de Boyer en el diagnóstico diferencial de las meningoencefalitis bacterianas y víricas / Clinical relevance of haptoglobin/IgG Index and boyer's score to the differential diagnosis of baterial and viral meningitis

Introducción. Las meningoencefalitis son una de las enfermedades más temidas en la infancia, tanto por su mortalidad como por sus posibles secuelas. Sin embargo, conocer tempranamente si su origen es bacteriano o vírico e instaurar una terapéutica adecuada resulta muy beneficioso para el paciente y el médico de asistencia. El índice haptoglobina/IgG y la escala de Boyer se han utilizado con estos fines. Pacientes y métodos. Se estudiaron 39 pacientes en edad pediátrica con el diagnóstico de meningoencefalitis: 14 que sufrían meningoencefalitis bacterianas y 25 meningoencefalitis víricas. Se calculó el índice haptoglobina/IgG y se le aplicó la escala de Boyer para conocer su utilidad en el diagnóstico diferencial de las meningoencefalitis. La relevancia clínica del índice haptoglobina/IgG y la escala de Boyer se compararon a través de las curvas ROC. Resultados. La escala de Boyer no presentó asociación estadísticamente significativa con el origen de las meningoencefalitis. La sensibilidad y especificidad del índice haptoglobina/IgG fueron del 71,4 y el 64%, respectivamente, para iguales parámetros en la escala de Boyer del 28 y el 100%. El índice haptoglobina/IgG presentó mayor precisión para el diagnósticodiferencial de las meningitis bacterianas y víricas que la escala de Boyer a través del área bajo la curvas ROC. Conclusiones. El índice haptoglobina/IgG mostró su superioridad diagnóstica con relación a la escala de Boyer para establecer el origen de las meningoencefalitis

Introduction. The meningitis is one of the most severe diseases in children due to its mortality or sequels. However, timely knowledge of whether the infection is bacterial or viral in origin and applied a specific therapeutic would be beneficial for the patients and clinician. The haptoglobin/IgG index and Boyer’s score have been use in this purpose. Patients and methods. 39 pediatric patients, 14 suffering from viral meningoencephalitis and 25 from bacterial meningoencephalitis were study. Boyer’s score and Hp/IgG index were applied in order to evaluate its diagnostic accuracy. The clinical relevance ofhaptoglobin/IgG index and Boyer’s score were compared by the analysis of the receiver-operating characteristic (ROC) curves.Results. There were no association between Boyer’s score and the cause of the meningitis. The sensitivity and specificity of haptoglobin/IgG index were de 71.4 and 64%, respectively. The same parametric to Boyer’s score were de 28 and 100%. Increased haptoglobin/IgG index presents bigger precision for the differential diagnostic of the bacterial and viral meningitisthan the scale of Boyer according to the curves ROC. Conclusion. The index haptoglobin/IgG showed its diagnostic superiority with relationship to the scale of Boyer to establish the origin of the meningoencephalitis