The Alleviation of Dextran Sulfate Sodium (DSS)-Induced Colitis Correlate with the logP Values of Food-Derived Electrophilic Compounds.

Food-derived electrophilic compounds (FECs) are small molecules with electrophilic groups with potential cytoprotective effects. This study investigated the differential effects of six prevalent FECs on colitis in dextran sodium sulfate (DSS)-induced mice and the underlying relationship with molecular characteristics. Fumaric acid (FMA), isoliquiritigenin (ISO), cinnamaldehyde (CA), ferulic acid (FA), sulforaphane (SFN), and chlorogenic acid (CGA) exhibited varying improvements in colitis on clinical signs, colonic histopathology, inflammatory and oxidative indicators, and Nrf2 pathway in a sequence of SFN, ISO > FA, CA > FMA, CGA. Representative molecular characteristics of the "penetration-affinity−covalent binding" procedure, logP value, Keap1 affinity energy, and electrophilic index of FECs were theoretically calculated, among which logP value revealed a strong correlation with colitis improvements, which was related to the expression of Nrf2 and its downstream proteins. Above all, SFN and ISO possessed high logP values and effectively improving DSS-induced colitis by activating the Keap1−Nrf2 pathway to alleviate oxidative stress and inflammatory responses.

Online Emotional Support Accompany Group Intervention and Emotional Change of the Public During the COVID-19 Pandemic: A Multi-Period Data Analysis From China.

COVID-19 has made it difficult to adopt traditional face-to-face psychological intervention under this situation because of the blocked down and social distancing, which brings big psychological crisis to the public among the global. To explore the emotional change of the public in China at the outburst of the pandemic at different phases, to establish an online working platform and create a new model of an online intervention to hold public emotions under pandemic, and test its effectiveness, so to give advisement for government emergency management system. We established an online organization to work for this program ad innovated a model of online group counseling with online emotional support accompany group (OESAG) right after the outburst of a pandemic. We analyzed 53 OESAGs from February 10 to April 9, including 555 application forms, 253 feedback from members, and 139 feedback from group leaders by using NVivo and SPSS to explore the evolution and characteristics of public emotion during COVID-19 and the effectiveness of OESAG. Our results showed that the emotional changes of members ranged from shock to depression to positive. The public's emotions swiftly changed from stress, anxiety, and isolation, to the hope of returning to work or finding a job during the pandemic with the help of OESAG. OESAG has effectively regulated the negative emotions of members by conducting psychological crisis intervention to provide members a space to communicate with each other, especially the female and frontline staff. Policy makers can set up an online systematic psychological crisis intervention system as soon as possible to make up for the lack of psychological assistance in the emergency management system.

The Impact of Informal Social Support on Older Health: Evidence from China.

OBJECTIVES: To explore the impact of informal social support (ISS) on older health. METHODS: Multiple regression was used as the baseline regression, grouping regression was used to examine whether there were health effect differences among groups based on age and household registration, and insurance was selected to explore moderating effects of formal social support (FSS). RESULTS: First, economic support, accompanied support, and number of intimate contacts had significantly positive effects on older health except for care support's negative effects. Second, ISS had different health effects for different groups based on age and household registration. Third, FSS was a significant moderating for ISS. CONCLUSIONS: The government should emphasize and strengthen the supplementary role of ISS to FSS and promote the effective combination of the two, especially for the older who are high-age and rural, and further improve the role of care support.

Treatment and recycling of acidic fracturing flowback fluid.

Acidic fracturing flowback fluid (AFFF) has the characteristics of low pH value, high chemical oxygen demand (COD), high corrosiveness and complex components. Surface discharge without treatment may contaminate the environment. However, wastewater treatment after centralized transportation has potential safety risks and requires high costs. In this study, we confirmed that calcium and magnesium could affect cross-linking property of fracturing fluid prepared by flowback fluid, and conducted a three-step process, two-stage filtration, chemical precipitation, and flocculation precipitation, on AFFF. After treatment, we made new hydraulic fracturing fluid using the treated acidic flowback fluid as base fluid and compared the quality of the new hydraulic fracturing fluid to the ones used freshwater as base fluid. The results showed when concentration of sodium carbonate, polyaluminium chloride (PAC), polyacrylamide (PAM) were 145, 1000, and 20 mg/L respectively, the treatment result was optimal. After treatment, the oil content of AFFF decreased from 7400 to 26.53 mg/L and suspended solids (SS) from 650 to 18.24 mg/L, and the removal rate of high-valence metal ions was more than 99%. The rheological properties and viscoelasticity of new fracturing fluid prepared by the treated AFFF were similar to the ones prepared by freshwater, which met the requirements of high temperature and shear resistance for ultra-deep wells.

Mobility-related inequality in healthcare utilization between floating and native populations and its influencing factors: evidence from China.

Our goal was to examine inequality in healthcare utilization and the factors that contribute to inequality between China's floating and native populations. Based on the China Labor-force Dynamics Surveys from 2014 to 2018, which used three rounds of data, we utilized a panel probit model that included fixed effects for time and province to estimate the probability of healthcare utilization for floating and native populations. In addition, we calculated the degree of inequality in healthcare utilization by using the method of mobility-related inequality and a decomposition approach was used to explain the contribution of each factor to the inequality. The floating population utilized healthcare at a lower rate, with a 10.5% probability of visiting a hospital and a 20.9% probability of receiving hospitalized treatment. The concentration index of mobility-related inequality in healthcare utilization shows a negative coefficient of -0.137 for hospital visits and -0.356 for hospitalized treatment. Contribution decomposition shows that self-assessed health, job category and household registration account for the largest contribution to the inequality in hospital visits, contributing -0.038, 0.021 and -0.017, respectively. Age, household registration and insurance account for the largest contribution to the inequality in hospitalized treatment, contributing -0.053, 0.024 and -0.023, respectively. The floating population was less likely to use health services and faced an inequality in treatment compared with the native population.

Association of High-Speed Rail and Tuberculosis Transmission in Newly Integrated Regions: Quasi-Experimental Evidence from China.

Objectives: The spread of tuberculosis (TB) is related to changes in the social network among the population and people's social interactions. High-speed railway (HSR) fundamentally changed the integrated market across cities in China. This paper aims to examine the impact of HSR on TB transmission in newly integrated areas. Methods: By exploiting the opening and operation of the first HSR in Sichuan province as a quasi-natural experiment, we have collected and used the economic, social, and demographic data of 183 counties in Sichuan province from 2013 to 2016. Results: The new HSR line is associated with a 4.790 increase in newly diagnosed smear-positive TB cases per 100,000 people among newly integrated areas. On average, an additional increase of 34.178 newly diagnosed smear-positive TB cases occur every year in counties (or districts) covered by the new HSR. Conclusion: HSR development has significantly contributed to the transmission of TB. The public health system in China needs to pay more attention to the influences of new, mass public transportation.

Will high-speed railway influence the healthcare seeking behaviour of patients? Quasi-experimental evidence from China.

This study examines the impacts of high-speed railway (HSR) transportation on the healthcare-seeking behaviour of patients along newly integrated areas of Sichuan province, China. The opening of the Cheng-Mian-Le intercity HSR is considered as quasi-experimental evidence from China, and we make a propensity score matching the difference in differences research design, using data from the monthly report database of the Sichuan Province health statistical data collection and Decision Support System from 2014 to 2015. We find that, first, the opening of the HSR resulted in significant healthcare-seeking behaviour with great heterogeneity. Second, patients are more likely to go to areas with high-density healthcare resources, in which case HSR may mitigate the diagnostic inaccuracies that patients face locally. Third, the 'distance enhancement effect' was present, and its marginal effect is more significant for long-distance patients. Fourth, the tiered-network healthcare policy has no significant restrictive impact on patients seeking high-level medical services. Our results show that HSR establishment has a substantial impact on the behaviour of people seeking medical treatment and medicine. Furthermore, we discuss the results' policy implications for the allocation and integration of China's healthcare market, and the accessibility of medical and health services.

Trends in Dietary Patterns and Diet-related Behaviors in China.

Objectives: Determination of trends in diet-related behaviors and their interactions with cardio-metabolic diseases is an important research endeavor. Methods: We analyzed food categories, weight, eating frequency, eating location, cooking methods, time of food intake, dietary knowledge, food preference, nutritional structure over time, and their interaction with cardiometabolic risks, using t tests and χ² tests, based on the China Health and Nutrition Survey packages from 1997 to 2011. Results: Consumption of fruits, dairy products, snacks, fast food, and beverages has increased significantly, as a concomitant and marked decrease in rice consumption has occurred. Food categories, eating frequency, cooking methods, and at-home eating are gradually increasing and diversifying. Persons not only prefer to consume carbohydrate-rich foods like fruits and vegetables, but also enjoy energy-dense foods like meat, snacks, and beverages. There has been a switch from a predominantly plant-based diet to a Western style diet high in fat and animal-based foods. People have undergone significant changes in reducing the intake of energy, carbohydrates, and protein, but significantly increased their fat intake. Conclusion: Chinese dietary patterns and diet-related behaviors have undergone significant transition in the past few decades, trending towards diversification and modernization.

Differences in Overweight and Obesity between the North and South of China.

Objective: Determining geographical distribution and local dietary patterns involved in being obese is useful for designing intervention strategies. Methods: We selected residents between 18 and 65 years old from 11 Chinese provinces to compare dietary patterns and BMI from the China Health and Nutrition Survey packages in 2011. We used linear and logistic regression analyses to assess the strength of association among geographic variables, the obesity problem, and dietary patterns. Results: The overall prevalence of overweight and obesity in the North was 10.51% higher than that in the South. Northern dietary patterns feature a high intake of wheat and soybeans, whereas southern dietary patterns feature a high intake of rice, vegetables, meat, and poultry. The estimated coefficient of regional variables on dietary score is 1.49, the estimated coefficient of regional variables on the odds ratio for being overweight is 1.68 and for being obese is 2.04. Multivariate logistic regression including both variables of South-North areas and northern dietary patterns showed a significant correlation with being overweight or obese. Conclusions: Northern areas and their local dietary patterns are more likely to contribute to overweight and obesity. Our study provides empirical evidence for policies that target the ''obesogenic'' environment and promote opportunities for persons to access healthy dietary patterns and nutritional balance.

The Impact of Mothers' Dietary Patterns on Children's Nutritional Status in China.

Objective: We studied the effect of mothers' dietary patterns on their children's nutritional status. Methods: Based on the China Health and Nutrition Survey (CHNS) packages in 2004, 2006, 2009, and 2011, mothers' dietary quality scores were calculated using the Dietary Balance Index-07. We further explored the influence of maternal dietary patterns on children's nutritional status using a series of regression analyses with time and province fixed effects in longitudinal study, simultaneouly considering the differential impact of child's age, multigenerational co-residence, and categories of maternal food consumption. Results: Maternal food consumption was slightly higher than what is required, and each food group positively correlated between mothers and their children. Furthermore, the maternal dietary quality score on the children's energy intake was significant. The influence of maternal dietary patterns on children's nutritional intake increases gradually with the child's age, but multigenerational co-residence has the opposite effect. Furthermore, maternal food intake of cereals, vegetables, beans, and meat has a positive impact on children's nutritional intake. Conclusions: Maternal dietary patterns have a significant impact on children's nutritional status. The consumption of meat and multigenerational co-residence should be given high priority.

Biomechanical study of space frame structure based on bone cement screw.

Stability of space frame structures with bone cement screw reinforcement by biomechanical testing was analyzed. Seven complete human spine specimens with osteoporosis were selected. Three specimens were separated into 18 vertebral bodies. Nine vertebral bodies were randomly selected and bone cement screws were implanted on both sides. Bone cement was used to form a bridge at the front end of the two screws (single vertebral group A). The other nine vertebral bodies were implanted with cement screws on both sides, but the front ends of the two screws were not bridged (single vertebral group B). The remaining spine specimens were used for biomechanical testing of the overall stability of the three-dimensional frame. The four specimens were osteotomized, and then two specimens were randomly selected. Bone cement screws were implanted on both sides of the vertebral body, and a bone cement bridge was formed at the front end of the two screws to establish a three-dimensional frame structure (multi-vertebral group A). The other two spine specimens were implanted with cement screws on both sides of the vertebral body, but the front ends of the two screws were not bridged (multi-vertebral group B). A statistical difference was found between the extractive force of bridged and non-bridged specimens. Group B showed some loosening of screws after the test. The stability of the triangle structure screw, which was formed after the bridge was established at the front end of the single-vertebral bone cement screw, was significantly enhanced. Moreover, the stability was significantly improved after the three-dimensional frame structure was established in the multi-vertebral body group, providing a new method for clinical improvement of the stability and reliability of internal fixation in patients with severe osteoporosis and spinal disease.

Are parental dietary patterns associated with children's overweight and obesity in China?

BACKGROUND: It is believed that parents have a great influence on their children's dietary behaviours. However, it is not clear whether parental food patterns are associated with children's nutritional status in China, which includes a vast territory with rich, diverse cultures. The goal of this project is to systematically study the associations between parental food intake and children's overweight and obesity in China, according to children's ages and regional differences. METHODS: Based on individual food consumption data from the China Health and Nutrition Survey (CHNS) package in 2011, cross-sectional studies have previously been conducted to analyse the association between different categories of food intake of parents and children. The current study extends this research by directly. RESULTS: Our analysis results show that parental food intake is highly correlated with children's food intake, with the estimated coefficients of most food intake categories being greater than 0.5. Furthermore, this association between parental food intake and children's overweight and obesity is most significant in young children, but it begins to weaken in relation to children aged between 13 and 18. Additionally, the associations between parental food intake and children's overnutrition are more significant in rural areas than they are in urban areas. CONCLUSIONS: The association between parental food intake and childhood overweight and obesity is significant, although it varies considerably according to food categories, children's ages and area differences. These results show promise for intervening in the overnutrition of children by controlling household dietary patterns according to children's developmental stages and regional differences.

Use of Cumulative Live Birth Rate per Total Number of Embryos to Calculate the Success of IVF in Consecutive IVF Cycles in Women Aged ≥35 Years.

OBJECTIVE: The use of cumulative live birth rate (CLBR) per ovarian stimulation cycle is proving to be an accurate method to calculate the success of IVF; however, the cycle outcome is closely associated with the number of embryos transferred (ET). Our aim was to report CLBR after IVF according to the number of embryos required to achieve a live birth in women aged ≥35 years, considering age, body mass index (BMI), and ethnicity. METHODS: We conducted a retrospective cohort study including 1344 patients who underwent IVF between January 2013 and June 2016 at the First Affiliated Hospital of Xinjiang Medical University. The cumulative probability of live birth for each couple was estimated using the Kaplan-Meier method, and survival curves were compared according to age, BMI, and ethnicity using the log-rank test. RESULTS: CLBR increased rapidly from 1 to 5 ETs, moderately from 6 to 10 ETs, and slowly thereafter. CLBR was significantly different across 4 categories based on BMI as well as across those based on age; low CLBR was significantly associated with the age of ≥42 years and obesity. CONCLUSION: The association between CLBR and number of ET provides realistic and precise information regarding the success of IVF and can be applied to guide clinicians and patients.

Synthesis and characterization of grafting polystyrene from guar gum using atom transfer radical addition.

To broaden the application fields for guar gum, this natural polymer is often grafted to/from the surface to modify its properties. Polystyrene-guar gum (PS-guar gum) is successfully synthesized using atom transfer radical addition based n-BuBr(C4H9Br), Cu(I)Cl and N,N,N',N″,N‴-penthamethyldiethylenetriamine (C9H23N3,PMDETA) as initiator, electronating agent and ligand respectively in an inert atmosphere. The graft copolymer is characterized by FT-IR, 1H NMR, XRD and scanning electron microscope (SEM). The results show that styrene is successfully introduced onto guar gum and particles of PS-guar gum adopt a disordered morphology with diameters of 100nm, and PS-guar gum are largely amorphous with poor crystallinity. Besides, add on shows an increasing trend on increasing the concentration of PS. Swelling behavior, hydrophobicity and thermal stability of PS-guar gum indicate that PS-guar gum has great thickening capacity and thermal stability. Nevertheless, modification of guar gum via ATRA truly is convenient to industrial production since facilitating the manufacturing process.

Alarming and increasing prevalence of multidrug-resistant Pseudomonas aeruginosa among healthcare-associated infections in China: A meta-analysis of cross-sectional studies.

A number of studies have reported on the prevalence of multidrug-resistant Pseudomonas aeruginosa (MDR-PA) among healthcare-associated infections (HAIs) in China; however, the exact rate of MDR-PA is unclear due to different definitions. Therefore, this meta-analysis was conducted to explore the prevalence of MDR-PA among HAIs in China based on an international recommended standard. Medline, Ovid, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Wanfang databases were systematically searched and papers published before February 2014 providing exact data on MDR-PA in the Chinese population were identified. Overall effects, subgroup analysis and sensitivity analysis were performed using Stata v.13.0 software. Twenty-six studies were finally included. The overall prevalence of MDR-PA was 29.0% (95% confidence interval 24.6-33.4%). The rate of MDR-PA increased over time (P<0.001). The prevalence of MDR-PA was higher among patients in intensive care units (ICUs) (41.4%) than among non-ICU patients (24.1%) (P<0.001). In conclusion, the present meta-analysis comprehensively evaluated the prevalence of MDR PA in China and the findings suggest that MDR-PA should receive more attention.

Determination of Polychlorinated Dibenzo-p-dioxins/Dibenzofurans, Dioxin Like Polychlorinated Biphenyls, Brominated Flame Retardants and Polybrominated Dibenzo-p-dioxins/Dibenzofurans in Flue Gas from Stationary Source / 分析化学

A method for simultaneous determination of PCDDs, dl-PCBs, BFRs and PBDD/Fs in flue gas from stationary source was developed. The sample was extracted by Soxhlet apparatus with toluene, and followed by purification through sulfuric acid partition and multi-layer silica gel column separation. The target compounds were then all separated by passing through the active carbon-dispersed silica gel column and reversal eluting. Gas chromatography coupled with a thermostable capillary column ( short length, thin stationary phase film) was operated at pulse injection mode. High resolution mass spectrometry set at low-electron-energy ionization was used for quantification. The high- and low-brominated compounds were determined simultaneously. The detection limits of this method were 0. 081-1. 2 pg for PCDD/Fs, 0. 10-0. 32 pg for dl-PCBs, 0. 14-12 pg for PBDEs, 0. 26-16 pg for new BFRs, 0. 44-3. 6 pg for tetra- to hepta-BDD/Fs and 8. 2-12 pg for OBDD/F. Recoveries ( RSDs) in spiked flue gas samples were 88%-115%(2. 9%-6. 1%) for PCDD/Fs, 84%-118% (3. 2%-10%) for dl-PCBs, 71%-135% (2. 1%-18%) for PBDEs, 71%-114% (2. 9%-7. 4%) for new BFRs, 83%-127% (5. 2%-10%) for tetra-to hepta-BDD/Fs and 52%-149% ( 23%-24%) for OBDD/F. All quality control data fell within the acceptable range specified in analysis standards for flue gas.

XRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controls.

BACKGROUND: In the X-ray repair cross-complementing group 1 (XRCC1) gene, a polymorphism, Arg399Gln (rs25487), has been shown to change neoconservative amino acid and thus result in alternation of DNA repair capacity. Numerous studies have investigated the association between Arg399Gln and breast cancer risk in the American population, but yielding inconsistent results. This study aimed to clarify the role of this polymorphism in susceptibility to breast cancer. METHODS: Literatures were searched in multiple databases including PubMed, Springer Link, Ovid, EBSCO and ScienceDirect databases up to April 2013. A comprehensive meta-analysis was conducted to estimate the overall odds ratio (OR), by integrating data from 18 case control studies of 10846 cases and 11723 controls in the American population. RESULTS: Overall, significant association was observed between the Arg399Gln polymorphism and breast cancer risk under the random-effects model (OR for dominant model = 1.12, 95% CI: 1.02-1.24, P heterogeneity = 0.003; OR for additive model = 1.07, 95% CI: 1.01-1.14, P heterogeneity = 0.017). Further sensitivity analysis supported the robust stability of this current result by showing similar ORs before and after removal of a single study. CONCLUSIONS: This meta-analysis suggests that the XRCC1 Arg399Gln polymorphism may significantly contribute to susceptibility of breast cancer in the American population.

Teicoplanin as an effective alternative to vancomycin for treatment of MRSA infection in Chinese population: a meta-analysis of randomized controlled trials.

OBJECTIVE: To evaluate whether teicoplanin could be an alternative to vancomycin for treatment of MRSA infection in Chinese population using a meta-analysis in randomized controlled trials. METHODS: THE FOLLOWING DATABASES WERE SEARCHED: Chinese Biomedical Literature database (CBM), Chinese Journal Full-text database (CNKI), Wanfang database, Medline database, Ovid database and Cochrane Library. Articles published from 2002 to 2013 that studied teicoplanin in comparison to vancomycin in the treatment of MRSA infected patients were collected. Overall effects, publishing bias analysis and sensitivity analysis on clinical cure rate, microbiologic eradication rate and adverse events rate were performed by using Review Manager 5.2 and Stata 11.0 softwares. RESULTS: Twelve articles met entry criteria. There was no statistically significant difference between the two groups regarding the clinical cure rate (risk ratio [RR], teicoplanin vs vancomycin, 0.94; 95% CI, 0.74~1.19; P=0.60), microbiological cure rate (risk ratio [RR], teicoplanin vs vancomycin, 0.99; 95% CI, 0.91~1.07; P=0.74) and adverse event rate (risk ratio [RR], teicoplanin vs vancomycin, 0.86; 95% CI, 0.40~1.84; P=0.70). CONCLUSIONS: The meta-analysis results indicate that the two therapies are similar in both efficacy and safety, thus teicoplanin can act as an effective alternative to vancomycin for treating patients infected by MRSA.

[Effect of UV-B radiation on the chemical composition and subsequent decomposition of Cyclobalanopsis glauca leaf litter].

A experiment on leaf litter decomposition was carried out to evaluate the effects of UV-B radiation on the chemical composition and subsequent decomposition of leaf litter in humid subtropical forest systems. The leaf litter was derived from Cyclobalanopsis glauca seedlings exposed to elevated and ambient ultraviolet B (UV-B) radiation treatments during growth for one year. The results showed that UV-B treatment significantly increased the original N, K and P content of leaf litter by 154.9%, 29.8% and 9.7%, respectively, and decreased the ratios of C: N, lignin: N and C: P of leaf litter by 60.5%, 61.7% and 8.5%, respectively (P < 0.05), but had no significant effect on C and lignin content. The decomposition of leaf litter derived from seedlings exposed to elevated UV-B treatment during growth was faster, but did not show significant difference from that of ambient UV-B treatment. Exposure to elevated UV-B radiation during growth did not significantly influence the K release, but promoted the P release and retarded the N accumulation during leaf litter decomposition. Our result will contribute to the better understanding of the role of UV-B radiation in moist subtropical forest ecosystem.