ABSTRACT
We report a case of double aneuploidy in a preterm male newborn with karyotype 48,XXY,+18 whose mother was of advanced age and infected with the SARS-CoV-2 virus during the early stages of her pregnancy. The clinical features observed in the newborn included intrauterine growth retardation, dysmorphic facial features, overlapping fingers on both hands, respiratory distress syndrome, ventricular septal defect, patent ductus arteriosus, persistent pulmonary hypertension, and bilateral clubfoot, a phenotype that mainly correlates with Edwards syndrome (trisomy 18). To our knowledge, this is the first reported case of double aneuploidy in Croatia. This paper provides a detailed description of the clinical presentation and treatment strategies used, with the aim of providing valuable data for future recognition and management of similar cases. Furthermore, we discuss the mechanisms of nondisjunction that might account for this rare form of aneuploidy.
Subject(s)
COVID-19 , Male , Female , Pregnancy , Humans , Trisomy 18 Syndrome/complications , COVID-19/complications , Croatia , SARS-CoV-2 , AneuploidyABSTRACT
PURPOSE: The aim of the study was to assess perinatal outcome of pregnancy burdened with maternal addiction in comparison with an unselected population from a European transition country. MATERIALS AND METHODS: Data on pregnancies complicated by illicit drug abuse (n = 85) managed during a 10-year period (1997-2007) at Split University Hospital were analyzed. Data on the type of drug, course of gestation and labor, and on perinatal outcome were considered. Data on all non-dependence pregnancies recorded during the study period were used as a control group. RESULTS: During the study period, there were 85 dependence-complicated pregnancies (0.2%). Use of heroin alone during pregnancy was recorded in 51 women (50%), methadone alone in 6 (7%), and a combination of heroin and methadone in 9 (11%). Premature delivery was significantly more common in the group of pregnant addicts (21% vs. 6%); 49% of pregnant addicts were carriers of hepatitis C virus (HCV) and 14% of hepatitis B virus (HBV). Neonatal abstinence syndrome developed in 61 infants (7%) born to addicted mothers. There were 4 cases (4.6%) of early neonatal death; 7 neonates had 5-minute Apgar score < or = 7 (8%); 29 neonates had low birth weight for age (33%); and 7 neonates had congenital anomalies (8%). The risk of various congenital anomalies was 3-fold in the group of children born to addicted mothers. CONCLUSION: Addiction pregnancies present a small but high-risk group according to perinatal outcome. Appropriate obstetric and neonatal care can reduce the rate of complications in these pregnancies and improve perinatal outcome.
Subject(s)
Heroin Dependence/complications , Maternal Exposure , Pregnancy Complications/chemically induced , Pregnancy Outcome , Adult , Apgar Score , Birth Weight , Croatia/epidemiology , Female , Heroin/adverse effects , Heroin Dependence/drug therapy , Heroin Dependence/epidemiology , Humans , Incidence , Infant Mortality , Infant, Newborn , Methadone/adverse effects , Methadone/therapeutic use , Neonatal Abstinence Syndrome/epidemiology , Pregnancy , Pregnancy Complications/epidemiology , Pregnancy Complications, Infectious/epidemiologyABSTRACT
The aim of the study was to determine the incidence of strabismus in preterm infants born between 2002 and 2005 in Split-Dalmatia County, and to compare it with term infants. Data were collected from Department of Public Health, Split-Dalmatia County and Strabology Outpatient Department, University Department of Ophthalmology, Split University Hospital Center. Strabismus was present in 796 (3.97%) children born between 2002 and 2005. Strabismus was diagnosed in 1.37% of term infants and 17.57% of preterm infants. Various factors can produce disorders in preterm infants, such as diffuse and focal defects of the white brain matter, and disorders of oligodendroglial cells, which may explain the higher incidence of strabismus in preterm infants as compared with term infants.
