ABSTRACT
The novel HLA-C allele HLA-C*12:365 identified in an individual from the Gujarati population.
Subject(s)
Genes, MHC Class I , HLA-C Antigens , Humans , Alleles , IndiaABSTRACT
The novel HLA-A allele HLA-A*02:01:209 sequence identified in a solid organ recipient.
Subject(s)
HLA Antigens , High-Throughput Nucleotide Sequencing , Humans , HLA Antigens/genetics , Sequence Analysis, DNA , Alleles , Histocompatibility Testing , Genomics , HLA-A Antigens/geneticsABSTRACT
The full-length genomic sequence of the HLA-DRB1*13:129 allele was identified in a donor of Gujarati population.
Subject(s)
HLA-DRB1 Chains , Humans , HLA-DRB1 Chains/genetics , AllelesABSTRACT
Autoimmunity eventuates when the immune system attacks self-molecules as a result of the breakdown in immune tolerance. Targeting autoimmune diseases via immunomodulation has become an essential strategy in today's era. A B7 superfamily member immune checkpoint, the V-set domain containing T-cell activation inhibitor-1 (VTCN1), also known as B7-H4, B7S1, and B7x, is involved in negatively regulating T-cell activation. VTCN1 transcript has been reported in various lymphoid and non-lymphoid tissues, but its protein expression is restricted, indicating its translational regulation. Dysregulation of VTCN1 has resulted in the exacerbation of various autoimmune diseases. Moreover, increased soluble form of VTCN1 in the patient's sera positively correlates with the disease progression and severity. The current review summarizes all the reports till date, unfolding the role of VTCN1 in various autoimmune diseases and its therapeutic potential.
Subject(s)
Autoimmune Diseases , V-Set Domain-Containing T-Cell Activation Inhibitor 1 , Humans , Autoimmune Diseases/therapy , Autoimmune Diseases/metabolism , Autoimmunity , Lymphocyte Activation , T-Lymphocytes , V-Set Domain-Containing T-Cell Activation Inhibitor 1/metabolismABSTRACT
The extended genomic sequences of HLA-DRB1*14:04:07 and -DRB1*15:53 alleles were identified in the Gujarati individuals.
Subject(s)
Genomics , High-Throughput Nucleotide Sequencing , Humans , HLA-DRB1 Chains/genetics , Alleles , Histocompatibility TestingABSTRACT
The full length sequences of the HLA-DRB1*07:03 and HLA-DRB1*12:69 alleles identified in transplant donors.
Subject(s)
Genomics , Tissue Donors , Alleles , HLA-DRB1 Chains/genetics , High-Throughput Nucleotide Sequencing , HumansABSTRACT
The full length sequence of HLA-B*15:01:02 and HLA-C*08:72:01 are reported.
