Impact of age on the outcomes of women following percutaneous coronary intervention in the bare-metal stent era.

AIM: Advanced age and female gender are both independent predictors of early and late mortality and adverse cardiac outcomes for patients undergoing balloon angioplasty. Elderly women are at particular risk. Stenting is now the standard of care in PCI. Whether elderly women remain at increased risk after PCI in the current stent era has not been examined widely. METHODS: Prospective data were collected in 400 consecutive female patients undergoing PCI at a tertiary cardiac center (1999-2003). Follow-up was done at 1 month, 6 months, and 12 months by clinic visits, telephonic interviews, and reviewing hospital records. Follow-up was complete in 396 patients. RESULTS: Compared to young women (<65 years old), elderly women (>65 years old) were less likely to smoke (15.7% vs 47.2%, P = 0.001), less likely to have diabetes (4.1% vs 8.5%, P = 0.05), and had more multivessel coronary artery disease. Usage of stent was high, similar in both groups. Hypertension, hypercholesterolemia, previous MI, vessels treated, abciximab usage, and access site bleeding were similar in both groups. Procedural success (96% vs 98%) and in-hospital and 1-year MACE (23.1% vs 25%) are similar in both groups. CONCLUSION: Elderly women undergoing PCI have a distinct profile presenting with more multivessel disease, less smoking, and are less likely to have diabetes than younger women. In the current stent era, procedural success, in-hospital adverse cardiac events, and MACE at 1 year are similar in both groups. At 1 year, however, elderly women are less likely to have ischemia-driven TVR and recurrence of angina.

Pulmonary artery sarcoma--a challenging diagnosis: a case report.

Pulmonary artery sarcoma is a known but rare tumor with poor prognosis. It is a challenging diagnostic dilemma, as the main complaint of these patients is progressive dyspnea. Dyspnea is a common symptom in cardiorespiratory disease and therefore a high index of suspicion is necessary to make the diagnosis early and proceed with surgery and radiotherapy and/or chemotherapy. We report a case of primary pulmonary artery sarcoma that presented initially with weight loss, shortness of breath, palpitations, and dysphagia.

Left ventricular systolic dysfunction and atrial fibrillation in older people in the community--a need for screening?

BACKGROUND: Heart failure and stroke are major causes of morbidity and mortality in older people. Angiotensin converting enzyme inhibitors improve symptoms and survival in left ventricular systolic dysfunction. Anticoagulants are effective in stroke prevention in atrial fibrillation with aspirin being a less effective alternative. OBJECTIVES: To determine the prevalence of left ventricular systolic dysfunction, health services utilisation and prescribing of diuretics and angiotensin converting enzyme inhibitors in left ventricular systolic dysfunction, and the prevalence of atrial fibrillation and anti-platelet/thrombotic therapy in atrial fibrillation in older people in the community. METHODS: 500 subjects were drawn by two-stage random sampling from 5,002 subjects aged 70 years and over living at home. Subjects were screened for atrial fibrillation and left ventricular systolic dysfunction using electrocardiography and echocardiography. RESULTS: The population prevalence amongst older people of left ventricular systolic dysfunction was 9.8% and of atrial fibrillation 7.8%. More than two-thirds of those with left ventricular systolic dysfunction were not on angiotensin converting enzyme inhibitors. Of those in atrial fibrillation, 35% were taking aspirin, 24% were taking warfarin and 41% were on neither aspirin nor warfarin. Nearly 90% of older people in the community have had contact with their general practitioner over the past year, and over half of those with left ventricular systolic dysfunction have had contact with hospital-based services over the past 2 years. CONCLUSIONS: Left ventricular systolic dysfunction is under-treated in older people in the community. Despite the high level of contact with hospital and community-based services, the majority of those with systolic left ventricular dysfunction are not on angiotensin converting enzyme inhibitors and a significant proportion of those in atrial fibrillation are not on any treatment for stroke prevention.

European reference values for Doppler indices of left ventricular diastolic filling.

The European Study Group on diastolic heart failure requires objective evidence of abnormal left ventricular diastolic function to establish the diagnosis of diastolic heart failure, which is common in older people. Reference values for Doppler indices of transmitral flow, used to assess left ventricular diastolic function, have not been reported for people 70 years and over in Europe. The aim of this study was to establish reference values for these Doppler indices of transmitral flow in older people. A random sample of 355 subjects aged 70 and over, living in the community underwent clinical assessment and echocardiography. Asymptomatic subjects with no cardiovascular disease and cardiovascular risk factors were identified. Measurements of five commonly used Doppler indices of transmitral flow from these subjects were obtained and reference range expressed as mean+/-2 standard deviations and as percentiles. We have therefore generated reference Doppler values of transmitral flow for people aged over 70 in a British population.

Diastolic heart failure in older people.

OBJECTIVES: To determine the prevalence of diastolic heart failure in older people in the community, identify associated risk factors and measure its impact on function and quality of life. DESIGN: Cross-sectional population-based study. METHODS: A two-stage random sample of 500 subjects was drawn from 5,002 subjects aged 70 years and over living at home. Diastolic heart failure was diagnosed by a panel of three physicians, based on clinical assessment and echocardiographic indicators of diastolic dysfunction. MAIN OUTCOME MEASURES: Prevalence of diastolic heart failure and its effect on function and quality of life as measured by Nottingham Extended Activities of Daily Living, Hospital Anxiety and Depression and SF-36 questionnaires. RESULTS: The prevalence of diastolic heart failure was 5.54% (95% CI = 3.71, 7.87) and was higher in women (8.32%) than in men (1.25%), P = 0.008. On multivariate analysis of variance, diastolic heart failure was associated with female gender and history of ischaemic heart disease. Subjects with diastolic heart failure had significantly poorer functional status and physical health than those without heart failure. CONCLUSIONS: Diastolic heart failure is relatively common in older people and is associated with adverse affects in older people's lives.

Abnormal myocardial strain rate in noncompaction of the left ventricle.

A 28-year-old woman presented in the second trimester of pregnancy with palpitations and left heart failure. Transthoracic echocardiography showed features consistent with isolated noncompaction of the left ventricle. Doppler tissue echocardiography with strain-rate imaging revealed unique appearances of paradoxical alternating bands of compression and expansion throughout systole and diastole. These features may be pathognomonic for this disease.