ABSTRACT
OBJECTIVE: To investigate the efficacy and safety of imiquimod 5% cream in the treatment of anogenital warts in a female population. METHODS: In two open-label studies, female patients with anogenital warts applied imiquimod 5% cream three times a week for up to 16 weeks. Patients who cleared their warts were monitored for a 6-month follow-up period. Patients could be re-treated with imiquimod 5% cream for up to an additional 16 weeks if their warts recurred or new warts developed during the follow-up period. The treatment period could also be extended for up to an additional 16 weeks if patients only experienced partial clearance during the initial 16-week treatment period. RESULTS: Of the female patients who applied imiquimod 5% cream, 75% (449/600) experienced complete clearance of their warts (treatment failure analysis). This includes 46 patients who experienced total clearance when they applied imiquimod for longer than 16 weeks as their warts had only partially cleared in the initial 16 weeks of therapy. During the 6 months of follow-up after the initial treatment period, 15% of patients had recurrent warts. Thirty-nine (75%) of those patients experienced total clearance again after they re-applied imiquimod for up to an additional 16 weeks. The most frequently observed local skin reaction was erythema. CONCLUSION: In these studies, imiquimod 5% cream was an effective and well-tolerated treatment for anogenital warts in females and continued to be safe and effective in the small proportion of patients who needed to re-apply imiquimod after wart recurrence.
Subject(s)
Aminoquinolines/administration & dosage , Condylomata Acuminata/drug therapy , Adult , Drug Administration Schedule , Female , Follow-Up Studies , Humans , Imiquimod , Ointments/administration & dosage , Recurrence , Treatment Outcome , Vaginal Creams, Foams, and JelliesABSTRACT
We describe two patients with cutaneous myiasis caused by Dermatobia hominis. Three larvae were removed successfully by a simple technique that involved the injection of each larva with 2 mL of lidocaine, making surgical extraction by incision and exploration unnecessary.
Subject(s)
Foot Dermatoses/therapy , Myiasis/therapy , Scalp Dermatoses/therapy , Skin Diseases, Parasitic/therapy , Adult , Female , Foot Dermatoses/parasitology , Humans , Male , Myiasis/parasitology , Scalp Dermatoses/parasitology , Skin Diseases, Parasitic/parasitologyABSTRACT
Twenty-one married couples, recruited from childbirth classes (mean age 29.6 years), were administered questionnaires measuring 20 different moods during the third trimester of pregnancy (prepartum period), during the postpartum period, and at 6 months after birth (follow-up period). In each questionnaire period individual questionnaires were filled out daily by both the mother and father for 10 consecutive days. The results indicated that the postpartum period, compared with the prepartum and follow-up periods, is an emotionally unique time but not a period marked by depression. The moods that were rated as being experienced more strongly by men and women during the postpartum period were associated with anxiety and concern for one's ability to cope such as "nervousness," "worried," "helpless," and "anxious" or positive emotions such as "enthusiastic" and "happy." It is concluded that men and women in this sample tend to experience the postpartum period in an emotionally similar way.
Subject(s)
Emotions , Parents/psychology , Postpartum Period , Adult , Affect , Anxiety , Attitude , Depression/epidemiology , Female , Humans , Male , Middle Aged , Pregnancy , Puerperal Disorders/epidemiology , Surveys and Questionnaires , Time FactorsABSTRACT
Five individuals developed striate bullous dermatitis two days after exposure on a clear day to Heracleum mantegazzianum, Umbelliferae (Parsnip) family. Photopatch testing confirmed phototoxicity from the plant. This and 28 other Heracleum species yield linear furanocoumarins.
