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1.
Connective tissue diseases: New low disease activity target defined in SLE.
Buckland, Jenny.
Nat Rev Rheumatol ; 11(12): 682, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26502798

Subject(s)
Immunosuppressive Agents/administration & dosage , Lupus Erythematosus, Systemic/drug therapy , Maintenance Chemotherapy/standards , Severity of Illness Index , Steroids/administration & dosage , Consolidation Chemotherapy , Humans , Lupus Erythematosus, Systemic/prevention & control
2.
Osteoarthritis: Genetically modified ADSCs as cell therapy for OA?
Buckland, Jenny.
Nat Rev Rheumatol ; 11(11): 622, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26416597
3.
Connective tissue diseases. Skin gene expression profiles in SSc.
Buckland, Jenny.
Nat Rev Rheumatol ; 11(10): 563, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26282083

Subject(s)
Fibroblasts/metabolism , Gene Expression , Scleroderma, Diffuse/pathology , Scleroderma, Systemic/genetics , Skin/metabolism , Skin/pathology , Thrombospondin 1 , Female , Humans , Male
4.
Rheumatoid arthritis: First-in-human phase I trial of DC immunotherapy for early RA.
Buckland, Jenny.
Nat Rev Rheumatol ; 11(8): 443, 2015 Aug.
Article in English | MEDLINE | ID: mdl-26100972

Subject(s)
Arthritis, Rheumatoid/therapy , Citrulline/chemistry , Dendritic Cells/immunology , HLA Antigens/genetics , Immunotherapy , Peptides/chemistry , Female , Humans , Male
5.
Experimental arthritis: Antiviral IFN-λ2 has unexpected roles in inflammation.
Buckland, Jenny.
Nat Rev Rheumatol ; 11(7): 383, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25986719

Subject(s)
Gene Expression Regulation , Inflammation/metabolism , Interleukin-1beta/metabolism , Interleukins/pharmacology , Animals , Male
6.
Experimental arthritis: in vivo noninvasive molecular optical imaging of disease.
Buckland, Jenny.
Nat Rev Rheumatol ; 11(5): 258, 2015 May.
Article in English | MEDLINE | ID: mdl-25800213

Subject(s)
Arthritis, Experimental/diagnosis , Carboxy-Lyases , Diagnostic Imaging/methods , Spectroscopy, Near-Infrared/methods , Animals , Male
7.
Musculoskeletal biology and bioengineering. Growth plate or articular: whatever your cartilage type, thyroid hormones are in control!
Buckland, Jenny.
Nat Rev Rheumatol ; 11(4): 198, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25734974

Subject(s)
Biomechanical Phenomena/physiology , Cartilage, Articular/physiology , Chondrocytes/drug effects , Parathyroid Hormone/pharmacology , Thyroxine/pharmacology , Triiodothyronine/pharmacology , Animals
8.
Bone: Anabolic Wnt/ß-catenin signalling: osteocytes are key.
Buckland, Jenny.
Nat Rev Rheumatol ; 11(3): 128, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25668138

Subject(s)
Bone and Bones/metabolism , Osteocytes/physiology , Wnt Signaling Pathway , beta Catenin/metabolism , Animals
9.
Osteoarthritis: MicroRNA-mediated meniscal injury repair in rats.
Buckland, Jenny.
Nat Rev Rheumatol ; 11(2): 64, 2015 Feb.
Article in English | MEDLINE | ID: mdl-25512009

Subject(s)
Cartilage, Articular/pathology , MicroRNAs/therapeutic use , Animals , Injections, Intra-Articular , Rats , Rupture , Wound Healing
10.
Rheumatoid arthritis: Anti-TNF and anti-IL-17 antibodies--better together!
Buckland, Jenny.
Nat Rev Rheumatol ; 10(12): 699, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25348041

Subject(s)
Antibodies, Bispecific/therapeutic use , Antirheumatic Agents/therapeutic use , Arthritis, Rheumatoid/drug therapy , Interleukin-17/antagonists & inhibitors , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Animals , Humans
11.
Rheumatoid arthritis: TNF targets histones to loosen chromatin in RA FLS.
Buckland, Jenny.
Nat Rev Rheumatol ; 10(11): 636, 2014 Nov.
Article in English | MEDLINE | ID: mdl-25247409

Subject(s)
Arthritis, Rheumatoid/immunology , Chromatin/metabolism , Fibroblasts/metabolism , Histones/metabolism , Synovial Membrane/cytology , Tumor Necrosis Factor-alpha/immunology , Acetylation , Arthritis, Rheumatoid/genetics , Arthritis, Rheumatoid/metabolism , Chemokine CXCL10/genetics , Chemokine CXCL10/immunology , Chemokine CXCL11/genetics , Chemokine CXCL11/immunology , Chemokine CXCL9/genetics , Chemokine CXCL9/immunology , Epigenesis, Genetic , Humans , Tumor Necrosis Factor-alpha/metabolism
12.
Osteoimmunology: dual role for Wnt4: bone formation and bone resorption.
Buckland, Jenny.
Nat Rev Rheumatol ; 10(10): 575, 2014 Oct.
Article in English | MEDLINE | ID: mdl-25155580

Subject(s)
Bone and Bones/physiology , Inflammation/metabolism , NF-kappa B/metabolism , Signal Transduction , Wnt4 Protein/metabolism , Animals
13.
Rheumatoid arthritis: citrullination alters the inflammatory properties of chemokines in inflammatory arthritis.
Buckland, Jenny.
Nat Rev Rheumatol ; 10(8): 446, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25003766

Subject(s)
Arthritis, Rheumatoid/metabolism , Chemokine CXCL5/metabolism , Monocytes/metabolism , Synovial Fluid/metabolism , Animals , Female , Humans , Male
14.
Experimental arthritis: Fire and ice: syndecan-3 in inflammation.
Buckland, Jenny.
Nat Rev Rheumatol ; 10(9): 514, 2014 Sep.
Article in English | MEDLINE | ID: mdl-25072265

Subject(s)
Arthritis, Experimental/immunology , Arthritis, Rheumatoid/immunology , Syndecan-3/immunology , Animals
15.
Osteoarthritis: Epigenetic clues into the molecular basis of OA.
Buckland, Jenny.
Nat Rev Rheumatol ; 10(7): 383, 2014 Jul.
Article in English | MEDLINE | ID: mdl-24890775

Subject(s)
Cartilage, Articular/metabolism , DNA Methylation , Osteoarthritis, Hip/metabolism , Osteoarthritis, Knee/metabolism , Female , Humans , Male
16.
Crystal arthropathies: The NET is closing in on inflammation in gout.
Buckland, Jenny.
Nat Rev Rheumatol ; 10(6): 319, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24818672

Subject(s)
Chemokines/metabolism , Cytokines/metabolism , Gout/metabolism , Inflammation/metabolism , Neutrophils/metabolism , Animals , Humans
17.
Rheumatoid arthritis: ETA and MTX versus MTX alone in early inflammatory arthritis.
Buckland, Jenny.
Nat Rev Rheumatol ; 10(5): 258, 2014 May.
Article in English | MEDLINE | ID: mdl-24686508

Subject(s)
Antirheumatic Agents/therapeutic use , Arthritis/drug therapy , Immunoglobulin G/therapeutic use , Methotrexate/therapeutic use , Receptors, Tumor Necrosis Factor/therapeutic use , Synovitis/drug therapy , Female , Humans , Male
18.
Osteoarthritis: blocking cartilage damage in a rat model of OA by intra-articular injection of an amniotic membrane allograft.
Buckland, Jenny.
Nat Rev Rheumatol ; 10(4): 198, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24567058

Subject(s)
Amnion , Anti-Inflammatory Agents/administration & dosage , Arthritis, Experimental/drug therapy , Chorion , Osteoarthritis/pathology , Animals , Humans , Male
19.
Connective tissue diseases: Role for T cell lipid metabolism defects in SLE pathogenesis.
Buckland, Jenny.
Nat Rev Rheumatol ; 10(3): 127, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24514916

Subject(s)
CD4-Positive T-Lymphocytes/cytology , Gene Expression Regulation , Glycosphingolipids/physiology , Lupus Erythematosus, Systemic/blood , Lupus Erythematosus, Systemic/immunology , Female , Humans , Male
20.
Inflammatory myopathies. Understanding the link between chronic inflammation and muscle degeneration in myositis.
Buckland, Jenny.
Nat Rev Rheumatol ; 10(2): 65, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24342983

Subject(s)
Myositis/immunology , Animals , Cell Line , Chronic Disease , Humans , Inflammation , Mice , MicroRNAs/analysis , MicroRNAs/biosynthesis , Muscle, Skeletal/chemistry , Muscle, Skeletal/immunology , Muscular Atrophy/immunology , Tumor Necrosis Factor-alpha/analysis , Tumor Necrosis Factor-alpha/biosynthesis
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