Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 33
Filter
1.
Article in English | MEDLINE | ID: mdl-39003121

ABSTRACT

The average post-pandemic modern radiology practice is experiencing an ever-increasing workload volume with overall relatively similar staffing levels, regardless of practice setting. This has resulted in an increased workload demand for the average diagnostic radiologist, which in many cases translates to longer working hours. It is now more important than ever to be cognizant of various work-related injuries, including repetitive-stress injuries and vision-related ailments as examples, in relation to the working conditions of the radiologist. This article will discuss commonly occurring conditions and ergonomic considerations that the radiologist can employ to reduce the risk of work-related injuries.

2.
Acad Radiol ; 31(4): 1262-1264, 2024 04.
Article in English | MEDLINE | ID: mdl-38458888
3.
J Digit Imaging ; 34(1): 1-15, 2021 02.
Article in English | MEDLINE | ID: mdl-33481143

ABSTRACT

In order for enterprise imaging to be successful across a multitude of specialties, systems, and sites, standards are essential to categorize and classify imaging data. The HIMSS-SIIM Enterprise Imaging Community believes that the Digital Imaging Communications in Medicine (DICOM) Anatomic Region Sequence, or its equivalent in other data standards, is a vital data element for this role, when populated with standard coded values. We believe that labeling images with standard Anatomic Region Sequence codes will enhance the user's ability to consume data, facilitate interoperability, and allow greater control of privacy. Image consumption-when a user views a patient's images, he or she often wants to see relevant comparison images of the same lesion or anatomic region for the same patient automatically presented. Relevant comparison images may have been acquired from a variety of modalities and specialties. The Anatomic Region Sequence data element provides a basis to allow for efficient comparison in both instances. Interoperability-as patients move between health care systems, it is important to minimize friction for data transfer. Health care providers and facilities need to be able to consume and review the increasingly large and complex volume of data efficiently. The use of Anatomic Region Sequence, or its equivalent, populated with standard values enables seamless interoperability of imaging data regardless of whether images are used within a site or across different sites and systems. Privacy-as more visible light photographs are integrated into electronic systems, it becomes apparent that some images may need to be sequestered. Although additional work is needed to protect sensitive images, standard coded values in Anatomic Region Sequence support the identification of potentially sensitive images, enable facilities to create access control policies, and can be used as an interim surrogate for more sophisticated rule-based or attribute-based access control mechanisms. To satisfy such use cases, the HIMSS-SIIM Enterprise Imaging Community encourages the use of a pre-existing body part ontology. Through this white paper, we will identify potential challenges in employing this standard and provide potential solutions for these challenges.


Subject(s)
Electronic Health Records , Medicine , Diagnostic Imaging , Human Body , Humans
5.
Radiographics ; 32(4): 1089-107, 2012.
Article in English | MEDLINE | ID: mdl-22786996

ABSTRACT

Multidetector computed tomography (CT) is an excellent way to supplement the radiographic evaluation of problematic hip prostheses. Multidetector CT is well suited for assessing periprosthetic bone, determining precise acetabular cup position, and evaluating periprosthetic fluid collections or ossified masses. Metal implants pose a number of challenges in the performance and interpretation of CT examinations. However, metal artifacts can be minimized by decreasing the detector collimation and pitch, increasing the kilovolt peak and milliampere-seconds, and using appropriate reconstruction algorithms and section thickness. Image interpretation requires a basic understanding of hip reconstruction and hip implants, as well as use of a systematic method of analysis that incorporates prior radiographic findings and CT findings. Radiologists must be familiar with the normal and abnormal CT appearances of hip prostheses and be able to recognize common complications on CT scans.


Subject(s)
Artifacts , Hip Joint/diagnostic imaging , Hip Prosthesis/adverse effects , Joint Instability/diagnostic imaging , Prosthesis-Related Infections/diagnostic imaging , Prosthesis-Related Infections/etiology , Tomography, X-Ray Computed/methods , Hip Joint/surgery , Humans , Joint Instability/etiology , Metals , Radiographic Image Enhancement/methods
6.
AJR Am J Roentgenol ; 198(6): W602-4, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22623577

ABSTRACT

OBJECTIVE: T2 relaxation time is sensitive in detecting early cartilage damage. There are few reports of T2 mapping for smaller joints because of technical challenges. The purpose of this study is to evaluate the feasibility of T2 mapping of the metacarpal head cartilage in children. CONCLUSION: T2 mapping of the metacarpal head cartilage is feasible in children on a 3-T scanner with commercially available coils. An increase in the T2 values near the osteochondral junction likely reflects the secondary physis.


Subject(s)
Cartilage/pathology , Magnetic Resonance Imaging/methods , Metacarpal Bones/pathology , Analysis of Variance , Child , Female , Humans , Image Interpretation, Computer-Assisted , Magnetic Resonance Imaging/instrumentation , Male , Prospective Studies , Software
7.
Semin Musculoskelet Radiol ; 15(4): 309-19, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21928156

ABSTRACT

Orthopedic hardware should not be considered a contraindication to computed tomography (CT) or magnetic resonance (MR) imaging. The hardware alloy, the geometry of the hardware, and the orientation of the hardware all affect the magnitude of image artifacts. For commonly encountered alloys, the severity of image artifacts is similar for CT and MR. Cobalt chrome or stainless steel hardware produces the most artifacts; titanium hardware produces the least. In general, image artifacts are most severe adjacent to the hardware. CT image artifacts are related to incomplete X-ray projection data resulting in streaks. These can be mitigated by increasing scan technique and using a smoother reconstruction filter. Hardware with a rectangular cross-sectional shape such as a fixation plate will cause more artifacts than a radially symmetrical device such as an intramedullary nail. Image artifacts at MR are caused by the hardware magnetic susceptibility and the induction of eddy currents within the metal. A turbo spin-echo sequence yields the best results. The use of larger image matrices, thinner slices, and a wide receiver bandwidth are recommended parameter adjustments when imaging patients with hardware. This article discusses how hardware-related artifacts can be minimized by altering scan technique and image reconstruction.


Subject(s)
Artifacts , Image Interpretation, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Musculoskeletal Diseases/surgery , Postoperative Complications/diagnosis , Prostheses and Implants , Tomography, X-Ray Computed/methods , Humans , Metals , Postoperative Period
8.
Sports Med Arthrosc Rev ; 17(1): 13-20, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19204547

ABSTRACT

Computed tomography (CT) is a widely used imaging technique. With the introduction of multidetector row technology, CT has been further refined. Although the focus of this transformation has been body and cardiac imaging, orthopedic imaging has benefited greatly. Specifically, the improvements in CT have made it possible to obtain submillimeter-thick slices that enable the creation of high-resolution multiplanar reformations from a single scan. These images usually are indistinguishable from direct plane acquisitions and provide unparalleled detail. Additionally, the factors responsible for causing CT image artifacts when hardware is present are much better understood and the improvements in CT technique and technology can be exploited to provide better images of patients with orthopedic hardware. The detailed multiplanar visualization of joints facilitates CT arthrography that has undergone a renaissance. CT arthrography is useful in the very large athlete or patient, the claustrophobic, and for those patients who fail a conventional magnetic resonance examination or magnetic resonance arthrogram.


Subject(s)
Arthrography/methods , Athletic Injuries/diagnosis , Musculoskeletal Diseases/diagnosis , Sports Medicine/methods , Tomography, X-Ray Computed/methods , Humans , Magnetic Resonance Imaging , Musculoskeletal Diseases/pathology , Sports Medicine/instrumentation , Tomography, X-Ray Computed/trends
9.
Radiographics ; 28(3): 771-86, 2008.
Article in English | MEDLINE | ID: mdl-18480483

ABSTRACT

Total hip replacement (THR) requires revision in only a minority of cases (approximately 17% of prosthetic hips fail), but when THR failures occur there may be significant acetabular bone deficiency. There is a variety of surgical hardware and strategies available to address this problem. The causes of primary THR revision include aseptic loosening or particle disease, infection, recurrent dislocation, implant failure, periprosthetic fracture, and leg length discrepancy. Almost all patients who need THR revision undergo a standard radiographic evaluation of the pelvis and hip. In general, CT is an excellent tool for evaluating loosening of the prosthesis caused by either mechanical reasons or infection, and MR imaging is best suited for evaluating the soft tissues surrounding the prosthesis. Nuclear medicine studies are performed when results of CT and MR imaging are inconclusive. When patients are evaluated for revision THR, radiologists must check for acetabular cup loosening, the amount and type of bone stock loss, the amount of component migration, and the presence or absence of liner wear. Before revision hardware is placed, bone stock loss must be repaired, either by using bone grafting or by placing accessory acetabular hardware such as cups, rings, or cages. The long-term success of revision acetabular surgery varies; there is acetabular cup presence at 5 years after surgery in 60%-94% of cases. Complications include postoperative infections, repeat liner wear, bone graft failure, periprosthetic or prosthetic fractures, dislocation, vascular injury, and nerve injury.


Subject(s)
Acetabulum/surgery , Arthroplasty, Replacement, Hip/instrumentation , Arthroplasty, Replacement, Hip/methods , Magnetic Resonance Imaging/methods , Osteoporosis/diagnosis , Osteoporosis/surgery , Tomography, X-Ray Computed/methods , Acetabulum/diagnostic imaging , Acetabulum/pathology , Adult , Aged, 80 and over , Female , Humans , Male , Middle Aged
10.
Pediatr Radiol ; 37(5): 475-82, 2007 May.
Article in English | MEDLINE | ID: mdl-17415601

ABSTRACT

BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in children, with frequent involvement of the metacarpophalangeal joints (MCPJ). OBJECTIVE: To compare US findings with those of radiography and clinical examination. MATERIALS AND METHODS: All MCPJs in 20 children with JIA (17 females, median age 9.7 years, range 3.6 to 16.8 years) were evaluated clinically and imaged with gray-scale and color Doppler US, and 90 MCPJs were also imaged radiographically. Each MCPJ was graded on physical examination from 0 (normal) to 4 (severe) by the patient's rheumatologist. RESULTS: US demonstrated abnormalities in 64 of 200 MCPJs (32.0%), including pannus vascularity and/or tenosynovitis in 55 joints (27.5%) (pannus vascularity in 43, tenosynovitis in 40) and bone destruction in 25 joints (12.5%). Overall, US abnormalities and physical examination scores were significantly associated (P < 0.001). However, interobserver agreement between US and clinical evaluation was poor (kappa 0.1) and between US and radiography was only fair (kappa 0.4). CONCLUSION: US of the MCPJ in children with JIA can demonstrate cartilage thinning, bone erosions, and pannus vascularity. Abnormal US findings are significantly correlated with severity of disease as evaluated clinically.


Subject(s)
Arthritis, Juvenile/diagnosis , Metacarpophalangeal Joint/diagnostic imaging , Adolescent , Child , Child, Preschool , Female , Humans , Male , Observer Variation , Physical Examination/statistics & numerical data , Prospective Studies , Radiography , Severity of Illness Index , Tenosynovitis/diagnosis , Ultrasonography, Doppler, Color/methods
11.
J Pediatr Orthop ; 27(2): 158-64, 2007 Mar.
Article in English | MEDLINE | ID: mdl-17314640

ABSTRACT

We retrospectively identified all children with acute hip pain who underwent pelvic magnetic resonance (MR). Children with septic hip or history of trauma were excluded; the remaining children with signs of infection (fever, >38 degrees C; leukocytosis, >12 x 10(9)/L; or elevated erythrocyte sedimentation rate [ESR], >30 mm/h) comprised the study group. Thirty-three children (9 girls; age, 0.8-15.8 years) were identified. On MR examination, 18 (55%) of 33 children had hip joint effusion, whereas 19 (58%) of 33 children had other abnormalities, including pyomyositis (n=15), osteomyelitis (n=12), and sacroiliitis (n=3). Staphylococcus aureus was cultured from 13 (68%) of these 19 children. Compared with MR, sensitivity for bone and soft tissue abnormalities was 30% for pelvic radiography (n=26) and 71% for bone scintigraphy (n=8). Elevated ESR (>30 mm/h) was the clinical finding that best predicted pelvic osteomyelitis or pyomyositis. Pelvic MR should be performed to rule out pelvic osteomyelitis or pyomyositis in children with acute hip pain, ESR of more than 30 mm/h, and no evidence of septic hip.


Subject(s)
Arthralgia/etiology , Hip Joint , Infections/complications , Infections/diagnosis , Magnetic Resonance Imaging , Osteomyelitis/complications , Osteomyelitis/diagnosis , Pyomyositis/complications , Pyomyositis/diagnosis , Acute Disease , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Osteomyelitis/microbiology , Pelvis , Pyomyositis/microbiology , Retrospective Studies
12.
Ann Rheum Dis ; 66(3): 394-9, 2007 Mar.
Article in English | MEDLINE | ID: mdl-16926185

ABSTRACT

OBJECTIVE: To evaluate the risk factors for early radiographic changes of knee osteoarthritis. SUBJECTS: (n = 114) with unilateral or bilateral grade 0-1 knee osteoarthritis underwent x ray examination of the knees (semiflexed anteroposterior view) and assessment with the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index at baseline and 30 months later. Severity of joint space narrowing (JSN) and osteophytosis were graded in randomly ordered serial radiographs by two readers, blinded to the sequence of the films, using standard pictorial atlases. RESULTS: The odds of an initial appearance of radiographic features of knee osteoarthritis at month 30 were more than threefold greater in African Americans than in whites (osteophytosis: odds ratio (OR) 3.30, 95% confidence interval (CI) 1.04 to 10.54; JSN: OR 3.49, 95% CI 1.16 to 10.68). In addition, the appearance of osteophytosis was positively related to baseline stiffness (OR 1.91/2.1 points on the 2-10 WOMAC scale, 95% CI 1.29 to 2.82). CONCLUSIONS: The distinction between incident and established, but early, radiographic knee osteoarthritis is difficult because of the limits to which all possible evidence of the disease can be ruled out in a conventional baseline knee radiograph. Nonetheless, our finding that African Americans were at greater risk of early osteophytosis and JSN than other subjects differs from the results of our previous analysis of risk factors for progressive knee osteoarthritis in the same subjects. The development of osteophytes also was associated with joint stiffness. Future investigations should focus on the systemic and local influences that these ostensible risk factors represent.


Subject(s)
Osteoarthritis, Knee/diagnostic imaging , Black or African American , Aged , Disease Progression , Female , Follow-Up Studies , Humans , Male , Middle Aged , Osteoarthritis, Knee/ethnology , Osteoarthritis, Knee/pathology , Radiography , Risk Factors , Severity of Illness Index
13.
Semin Musculoskelet Radiol ; 11(3): 261-72, 2007 Sep.
Article in English | MEDLINE | ID: mdl-18260036

ABSTRACT

Postoperative patients may develop complications requiring imaging. Although any imaging technique can be used to investigate these patients, the presence of metal hardware in the region of interest may distort the image and interfere with diagnosis. It is important to understand why this distortion occurs and how to compensate for it. Because some of the most common cross-sectional imaging methods used to image this patient population are computed tomography (CT) and magnetic resonance imaging (MRI), this article focuses on these imaging methods. Metal-related artifacts on CT depend on the hardware alloy, the geometry of the hardware, and the location of the hardware relative to the region of interest. The artifacts may be reduced or eliminated by altering the scan technique, changing the patient position, selecting a smoother CT reconstruction algorithm, and by creating thicker slice multiplanar reformations. Like CT, metal artifacts at MR imaging depend on the type of hardware alloy. Hardware-related artifacts at MR imaging can be reduced by using appropriate pulse sequences, such as fast or turbo spin echo and inversion recovery. Additionally, important pulse sequence modifications that are addressed here include manipulation of the receiver bandwidth and orientation of the frequency encode axis.


Subject(s)
Magnetic Resonance Imaging , Musculoskeletal Diseases/surgery , Postoperative Complications/diagnosis , Prostheses and Implants , Tomography, X-Ray Computed , Artifacts , Humans , Metals , Postoperative Period
14.
Radiographics ; 26 Suppl 1: S97-110, 2006 Oct.
Article in English | MEDLINE | ID: mdl-17050522

ABSTRACT

Evaluating the spine in patients with metal orthopedic hardware is challenging. Although the effectiveness of conventional computed tomography (CT) can be limited by severe beam-hardening artifacts, the evolution of multichannel CT in recent years has made available new techniques that can help minimize these artifacts. Multichannel CT allows faster scanning times, resulting in reduced motion artifacts; thinner sections, with which it is possible to create a scanned volume of isotropic voxels with equivalent image resolution in all planes; and the generation of a higher x-ray tube current, which may result in better penetration of metal hardware and reduction of artifacts. Although 140 kVp and high milliamperage-second exposure are recommended for imaging patients with hardware, caution should always be exercised, particularly in children, young adults, and patients undergoing multiple examinations. The acquisition of multiplanar reformatted images in the axial, sagittal, coronal, and oblique planes and of three-dimensional volume-rendered images optimizes image interpretation. Wide window settings are best for reviewing images when hardware is present. The integrity of hardware is best assessed with multiplanar average intensity projection. Soft-tissue structures are best visualized by interactively varying the window width and level settings. Implementation of these techniques can yield diagnostic-quality images and aid in patient treatment.


Subject(s)
Artifacts , Equipment Failure Analysis/methods , Radiographic Image Enhancement/methods , Spinal Fusion/instrumentation , Spine/diagnostic imaging , Spine/surgery , Tomography, Spiral Computed/methods , Equipment Failure Analysis/instrumentation , Humans , Metals , Postoperative Care/methods , Prognosis , Tomography, Spiral Computed/instrumentation
16.
Rheumatology (Oxford) ; 45(11): 1389-94, 2006 Nov.
Article in English | MEDLINE | ID: mdl-16606655

ABSTRACT

OBJECTIVE: To determine the extent to which treatment of patients with symptomatic knee osteoarthritis (OA) with non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (ACET) reduces total effusion volume and synovial tissue volume, as quantified by magnetic resonance imaging (MRI). METHODS: Sequential pilot studies used subjects whose knee OA was treated with NSAIDs (n=10) or with ACET or=15 of 25 on the Western Ontario and McMaster Universities' pain scale underwent l.5T MRI. Effusion was quantified in axial short tau inversion recovery images; to measure synovial tissue volume, fat-suppressed T1-weighted axial images were obtained 3 min after i.v. injection of gadolinium contrast. After the initial MRI examination, patients resumed their customary pain medications until the severity of knee pain returned to baseline, when pain was again measured and the MRI was repeated. RESULTS: Pain severity after washout was similar in subjects taking ACET and NSAIDs. Reinstitution of ACET resulted in a 50% decrease in the mean of pain scores (P=1.7 x 10(-12)) that was comparable with that seen after the reinstitution of NSAID (49%, P=6.0 x 10(-7)). The mean total effusion volume measured during the flare of knee pain induced by the withdrawal of the two drugs was comparable (ACET 16.9 ml, NSAID 16.2 ml; P=0.884). Significant decreases in mean total effusion volume were observed after reinstitution of both ACET (-4.5 ml, P=0.009) and NSAID (-3.3 ml, P=0.013); the difference between drugs was not significant. Analyses of synovial volume yielded similar results. CONCLUSION: While uncontrolled and derived from small samples, these data suggest that ACET may have a significant anti-inflammatory effect in patients with knee OA, comparable with that achieved with NSAIDs, possibly through an effect on neurogenic inflammation. Joint pain is the clinical feature of OA that most often leads the affected individual to seek medical attention. Because many patients with OA improve symptomatically with the use of NSAIDs, it has been widely assumed that the pain of OA is due to synovial inflammation. However, the origins of OA pain are numerous and may vary from patient to patient and, within the same subject, from visit to visit. Although the articular cartilage is usually the site of the most obvious pathological changes in this disease, it is aneural and, therefore, is not the source of joint pain. However, in addition to the synovium, the subchondral bone, joint capsule, osteophytes, menisci, ligaments, periarticular tendons, entheses and bursae all contain nociceptive nerve endings, stimulation of which by chemical or physical mediators may be a basis for OA pain.


Subject(s)
Acetaminophen/therapeutic use , Analgesics, Non-Narcotic/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Osteoarthritis, Knee/drug therapy , Synovitis/drug therapy , Aged , Female , Humans , Image Processing, Computer-Assisted/methods , Magnetic Resonance Imaging , Male , Middle Aged , Osteoarthritis, Knee/complications , Osteoarthritis, Knee/pathology , Pain/drug therapy , Pain/etiology , Pain Measurement/methods , Pilot Projects , Synovitis/etiology , Synovitis/pathology , Treatment Outcome
17.
Semin Musculoskelet Radiol ; 10(1): 86-97, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16514583

ABSTRACT

The introduction of multichannel CT scanners provides both radiologists and surgeons with a new tool to image patients with orthopedic hardware. The key parameters that have made it possible to image the implants and the surrounding bone with multichannel CT are the higher available technical factors (kVp and mAs) coupled with the ability to acquire thin slices over a large scan region. These properties make it possible to produce high-quality multiplanar reformations that facilitate visualization of the orthopedic device and the surrounding bone. An important consideration for multichannel CT imaging of hardware is the reduction of cone beam artifacts caused by the geometry of multichannel CT scanners. This artifact is reduced by using a narrower x-ray beam collimation and a low pitch setting. This article discusses CT scan parameters and image postprocessing used at our institution and illustrates common clinical problems encountered when imaging implanted orthopedic devices. These include fracture healing, loosening of joint prostheses, evaluation of particle disease, and the use of CT for preoperative planning in revision arthroplasty.


Subject(s)
Prostheses and Implants , Tomography, X-Ray Computed/methods , Equipment Failure , Hip Joint/diagnostic imaging , Hip Joint/surgery , Humans , Knee Joint/diagnostic imaging , Knee Joint/surgery , Orthopedic Equipment/adverse effects , Prostheses and Implants/adverse effects , Shoulder Joint/diagnostic imaging , Shoulder Joint/surgery
18.
Pediatr Radiol ; 36(4): 338-43, 2006 Apr.
Article in English | MEDLINE | ID: mdl-16474970

ABSTRACT

BACKGROUND: Acute pelvic pyomyositis is uncommon in non-tropical areas. OBJECTIVE: To summarize the clinical and MR findings in children with acute pelvic pyomyositis. MATERIALS AND METHODS: We retrospectively identified 20 children (mean age 9.4 years) who were evaluated by MR and diagnosed with acute pelvis pyomyositis during the time period between January 2002 and June 2005. We reviewed clinical, laboratory, and imaging findings. RESULTS: Fifteen of the 20 children had secondary pyomyositis associated with osteomyelitis (n=13), septic hip (n=4) or sacroiliitis (n=4); all were previously healthy except for one child with leukemia. Seven of the children with secondary pyomyositis underwent bone scintigraphy; three (43%) did not show pelvic abnormalities. Staphylococcus aureus was cultured in 13 of the 15 (87%) children. Five of the 20 children had primary pyomyositis. Three had underlying disease and two others were engaged in vigorous physical activity. Bone scintigraphies (n=2) were negative. Cultures were positive for S. aureus in three of the five (60%) children. CONCLUSION: Septic hip should be the first diagnostic consideration in children with fever and acute hip pain. Pyomyositis should be considered if arthrocentesis is negative or there is clinical suspicion of infection outside the hip joint. MR is the preferred imaging modality for evaluating foci of pyomyositis, muscle abscesses, and additional foci of infection within the pelvis.


Subject(s)
Hip Joint/pathology , Magnetic Resonance Imaging/methods , Myositis/diagnosis , Pelvic Infection/diagnosis , Staphylococcal Infections/diagnosis , Acute Disease , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Prognosis , Reproducibility of Results , Retrospective Studies , Sensitivity and Specificity
19.
AJR Am J Roentgenol ; 185(2): 371-8, 2005 Aug.
Article in English | MEDLINE | ID: mdl-16037507

ABSTRACT

OBJECTIVE: This study was performed to determine whether a modified version of the classic STIR sequence provides similar information about the integrity of the rotator cuff tendon as the commonly used fat-suppressed T2-weighted fast spin-echo sequence. SUBJECTS AND METHODS: Sixty-one consecutive MRI examinations of the shoulder in 57 patients were performed using a coronal oblique T1-weighted spin-echo sequence, a modified version of the STIR sequence, and a fat-suppressed T2-weighted fast spin-echo sequence. Three reviewers independently assessed the rotator cuff tendon using the coronal oblique modified inversion recovery sequence and T1-weighted spin-echo sequence. After a minimum of 4 weeks, reviewers assessed the rotator cuff tendon using the fat-suppressed T2-weighted fast spin-echo sequence and T1-weighted spin-echo sequence. The kappa statistic was used to measure the degree of concordance between interpretations when each sequence was used independently. The conditional probability that a full- and a partial-thickness tear would be diagnosed on both sequences was calculated. Image quality was assessed in a side-by-side comparison. RESULTS: The overall weighted kappa score was 0.82, which indicates excellent concordance between the two sequences. If a full-thickness tear of the rotator cuff tendon was found on the fat-suppressed T2-weighted fast spin-echo sequence, there was a 94.1% probability that the same conclusion would be reached using the modified inversion recovery sequence. If a partial-thickness tear was found on the fat-suppressed T2-weighted fast spin-echo sequence, there was an 80.3% probability that the same conclusion would be reached with the modified inversion recovery sequence. Fat suppression in the modified inversion recovery sequence was superior to that in the T2-weighted fast spin-echo sequence in 26-39% of the examinations. CONCLUSION: The modified inversion recovery sequence and fat-suppressed T2-weighted fast spin-echo sequence provide similar information about the integrity of the rotator cuff tendon.


Subject(s)
Magnetic Resonance Imaging/methods , Rotator Cuff/pathology , Adult , Aged , Female , Humans , Male , Middle Aged , Observer Variation , Rotator Cuff Injuries , Shoulder Pain/etiology
20.
Arthritis Rheum ; 52(7): 2015-25, 2005 Jul.
Article in English | MEDLINE | ID: mdl-15986343

ABSTRACT

OBJECTIVE: To confirm preclinical data suggesting that doxycycline can slow the progression of osteoarthritis (OA). The primary outcome measure was joint space narrowing (JSN) in the medial tibiofemoral compartment. METHODS: In this placebo-controlled trial, obese women (n = 431) ages 45-64 years with unilateral radiographic knee OA were randomly assigned to receive 30 months of treatment with 100 mg doxycycline or placebo twice a day. Tibiofemoral JSN was measured manually in fluoroscopically standardized radiographic examinations performed at baseline, 16 months, and 30 months. Severity of joint pain was recorded at 6-month intervals. RESULTS: Seventy-one percent of all randomized subjects completed the trial. Radiographs were obtained from 85% of all randomized subjects at 30 months. Adherence to the dosing regimen was 91.8% among subjects who completed the study per protocol. After 16 months of treatment, the mean +/- SD loss of joint space width in the index knee in the doxycycline group was 40% less than that in the placebo group (0.15 +/- 0.42 mm versus 0.24 +/- 0.54 mm); after 30 months, it was 33% less (0.30 +/- 0.60 mm versus 0.45 +/- 0.70 mm). Doxycycline did not reduce the mean severity of joint pain, although pain scores in both treatment groups were low at baseline and remained low throughout the trial, suggesting the presence of a floor effect. However, the frequency of followup visits at which the subject reported a > or = 20% increase in pain in the index knee, relative to the previous visit, was reduced among those receiving doxycycline. In contrast, doxycycline did not have an effect on either JSN or pain in the contralateral knee. In both treatment groups, subjects who reported a > or = 20% increase in knee pain at the majority of their followup visits had more rapid JSN than those whose pain did not increase. CONCLUSION: Doxycycline slowed the rate of JSN in knees with established OA. Its lack of effect on JSN in the contralateral knee suggests that pathogenetic mechanisms in that joint were different from those in the index knee.


Subject(s)
Anti-Infective Agents/therapeutic use , Doxycycline/therapeutic use , Osteoarthritis, Knee/drug therapy , Double-Blind Method , Female , Femur/diagnostic imaging , Health Status , Humans , Knee Joint/diagnostic imaging , Knee Joint/drug effects , Knee Joint/pathology , Middle Aged , Obesity , Osteoarthritis, Knee/diagnostic imaging , Osteoarthritis, Knee/physiopathology , Pain/physiopathology , Pain/prevention & control , Radiography , Severity of Illness Index , Tibia/diagnostic imaging , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL
...