ABSTRACT
BACKGROUND: Many ca. survivors exhibit signs of IR, an important risk factor for the development of CAD. CAC scans offer a risk assessment of CV disease before cardiac damage has occurred. We investigated how IR affects CAC scores in cancer survivors. OBJECTIVES: The aim of this study was to show that CAC scores differ significantly between insulin-sensitive- and -resistant cancer survivors. METHODS: We enrolled 90 cancer survivors of a large community hospital from March 2021 to January 2022 into this pilot study. Patients were subdivided into three groups: insulin-sensitive (IS), insulin-resistant/prediabetic and insulin-resistant/diabetic. All patients received a CAC scan. RESULTS: 70% of asymptomatic survivors overall and 81% of asymptomatic IR patients show CAD on CAC scans. 17 CAC scans in the IS group, 6 CAC scans in the IR/prediabetic group and 5 CAC scans in the IR/diabetic group showed an Agatston score of 0. The p-value between the three groups was statistically significant (p = 0.005) whereas the IR/prediabetic- and the IR/diabetic group did not differ statistically from each other. The mean MESA 10-year CHD risk with CAC was 7.8. There was a highly significant difference between the 3 groups (p < 0.001). The two IR groups did not differ statistically (p = 0.076). CONCLUSIONS: Survivors with IR including prediabetes have less frequent zero CAC scores than insulin-sensitive survivors. Our study also showed that IR including prediabetes significantly increases the MESA 10-yr. CHD Risk with CAC in cancer survivors. This trial highlights the importance of screening survivors for IR and draws attention to the association of IR to CAC not only in diabetes but also in prediabetes. The high fraction of asymptomatic survivors with CAD is concerning and calls for further investigation. CAC scans are an inexpensive and efficient way of screening asymptomatic cancer survivors for CAD.
ABSTRACT
Spintronics materials have recently been considered for radio-frequency devices such as oscillators by exploiting the transfer of spin angular momentum between a spin-polarized electrical current and the magnetic nanostructure it passes through. While previous spin-transfer oscillators (STOs) were based on in-plane magnetized structures, here we present the realization of an STO that contains a perpendicular spin current polarizer combined with an in-plane magnetized free layer. This device is characterized by high-frequency oscillations of the free-layer magnetization, consistent with out-of-plane steady-state precessions induced at the threshold current by a spin-transfer torque from perpendicularly polarized electrons. The results are summarized in static and dynamic current-field state diagrams and will be of importance for the design of STOs with enhanced output signals.
ABSTRACT
Nucleation and annihilation of vortex states have been studied in two-dimensional arrays of densely packed cobalt dots. A clear signature of dipolar interactions both between single-domain state dots and vortex state dots has been observed from the dependence of vortex nucleation and annihilation fields on interdot separation. A direct consequence of these interactions is the formation of vortex chains as well as dipole chains aligned along the direction of the external field. In addition, short range correlation of chiralities within vortex chains has been observed using magnetic force microscopy imaging and has been attributed to cross-talking between adjacent elements.
ABSTRACT
Measurements are reported on the magnetization reversal in submicron magnetic rings fabricated by high-resolution electron beam lithography and lift-off from cobalt thin films. For all dimensions investigated, with diameters of 300-800 nm and a thickness of 10-50 nm, the flux closure state is the stable magnetization configuration. However, with increasing diameter and decreasing film thickness a metastable near single domain state can be obtained during the reversal process in an in-plane applied field.
ABSTRACT
A patient with a hereditary neuropathy presented with a conus and cauda syndrome. CSF study showed a high protein content. Neuroradiological investigation results were consistent with a compression TH11-L4. The patient underwent TH11-L4 laminectomy.
