[The solubility of welding dusts and their cytotoxicity]. / Rastvorimost' svarochnykh pylei i ikh tsitotoksichnost'.

It was established as a result of cytotoxicity studies of 15 welding dusts of different compositions in experiments on embryonal fibroblast cell cultures that the biologic activity of these substances depends on the solubility in growth media of their major components: alkaline and alkaline earth metals, iron, cremnium and, to a vast degree, that of the manganese. Conclusion has been made that a comparative assessment of welding dusts' biological activity on cell cultures should involve the kinetic parameters of their solubility in growth and supportive media, and the duration of the substances' affecting the cell cultures should be long enough to reveal the combined action of its major ingredients.

[Complex formation of lithium hydroxybutyrate with ions of Na+, K+, Ba2+, Mg2+, and Ca2+]. / Kompleksoobrazovanie litiia oksibutirata s ionami Na+, K+, Ba2+, Mg2+, and Ca2+.

The interaction of lithium hydrobutyrate (LiR) with ions of Na+, K+, Ba2+, Mg2+ and Ca2+ was studied. The coordination is implemented by atoms of oxygen of the carboxyl group. R forms the most stable complexes with ions of Mg2+ and Ca2+. Complexes of CaR+ and CaR2 types are formed with ions of Mg2+ and Ca2+. For LiR complex the logarithm of stability constant (lg K) is 0.7 +/- 0.3, for CaR+ - 2.0 +/- 0.2 and for CaR2 - 0.2 +/- 0.3. The interaction of lithium hydroxybutyrate with ions of Ca2+ and Mg2+ may be of great importance in the mechanism of its cardiotropic effect.

[Interaction of beta-adrenergic agents with the plasma membranes of the myocardium]. / Vzaimodeistvie beta-adrenergicheskikh sredstv s plazmaticheskimi membranami miokarda.

The initial stage of interaction of beta-adrenomimetics and beta-adrenoblockers with specific membrane binding sites is characterized by different patterns of thermodynamic parameters. Administration of isadrin results in a decrease of entropy and enthalpy, which reflects the primary binding reaction and agonist-specific receptor isomerization to the conformational form activating adenylate cyclase. Anaprilin and alpheprol do not change the receptor conformation and participate only in the primary binding reaction which is marked by a decrease in enthalpy and a rise of entropy in the course of interaction of beta-adrenoblockers with specific membrane binding sites. The different patterns of thermodynamic parameters under the effect of beta-adrenomimetics and beta-adrenoblockers on plasma membranes are explained by the different influence of these substances on the mobility of membrane lipids, i.e. on the viscosity of plasma membranes.

[Pharmacological aspects of digoxin complex formation with calcium and magnesium cations]. / Farmakologicheskie aspekty kompleksoobrazovaniia digoksina s kationami kal'tsiia i magniia.

NMR spectroscopy was used to establish the formation of digoxin and digitoxin complexes with calcium ions. Microcolorimetric titration demonstrated the formation of two types of digoxin complexes with magnesium at a ratio of 1:1 and 1:2. It was noticed in rat experiments that digoxin (2.5 mg/kg) raises the magnesium level in liver tissue, whereas in a toxic dose of 12.5 mg/kg it increases the calcium content in the heart muscle.

[K-strophanthin-beta complexing with calcium, magnesium and dysprosium ions]. / Kompleksoobrazovanie k-strofantina-beta s ionami kal'tsiia, magniia i disproziia.

Nuclear magnetic resonance, microcalorimetry and the use of the ion-selecting electrode evidenced that k-strophanthine-beta forms complexes with the calcium, magnesium and disprosium ions. Changes in the position of the k-strophanthine-beta carbohydrate parts and aglycones signals bear witness to their participation in the complexing.