[High pressure liquid chromatographic methods for compendium of purity tests]. / Gyógyszerkönyvi tisztaságvizsgálati feladatok megoldása nagyhatékonyságú folyadékkromatográfiával.

The paper is addressed to the institute of Pharmaceutical Chemistry, Budapest, on the 50th anniversary of its foundation, paying tribute to Prof. Antal Végh, the first director of the Institute and his first deputy dr. László Auber and all the members of the Staff having merit in developing the research activity at the Department. After surveying the early papers published from the fifties through the seventies, concerning the profile of drug purity control, the factors increasing HPLC selectivity are shortly reviewed. In the concluding part of the paper, some recent results, as HPLC purity control methods suitable for compendial purposes (methylxanthines, opium alkaloids, tropane-alkaloids, enantiomer purity control of different drug compounds on glycoprotein and chirelcel columns) are summarized.

Partitioning behaviour of local anesthetic fomocaine derivatives.

The octanol/water partitioning behaviour of local anesthetic fomocaine derivatives has been investigated. The true partition coefficients obtained from log P(app) values reflect well the high lipophilicity of these aminoalkylaryl-ether type compounds. A consequence of this is that the partitioning of the protonated form is not negligible as was proved by the log P(i) values of the ionized molecule measured at pH 4.0. The effect of ionization on partitioning was studied and characterized by the pQ values. This ionization influence on lipophilicity was found quite constant (pQ approximately 4) among the hydroxypiperidine analogs. A parabolic relationship was obtained between the acute toxicity and the log P values of several of the examined compounds.