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1.
JAMA ; 322(15): 1453-1454, 2019 Oct 15.
Article in English | MEDLINE | ID: mdl-31613349
2.
Congenit Heart Dis ; 13(6): 919-926, 2018 Nov.
Article in English | MEDLINE | ID: mdl-30095223

ABSTRACT

BACKGROUND: Single ventricle heart disease with aortic arch hypoplasia has high morbidity and mortality, with the greatest risk after stage 1 palliation. Residual lesions often require catheter-based or surgical reintervention to minimize risk. We sought to describe the types, frequency, and risk factors for re-intervention between stage 1 and stage 2 palliation, utilizing the National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) registry. METHODS: The NPC-QIC registry, consisting of patients discharged after stage 1 palliation, was queried. Hybrid stage 1 palliation patients were excluded from this study. The primary risk factor was shunt type and the primary outcome was re-intervention. RESULTS: Of 1156 patients, (50%) had re-intervention. There was no difference in total rate of re-intervention by shunt type (BT shunt 52% vs. RVPA shunt 48%; P = .17). Patients with a BT shunt had increased re-intervention during stage 1 hospitalization (P =.002). During the interstage period, following discharge from stage 1 palliation, patients with a BT shunt had increased aortic arch re-intervention (P < .005), while patients with an RVPA shunt had increased re-intervention on the shunt and the pulmonary arteries (P = .02). Postoperative mechanical ventilation >14 d (P < .01) was the only risk factor associated with re-intervention by multivariable analysis, regardless of shunt type. CONCLUSIONS: Re-intervention between stage I and stage 2 palliation is common. There is no difference in cumulative frequency of re-intervention between shunt types, though types and timing of re-intervention varied between shunt types. Longitudinal assessment of the NPC-QIC database is important to identify long term outcomes of patients requiring re-intervention.


Subject(s)
Heart Ventricles/abnormalities , Hypoplastic Left Heart Syndrome/surgery , Norwood Procedures/methods , Palliative Care/methods , Quality Improvement , Registries , Female , Follow-Up Studies , Heart Ventricles/surgery , Humans , Infant, Newborn , Male , Reoperation , Retrospective Studies , Risk Factors , Treatment Outcome
3.
J Pediatr Surg ; 53(6): 1118-1122, 2018 Jun.
Article in English | MEDLINE | ID: mdl-29605269

ABSTRACT

INTRODUCTION: Isomerism, or heterotaxy syndrome, affects many organ systems anatomically and functionally. Intestinal malrotation is common in patients with isomerism. Despite a low reported risk of volvulus, some physicians perform routine screening and prophylactic Ladd procedures on asymptomatic patients with isomerism who are found to have intestinal malrotation. The primary aim of this study was to determine if isomerism is an independent risk factor for volvulus. METHODS: Kid's Inpatient Database data from 1997 to 2012 was utilized for this study. Characteristics of admissions with and without isomerism were compared with a particular focus on intestinal malrotation, volvulus, and Ladd procedure. A logistic regression was conducted to determine independent risk factors for volvulus with respect to isomerism. RESULTS: 15,962,403 inpatient admissions were included in the analysis, of which 7970 (0.05%) patients had isomerism, and 6 patients (0.1%) developed volvulus. Isomerism was associated with a 52-fold increase in the odds of intestinal malrotation by univariate analysis. Of 251 with isomerism and intestinal malrotation, only 2.4% experienced volvulus. Logistic regression demonstrated that isomerism was not an independent risk factor for volvulus. CONCLUSION: Isomerism is associated with an increased risk of intestinal malrotation but is not an independent risk factor for volvulus. TYPE OF STUDY: Prognosis study. LEVEL OF EVIDENCE: Level III.


Subject(s)
Heterotaxy Syndrome/complications , Intestinal Volvulus/etiology , Adolescent , Child , Child, Preschool , Cross-Sectional Studies , Female , Heterotaxy Syndrome/diagnosis , Humans , Infant , Infant, Newborn , Logistic Models , Male , Prognosis , Risk Factors
4.
Congenit Heart Dis ; 12(4): 435-440, 2017 Jul.
Article in English | MEDLINE | ID: mdl-28464509

ABSTRACT

OBJECTIVE: Abnormal lung function characterized by a reduced forced vital capacity (FVC) is common in adults with repaired tetralogy of Fallot (TOF) and is associated with previous thoracotomies and sternotomies. The impact of abnormal lung function on clinical outcomes in adult patients with repaired TOF is unclear. The aim of this study was to determine the impact of abnormal lung function on the outcome of hospitalization and death in adults with repaired TOF when analyzed with other traditional cardiac risk factors. DESIGN: Retrospective study of adults with repaired TOF, who underwent spirometry between 2000 and 2014. FVC < 60% of predicted was categorized as moderate-to-severely reduced lung function. Primary outcome measure was the combined clinical endpoint of death, cardiac transplantation, or nonelective hospitalization for primary cardiac or respiratory indication. RESULTS: A total of 122 patients were included. Average age at spirometry testing was 31 ± 10.1 years. FVC was < 60% predicted in 23 (19%) patients. During a mean follow-up period of 3.97 ± 2.65 years, 23 (19%) patients reached the combined clinical outcome of nonelective hospitalization and/or death. FVC < 60% predicted was independently associated with the risk for the combined clinical outcome (RR 6.68 (95% CI 2.49-17.94), P < .001). CONCLUSIONS: Abnormal pulmonary function characterized by reduced FVC is common in adults with repaired TOF. Patients with FVC < 60% predicted had a 6 times higher rate of hospitalization and/or death compared to those with FVC ≥ 60%.


Subject(s)
Cardiac Surgical Procedures , Lung/physiopathology , Risk Assessment/methods , Tetralogy of Fallot/epidemiology , Vital Capacity/physiology , Adult , Exercise Test , Female , Follow-Up Studies , Forced Expiratory Volume , Humans , Male , Morbidity/trends , Postoperative Period , Retrospective Studies , Spirometry , Survival Rate/trends , Tetralogy of Fallot/physiopathology , Tetralogy of Fallot/surgery , Wisconsin/epidemiology
5.
Pediatr Cardiol ; 38(5): 893-901, 2017 Jun.
Article in English | MEDLINE | ID: mdl-28190140

ABSTRACT

It is unclear if neonatal tetralogy of Fallot repair offers better outcomes compared to repair later in infancy. We therefore conducted a meta-analysis comparing outcomes of neonatal and non-neonatal repair. Manuscripts were identified and reviewed for quality and bias with favorably scored manuscripts being included in the final meta-analysis. Several perioperative and postoperative variables were compared. A total of 8 studies with 3858 patients were included in the analysis. Of these patients, 19% underwent neonatal repair. Neonatal repair was associated with increased mortality, longer intensive care unit stays, and longer total hospital length of stay.


Subject(s)
Tetralogy of Fallot/surgery , Age Factors , Cardiac Surgical Procedures/adverse effects , Cardiac Surgical Procedures/mortality , Humans , Infant , Infant, Newborn , Time Factors
6.
Pacing Clin Electrophysiol ; 40(4): 353-361, 2017 Apr.
Article in English | MEDLINE | ID: mdl-27987225

ABSTRACT

INTRODUCTION: An increasing number of patients with congenital heart disease are now surviving into adulthood. This has also led to the emergence of complications from the underlying congenital heart disease, related surgical interventions, and associated combordities. While the prevalence of particular arrhythmias with specific congenital heart disease has been previously described, a detailed analysis of all lesions and a large number of comorbidities has not been previously published. METHODS: Admissions with congenital heart disease were identified in the National Inpatient Sample. Associated comorbidities were also identified for these patients. Univariate analysis was done to compare those risk factors associated with specific arrhythmias in the setting of congenital heart disease. Next, regression analysis was done to identify what patient characteristics and comorbidities were associated with increased risk of specific arrhythmias. RESULTS: A total of 52,725,227 admissions were included in the analysis. Of these, 109,168 (0.21%) had congenital heart disease. Of those with congenital heart disease, 27,088 (25%) had an arrhythmia at some point. The most common arrhythmia in those with congenital heart disease was atrial fibrillation, which was noted in 86% of those with arrhythmia followed by atrial flutter which was noted in 20% of those with congenital heart disease. The largest burden of arrhythmia was found to be in those with tricuspid atresia with a 51% prevalence of arrhythmia in this group followed by Ebstein anomaly which had an arrhythmia prevalence of 39%. Increasing age, male gender, double outlet right ventricle, atrioventricular septal defect, heart failure, obstructive sleep apnea, transposition of the great arteries, congenitally corrected transposition, and tetralogy of Fallot were frequently noted to be independent risk factors of specific arrhythmias. CONCLUSION: Approximately, 25% of adult admissions with congenital heart disease are associated with arrhythmia. The burden of arrhythmia varies by the specific lesion and other risk factors as well. Understanding of these can help in risk stratification and can help devise strategies to lower this risk.


Subject(s)
Arrhythmias, Cardiac/epidemiology , Heart Defects, Congenital/epidemiology , Patient Admission/statistics & numerical data , Age Distribution , Aged , Arrhythmias, Cardiac/diagnosis , Causality , Comorbidity , Female , Heart Defects, Congenital/diagnosis , Humans , Male , Middle Aged , Prevalence , Risk Factors , Sex Distribution , United States/epidemiology
7.
World J Pediatr Congenit Heart Surg ; 7(3): 385-8, 2016 May.
Article in English | MEDLINE | ID: mdl-26701624

ABSTRACT

The surgical palliation of several congenital heart defects requires the use of a conduit, particularly between the right ventricle and the pulmonary artery. Contegra, a valved bovine vein conduit, is a conduit frequently used. Pseudoaneurysms, aneurysms, and dissections have seldom been reported with Contegra conduits but are potential complications associated with these conduits. We report a new case of Contegra dissection.


Subject(s)
Aortic Dissection/diagnostic imaging , Bioprosthesis , Blood Vessel Prosthesis , Heart Defects, Congenital/diagnostic imaging , Heart Failure/diagnostic imaging , Aortic Dissection/surgery , Animals , Cattle , Heart Defects, Congenital/surgery , Heart Failure/surgery , Heart Ventricles/diagnostic imaging , Heart Ventricles/pathology , Heart Ventricles/surgery , Humans , Infant , Male , Pulmonary Artery/diagnostic imaging , Pulmonary Artery/pathology , Pulmonary Artery/surgery , Treatment Outcome
8.
Congenit Heart Dis ; 10(5): E197-202, 2015.
Article in English | MEDLINE | ID: mdl-25916657

ABSTRACT

OBJECTIVE: The impact of obesity on surgical morbidity in adults with congenital heart disease is currently unknown. The aim of our study was to investigate the impact of obesity on postoperative outcomes in adults with congenital heart disease undergoing reoperation for pulmonary valve replacement. METHODS: A retrospective analysis was performed assessing the influence of obesity on surgical outcomes. Obesity was defined as a body mass index ≥30 kg/m2. RESULTS: The mean body mass index of the cohort was 25.9 ± 6.9 kg/m2 . The cohort included 71 patients with 17 patients (24%) being obese. There was no postoperative mortality. Obese patients had a longer hospital length of stay (6.6 vs. 4.7 days; P < .001) and increased incidence of postoperative arrhythmias (29% vs. 5.6%; P = .003) compared with nonobese patients. Multivariable analysis performed using logistic regression with backwards elimination demonstrated obesity was independently associated with hospital length of stay >5 days (odds ratio [OR] = 5.2; 95% confidence interval [CI]: 1.5-18.2, P = .01) and with increased postoperative arrhythmias (OR = 4.2; 95% CI: 1.7-40, P < .01). CONCLUSIONS: Obesity is associated with increased morbidity in adults with congenital heart disease undergoing pulmonary valve replacement, including longer hospitalization and higher risk for postoperative arrhythmias.


Subject(s)
Heart Defects, Congenital/surgery , Heart Valve Prosthesis Implantation , Obesity/complications , Pulmonary Valve/surgery , Adolescent , Adult , Arrhythmias, Cardiac/etiology , Body Mass Index , Female , Heart Defects, Congenital/complications , Heart Defects, Congenital/diagnosis , Heart Defects, Congenital/physiopathology , Heart Valve Prosthesis Implantation/adverse effects , Humans , Length of Stay , Logistic Models , Male , Middle Aged , Multivariate Analysis , Obesity/diagnosis , Odds Ratio , Pulmonary Valve/physiopathology , Reoperation , Retrospective Studies , Risk Assessment , Risk Factors , Time Factors , Treatment Outcome , Wisconsin , Young Adult
9.
Microvasc Res ; 89: 134-45, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23628292

ABSTRACT

OBJECTIVES: We investigated the effect of suppressing plasma angiotensin II (ANG II) levels on arteriolar relaxation in the hamster cheek pouch. METHODS: Arteriolar diameters were measured via television microscopy during short-term (3-6days) high salt (HS; 4% NaCl) diet and angiotensin converting enzyme (ACE) inhibition with captopril (100mg/kg/day). RESULTS: ACE inhibition and/or HS diet eliminated endothelium-dependent arteriolar dilation to acetylcholine, endothelium-independent dilation to the NO donor sodium nitroprusside, the prostacyclin analogs carbacyclin and iloprost, and the KATP channel opener cromakalim; and eliminated arteriolar constriction during KATP channel blockade with glibenclamide. Scavenging of superoxide radicals and low dose ANG II infusion (25ng/kg/min, subcutaneous) reduced oxidant stress and restored arteriolar dilation in arterioles of HS-fed hamsters. Vasoconstriction to topically-applied ANG II was unaffected by HS diet while arteriolar responses to elevation of superfusion solution PO2 were unaffected (5% O2, 10% O2) or reduced (21% O2) by HS diet. CONCLUSIONS: These findings indicate that sustained exposure to low levels of circulating ANG II leads to widespread dysfunction in endothelium-dependent and independent vascular relaxation mechanisms in cheek pouch arterioles by increasing vascular oxidant stress, but does not potentiate O2- or ANG II-induced constriction of arterioles in the distal microcirculation of normotensive hamsters.


Subject(s)
Angiotensin II/metabolism , Endothelium, Vascular/pathology , Oxidants/chemistry , Acetylcholine/chemistry , Animals , Arterioles/drug effects , Arterioles/metabolism , Blood Pressure , Captopril/chemistry , Cheek/blood supply , Cricetinae , Cromakalim/chemistry , Epoprostenol/analogs & derivatives , Epoprostenol/chemistry , Glyburide/chemistry , Iloprost/chemistry , Male , Mesocricetus , Microscopy , Microscopy, Video , Nitroprusside/chemistry , Oxygen/chemistry , Peptidyl-Dipeptidase A/metabolism , Superoxides/chemistry , Vascular Diseases/pathology
10.
Pediatr Cardiol ; 34(1): 165-9, 2013 Jan.
Article in English | MEDLINE | ID: mdl-22673967

ABSTRACT

Long-term survival after tetralogy of Fallot (TOF) repair is excellent. However, little is published regarding late noncardiac complications. This study aimed to determine the prevalence and risk factors for renal dysfunction among adults after TOF repair. For this study, 56 adult patients with complete repair of TOF were identified, and their charts were retrospectively reviewed. An estimated glomerular filtration rate (eGFR) for each patient was calculated using the Modification of Diet in Renal Disease formula (MDRD). Using each patient's eGFR, he or she was classified into stages based on the National Kidney Foundation chronic kidney disease (CKD) staging. Clinical parameters were compared among patients with and those without renal dysfunction to identify risk factors for renal impairment. The median estimated eGFR rate for the cohort was 78 ml/min/1.73 m(2). Based on the National Kidney Foundation CKD staging system, 54 % of the patients had at least stage 2 chronic renal disease. The risk factors identified were hypertension (p < 0.01), type 2 diabetes mellitus (p < 0.05), longer follow-up evaluation (p < 0.005), older age at complete repair (p < 0.05), and use of daily diuretics (p < 0.05). After repair of TOF, renal dysfunction is common at late follow-up evaluation. The study findings show the importance of routine assessment of renal function and the need to limit or avoid future episodes of acute kidney injury in this at-risk population.


Subject(s)
Kidney/physiopathology , Tetralogy of Fallot/surgery , Adolescent , Adult , Aged , Female , Follow-Up Studies , Glomerular Filtration Rate , Humans , Male , Middle Aged , Palliative Care , Prevalence , Renal Insufficiency, Chronic/diagnosis , Renal Insufficiency, Chronic/physiopathology , Retrospective Studies , Risk Assessment , Risk Factors , Young Adult
11.
Congenit Heart Dis ; 7(5): 441-7, 2012.
Article in English | MEDLINE | ID: mdl-22537138

ABSTRACT

BACKGROUND: It is becoming increasingly recognized that manifestations of congenital heart disease (CHD) extend beyond the cardiovascular system. The factors contributing to renal dysfunction in patients with CHD are multifactorial, with acute kidney injury (AKI) at time of cardiac surgery playing a major role. AKI is often diagnosed based on changes in serum creatinine and estimated glomerular filtration rate (eGFR). Such measurements are often late and imprecise. Recent data indicate that urinary biomarkers interleukin-18 (IL-18) and neutrophil gelatinase-associated lipocalin (NGAL) are earlier markers of AKI. We sought to determine the efficacy of urinary IL-18 and NGAL for detecting early AKI in patients undergoing surgical pulmonary valve replacement (PVR). METHODS: Twenty patients presenting for surgical PVR with a history of previous repair of a conotruncal anomaly were enrolled. Preoperative clinical data were measured and urine samples and serum creatinine were collected at 6, 12, 24, and 72 hours post bypass. Urine was evaluated for NGAL and IL-18. AKI was determined using the Risk, Injury, Failure, Loss and End Stage Renal Disease (RIFLE) classification system. RESULTS: Using the RIFLE classification system, seven patients (35%) were found to have AKI defined as a drop in the eGFR or an increase in serum creatinine. All seven patients with AKI had marked increase from preoperative baseline in urine IL-18 (sixfold) and NGAL (26-fold). Using NGAL and IL-18, AKI was detected at 6 hours postoperatively, resulting in AKI being identified 12-36 hours prior to detection by conventional methods. No preoperative predictors for AKI were identified. CONCLUSION: Both NGAL and IL-18 are early predictive biomarkers of AKI, and both increase in tandem after surgical PVR. Importantly, both rise before an increase in creatinine or a decrease in eGFR is present. Monitoring both biomarkers may allow for earlier detection and subsequent interventions to prevent AKI at time of surgery for CHD.


Subject(s)
Acute Kidney Injury/diagnosis , Acute-Phase Proteins/urine , Creatinine/blood , Heart Valve Prosthesis Implantation/adverse effects , Interleukin-18/urine , Lipocalins/urine , Proto-Oncogene Proteins/urine , Pulmonary Valve/surgery , Acute Kidney Injury/blood , Acute Kidney Injury/etiology , Acute Kidney Injury/physiopathology , Acute Kidney Injury/urine , Adolescent , Adult , Biomarkers/blood , Biomarkers/urine , Child , Child, Preschool , Early Diagnosis , Female , Glomerular Filtration Rate , Humans , Lipocalin-2 , Male , Middle Aged , Predictive Value of Tests , Prospective Studies , Time Factors , Treatment Outcome , Up-Regulation , Young Adult
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