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Bull Exp Biol Med ; 167(5): 637-640, 2019 Sep.
Article in English | MEDLINE | ID: mdl-31625065

ABSTRACT

Pharmacokinetics and relative bioavailability of antidepressant GSB-106 (hexamethylendiamide bis-(N-monosuccinyl-L-seryl-L-lysine) were determined in rabbits after single oral administration of the pharmaceutical substance and tablet mass. GSB-106 concentrations in the blood plasma were determined by HPLC-mass spectrometry. Relative bioavailability of GSB-106 tablet form was 160.79±24.33%.


Subject(s)
Antidepressive Agents/pharmacokinetics , Dipeptides/pharmacokinetics , Administration, Oral , Animals , Antidepressive Agents/blood , Area Under Curve , Biological Availability , Dipeptides/blood , Drug Evaluation, Preclinical , Male , Rabbits , Tablets
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