1.
Org Lett
; 13(23): 6320-3, 2011 Dec 02.
Article
in English
| MEDLINE
| ID: mdl-22070096
ABSTRACT
An intramolecular cyclization cascade reaction has been developed utilizing a high valent palladium intermediate that generates a carbon-carbon and carbon-oxygen bond in a single transformation. This method provides rapid access to highly functionalized tricyclic scaffolds, including spirocyclic cyclohexadienones. Good yields and mild conditions are reported with high tolerance toward oxygen and water.