[The protective action of tocopherol acetate in simultaneous administration with nitrobenzene and its chloro derivatives]. / Zashchitnoe deistvie tokoferola atsetata pri odnovremennom vvedenii s nitrobenzolom i ego khlorproizvodnymi.

In experiments in albino rats, effects were studied of nitrobenzene and its chloro derivatives in intragastric administration with tocoferolum acetatum. Changes in the process of lipid peroxidation in blood serum, liver, and spleen which were characteristic of xenobiotics themselves have been shown to be less pronounced in this setting. Tocoferolum acetatum being administered at the same time is actively drawn into the metabolism. Normalization of the antioxidant activity of the tissues under investigation was to be observed, with lipid peroxidation and the antioxidant system being in equilibrium. Tocoferolum acetatum administered with xenobiotics has been shown to have a protective action. Tocoferolum acetatum is recommended to be included into diets for workers engaged in chemical industry on a prophylactic basis.

[The action of nitrobenzene and its chlorine derivatives on the indices of antioxidative homeostasis in rat tissues]. / Deistvie nitrobenzola i ego khlor-proizvodnykh na nekotorye pokazateli antiokislitel'nogo gomeostaza v tkaniakh krys.

The authors studied the rate of lipid peroxidation, antioxidative activity and content of vitamin E in the liver and spleen of rats given nitrobenzene, o-nitrochlorbenzene and p-nitrochlorbenezene. The xenobiotics increased LPO, antioxidative activity (AOA), splenic levels of vitamin E. The subchronic influence of the substances led to stabilization of LPO, changes in the activation of the body's adaptation. The AOA and vitamin E play an important role in the regulation of antioxidative homeostasis.