[T-and B-cell immune response of lymph nodes and immunosuppression correlating with metastatic spread of stomach cancer].

A correlation was established in 708 stomach cancer patients between number of involved lymph nodes, on the one hand, and T- and B-cell immune response and morphological tumor pattern, on the other. That in turn significantly correlated with T-cell immune response and tumor localization. However, B-cell immune response and tumor size showed an inverse and less pronounced correlation with number of involved lymph nodes. Immunosuppression and metastatic spread are inter-connected; both quickly develop in succession in a node nearest to tumor and then continue invade. Immunosuppression is induced by tumor cytokines and innate regulatory T-cells which can either suppress or stimulate immune response, irrespective of tumor size.

[Multivariate analysis of significance of prognostic factors of immunological response and stomach tumor growth].

Significance of prognostic factors of immunological response, tumor growth and age was investigated in 708 patients with stomach cancer. Such factors as T-cell immunological response, functional status of lymph nodes and localization on either the greater or lesser curvature of the stomach were identified as the most significant while T-cell immunological response, tumor size and number of involved lymph nodes appeared less significant but more harmful as far as survival was concerned. No significant correlation between pattern of growth, depth of invasion, age and local immunological response, on the one hand, and survival, on the other, was established.

[Correlation of involved lymph nodes in stomach cancer with immunologic characteristics of the host and of the tumor]. / Izucheniie zavisimosti chisla limfaticheskikh uzlov s metastazami raka zheludka ot faktorov, kharakterizuiushchikh immunnuiu sistemy i opukhol'.

Correlations between certain factors and regional lymph nodes involvement with disseminated gastric cancer were investigated in 708 patients after stomach resection with lymph node dissection, without chemotherapy. Immune response of such nodes, their function and tumor localization in the stomach appeared to influence metastatic involvement most.

[Follicular hyperplasia of the regional lymph nodes in stomach cancer and its prognostic significance]. / Follikuliarnaia giperplaziia regionarnykh limfaticheskikh uzlov pri rake zheludka i ee prognosticheskoe znachenie.

Degree of follicular hyperplasia of regional lymph nodes (LFH) in patients with gastric tumors (T1-4N0M0) was evaluated versus 5-year survival, age, tumor size, depth of invasion and histologic pattern. Stage II-III LFH was found to have a favorable prognosis. Tumor size proved a factor influencing the degree. No apparent relationship between age, depth of invasion and degree of tumor cell differentiation, on the one hand, and LFH stage, on the other, was established.

[Prognostic significance of sinus histocytosis of the regional lymph nodes in stomach cancer]. / Prognosticheskoe znachenie sinus-gistiotsitoza regionarnykh limfaticheskikh uzlov pri rake zheludka.

A comparative study was made on different morphological pictures of the sinuses of the regional lymph nodes in gastric cancer patients with T1--4N0M0 with a 5-year survival, also the influence of age, depth of invasion, size and histological structure of the tumor on sinus histiocytosis was studied. Marked sinus histiocytosis, contrary to sinus fibrosis, was found to be a favourable prognostic sign. Sinus histiocytosis is influenced in a somewhat directly proportional way by the tumor size and histological differentiation. The given material rendered impossible to reveal any effect of age and depth of tumor invasion on sinus histiocytosis.