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Chem Biodivers ; 14(10)2017 Oct.
Article in English | MEDLINE | ID: mdl-28665538

ABSTRACT

Two new compounds, fuscaxanthones J (1) and K (2), together with eight known xanthones (3 - 10) were isolated from an ethyl acetate extract of the roots of Garcinia fusca. Their structures were determined using spectroscopic methods, mainly 1D- and 2D-NMR. α-Glucosidase inhibitory activity of the isolated compounds was evaluated and fuscaxanthone J (1) showed the most significant effect with an IC50 value of 8.3 ± 1.8 µm (compared with acarbose, IC50 = 214.5 ± 2.3 µm).


Subject(s)
Garcinia/chemistry , Glycoside Hydrolase Inhibitors/pharmacology , Plant Roots/chemistry , Xanthones/pharmacology , Dose-Response Relationship, Drug , Glycoside Hydrolase Inhibitors/chemistry , Glycoside Hydrolase Inhibitors/isolation & purification , Humans , Molecular Structure , Structure-Activity Relationship , Xanthones/chemistry , Xanthones/isolation & purification , alpha-Glucosidases/metabolism
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