ABSTRACT
The content of the free fatty acids, ketone bodies, total glycogen, glucose, adrenaline and noradrenaline and morpho-histochemical picture of the tissues of neuro-endocrinal system (hypophysis and adrenal) in the brain, heart, liver, skeletal muscles and blood of the white non-linear rats, were studied 2-3 min adaptation to complex atmosphere changes: gradual increase of the CO2, decrease of the O2, and cooling (in the condition of deep hypothermia the rectal temperature was--RT--19.1 +/- 0.1 degrees C). The same parameters were studied in 48 hrs after the same training (at normothermia) and in 2-3 min. after the same repeated training in 48 hrs after the first one, at RT--20.2 +/- 0.1 degrees C. The fluctuating character of the metabolism and of the regulating systems was shown.
Subject(s)
Carbohydrate Metabolism , Hypercapnia/metabolism , Hypothermia, Induced , Hypoxia/metabolism , Lipid Metabolism , Acetoacetates/metabolism , Acetylcholinesterase/metabolism , Adrenocorticotropic Hormone/metabolism , Animals , Brain/metabolism , Epinephrine/metabolism , Fatty Acids, Nonesterified/blood , Glucose/metabolism , Glycogen/metabolism , Hypercapnia/complications , Hypothalamo-Hypophyseal System/metabolism , Hypoxia/complications , Liver/metabolism , Male , Monoamine Oxidase/metabolism , Muscles/metabolism , Myocardium/metabolism , Norepinephrine/metabolism , RatsABSTRACT
The cooling of rats under conditions of hypercapnia and hypoxia during the first 15 minutes increases the contents of free fatty acids, acetoacetate and beta-oxybutyrate in the tissues of the brain, myocardium, liver, skeletal muscles and blood and decreases them by the end of the effect (120 min later) down to the initial values, in the liver and skeletal muscles tissues the content of the mentioned intermediates falls lower the initial values. In the carbohydrate metabolism the amount of phosphoenolpyruvate 15 and 120 min after the action beginning and the amount of malate in the myocardium and brain at the end of the experiment increase to a different extent; the content of lactate rises only in the brain 30 and 120 min after the beginning of cooling. In the rat venous blood the value of pCO2 increases up to 71.8+/-6.0 mm Hg, the total content of CO2 rises, the values of the standard bicarbonates decrease and the pH value drops sharply down to 6.98+/-0.03. It is suggested that one of the main reasons of such changes in metabolism is development of hypercapnia state and acidosis and the resulted increase in intensity of the carboxylation processes in the tissues.
