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Eksp Klin Farmakol ; 63(5): 56-8, 2000.
Article in Russian | MEDLINE | ID: mdl-11109530

ABSTRACT

Ammonia succinate potentiates the main pharmacological properties and reduces the toxic effects (ulcerogenic action and general toxicity) of acetylsalicylic acid. The new preparation astam, representing a combination of acetylsalicylic acid with ammonia succinate in a 2:1 ratio, is proposed. Astam exhibits antiexudative, capillary-reinforcing, antiproliferative, pain-relieving, antipyretic, antiaggregant, and antioxidant properties. In addition, the drug inhibits the development of structural-metabolic disorders in the case of chronic immune inflammation of joints and various internal organs.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Aspirin/pharmacology , Succinic Acid/pharmacology , Animals , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/toxicity , Antioxidants/pharmacology , Antioxidants/therapeutic use , Antioxidants/toxicity , Arthritis, Experimental/drug therapy , Arthritis, Experimental/metabolism , Aspirin/therapeutic use , Aspirin/toxicity , Dose-Response Relationship, Drug , Drug Combinations , Female , Lethal Dose 50 , Male , Mice , Peptic Ulcer/chemically induced , Platelet Aggregation Inhibitors/pharmacology , Platelet Aggregation Inhibitors/therapeutic use , Platelet Aggregation Inhibitors/toxicity , Rats , Succinic Acid/therapeutic use , Succinic Acid/toxicity , Toxicity Tests, Acute
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