[The prevalence, structure and clinical problems of multiple sclerosis in the Transcarpathian area based on epidemiological study data]. / Poshyrennia, struktura i deiaki pytannia kliniky mnozhynnoho sklerozu v Zakarpatti, za danymy epidemiolohichnoho doslidzhennia.

As many as 230 patients with disseminated sclerosis were examined in the Transcarpathian region. Sick male- and female populations were found out to be almost similar. There were more sick persons in the medium-range areas of the Carpathian Mountains, with a mean age being 35 +/- 5 years. It has been established that intake of spirulina makes for lengthening of remission in those patients with disseminated sclerosis.

[The incidence of the occurrence of stroke in the Carpathian region]. / Chastota vynyknennia mozkovoho insul'tu v Karpats'komu rehioni.

Based on the investigations conducted the contributors to this article arrived at a conclusion to the effect that those residing in lowlands of the Transcarpathian region are exposed to a greater number of factors causing acute cerebral circulatory disturbances than in highlands. This might be one of the reasons for the incidence of stroke to higher in low-lying lands that it is in mountainous areas. Factors due to which acute cerebral disturbances tend to develop need to be eliminated.

[The characteristics of the limbic-diencephalic disorders in patients with early forms of cerebral circulatory disturbances]. / Kharakteristika limbiko-diéntsefal'nykh rasstroistv u bol'nykh s rannimi formami narushenii mozgovogo krovoobrashcheniia.

The limbic and diencephalic disorders observed in patients with prestroke forms of cerebrovascular disturbances depend on clinical forms of cerebral circulation. Timely therapy is conducive to a more favourable course of cerebrovascular disturbances.

[Clinico-epidemiological characteristics of transient cerebral ischemia in the region of the Ukrainian Carpathian Mountains]. / Kliniko-épidemiologicheskie osobennosti prekhodiashchikh narushenii mozgovogo krovoobrashcheniia, registriruemykh v regione Ukrainskikh Karpat.

Altogether 225 patients with transitory derangements of cerebral circulation (TDCC) underwent clinico-laboratory examinations. Arterial hypertension and cerebral atherosclerosis turned out to be among most frequently occurring factors of TDCC. The provoking factors included psychoemotional stress and drops of barometric pressure. The course and outcome of TDCC were greatly affected by an increase in blood concentration of catecholamines and thyroid hormones. The high concentration of triiodothyronine in the blood contributed to the development of cerebral stroke.

[Familial predisposition to stroke in hypertension]. / Semeinaia predraspolozhennost' k mozgovomu insul'tu pri gipertonicheskoi bolezni.

Upon examination of 838 hypertensive subjects who had brain insult two groups of patients were distinguished: those whose parents suffered from hypertension and those without familial history of hypertension. It is found that when hypertension is inherited from mother, brain stroke occurs more frequently and in sons rather than in daughters.

[Neurologic syndromes in calcinosis of the vertebral artery]. / Nevrologicheskie sindromy pri obyzvestvlenii pozvonochnykh arterii.

Twenty-five patients with calcification of both vertebral arteries were examined. The following neurological syndromes associated with this pathology were revealed: paroxysmal and permanent vegetovascular dystonias, asthenoneurotic, convulsive, cochleovestibular and spinal myelopathy associated with lateral amyotrophic sclerosis.

[Variants of the clinical course of cerebrovascular diseases in various biogeochemical regions of the Ukrainian Carpathian Mountains]. / Varianty klinicheskogo techeniia tserebrovaskuliarnykh zabolevanii v nekotorykh biogeokhimicheskikh regionakh Ukrainskikh Karpat.

A total of 417 patients with cerebral circulatory disorders were examined in two biogeochemical regions of the UkrainianCarpathian Mountains. The first one is a region with iodine insufficiency; the second one is a region where the people use table salt in excess. It has been established that iodine insufficiency and excessive iodine concentration in the body of man are risk factors of the development of cerebrovascular disease. Besides, in persons with abnormal iodine metabolism, cerebrovascular diseases run a graver course than in those with normal content in the body of these trace elements.

[Neurologic manifestations of West Nile fever in the Transcarpathian region]. / Nevrologicheskie proiavleniia likhoradki Zapadnogo Nila v Zakarpat'e.

The authors describe the neurologic signs of West Nile fever observed in Transcarpathian region. Several syndromes were singled out: polyneuralgic, encephalitic, poliomyelitic, meningeal, encephalopolyradiculoneuritic. The course of the disease was benign.

[Epidemiology of stroke in the Ukrainian and Slovak Carpathian Mountains]. / K epidemiologii mozgovogo insul'ta v zonakh Ukrainskikh i Slovatskikh Karpat.

Different aspects of epidemiology of stroke were studied in residents of 2 adjacent geographic zones: USSR and Eastern Slovak Carpathian. A total of 385 cerebral stroke patients were studied in the USSR and 345 in Eastern Slovakia. Risk factors were determined. Cerebral serial angiography revealed that carotid and subclavian arteries pathology are major causes of stroke.

[Neuroendocrine syndromes in cerebrovascular pathology]. / Neiroéndokrinnye sindromy pri tserebrovaskuliarnoi patologii.

Study of hypothalamo-hypophyseo-adrenal, hypothalamo-hypophyseo-thyroid, and hypothalamo-hypophyseo-gonadotropic functions in 156 patients with various types of cerebral circulation disorders has permitted identification of 8 neuroendocrine syndromes in the patients with cerebrovascular pathology. The course and outcomes of these disorders in male and female patients with sexual gland dysfunctions are described. The authors believe that dysfunction of any component of the endocrine system may promote cardiovascular decompensation.

[Several possible pathogenetic mechanisms of cerebral circulatory disorders]. / O nekotorykh vozmozhnykh patogeneticheskikh mekhanizmakh narushenii mozgovogo krovoobrashcheniia.

The author examined the function of the hypothalamic-pituitary-thyroid system (HPTS) in 618 patients with various forms of cerebral circulation disorders and also carried out experiments on 50 rabbits. The results of the clinical-laboratory and experimental studies elicited the role of the HPTS in the pathogenesis of cerebral circulation disorders. HPTS dysfunction was shown to impair the thyroid homeostasis which led to a reduction in the cerebral redox processes, imbalance between the coagulation and anticoagulation systems, and changes in the composition of blood trace elements. All these changes contribute to the development of cerebral circulation disorders.

[Clinico-epidemiologic characteristics of cerebral circulatory disorders recorded in the Ukrainian Carpathian zone]. / Kliniko-épidemiologicheskaia kharakteristika narushenii mozgovogo krovoobrashcheniia, registriruemykh v zone Ukrainskikh Karpat.

A total of 845 patients with various forms of cerebral circulation impairments (CCI) were examined for the clinical picture and epidemiology of this pathology. High risk factors of acute impairments of the cerebral circulation have been identified. The effect of the meteorologic factors on the incidence and course of cerebral strokes has been established. It is concluded that salt hypertension is less frequently associated with acute impairments of the cerebral circulation as compared to other forms of essential hypertension.

[Participation of the thyroid gland in the mechanism of development of cerebral circulatory disorders (clinico-experimental study)]. / Uchastie shchitovidnoi zhelezy v mekhanizme vozniknoveniia rasstroistv mozgovogo krovoobrashcheniia (kliniko-éksperimental'nye issledovaniia).

Experiments on 30 rabbits, as well as clinical studies on 180 patients with cerebral circulation disorders were carried out. It was found that in patients with hypertensive disease complication, thyroid hyperactivity was observed only in the age group of 35 to 45 years. It was also found that in the patients with hypertensive disease and the complications of the latter, repeated stresses intensified the neurosecretory functions of the hypophysis and the hypothalamus: this, in its turn, influenced the hormone-synthetizing function of the thyroid. The chronic hyperthyroid syndrome present in those patients led to an increased oxygen consumption by tissues, slowed down the electron transport along the respiratory chain, increased the content of iodine and protein, and intensified the effects of pressor agents, i. e. aggravated the symptoms of the hypertensive disease. All those factors play a definite role in the mechanism of the development of the cerebral circulation disorders in hypertensive patients.