ABSTRACT
In asymptomatic hepatitis C virus (HCV)-infected blood donors and persons from high risk groups (intravenous drug users and hemodialyzed patients) HCV serotypes 1, 2, 3, 4 and 6 have been detected. The most frequent was serotype 1. In the group of intravenous drug users (IDU) a coexistence of different serotypes was observed.
Subject(s)
Blood Donors , Hepacivirus/classification , Hepatitis C/virology , Renal Dialysis/adverse effects , Substance Abuse, Intravenous/virology , Hepacivirus/isolation & purification , Hepatitis C/blood , Hepatitis C/transmission , Humans , Risk Factors , Serotyping , Substance Abuse, Intravenous/bloodABSTRACT
Investigations included a group 80 asymptomatic drug addicts. They were examined immunoenzyme method aiming at detection infection by HIV, HBV, HCV and HDV. Cases of seropositive HIV results were confirmed by means WB. In 68 examined patients serological evidence of virus HBV was discovered. In 60 of them one also found out coexisting HIV serological markers, in 51 of HCV markers. HDV antibodies were disclosed in 7 cases. Infection with hepatotropic viruses were more frequent in group of HIV(+) drug addicts.
Subject(s)
Acquired Immunodeficiency Syndrome/diagnosis , Hepatitis B/diagnosis , Hepatitis C/diagnosis , Hepatitis D/diagnosis , Substance Abuse, Intravenous/complications , Acquired Immunodeficiency Syndrome/etiology , Acquired Immunodeficiency Syndrome/immunology , Acquired Immunodeficiency Syndrome/transmission , Adolescent , Adult , Biomarkers , Female , HIV Antibodies/analysis , HIV-1/immunology , Hepacivirus/immunology , Hepatitis Antibodies/analysis , Hepatitis B/etiology , Hepatitis B/immunology , Hepatitis B/transmission , Hepatitis B virus/immunology , Hepatitis C/etiology , Hepatitis C/immunology , Hepatitis C/transmission , Hepatitis D/etiology , Hepatitis D/immunology , Hepatitis D/transmission , Hepatitis Delta Virus/immunology , Humans , Male , PolandABSTRACT
The gammaglobulin-fibrinogen index (GgF) was determined in 30 healthy subjects and 160 patients with chronic hepatic diseases related to HB infection. The group included 60 cases of chronic active hepatitis, 60 with compensated cirrhosis, 28 with decompensated cirrhosis, and 12 with primary hepatic carcinoma. The GgF index was found to be useful for preliminary diagnosis of the hepatic neoplasm and for differentiation of similar clinical pictures of decompensated cirrhosis and primary hepatic carcinoma.